Biochemical and Biophysical Research Communications, Год журнала: 2022, Номер 602, С. 105 - 112
Опубликована: Март 3, 2022
Язык: Английский
Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2025, Номер 49(3), С. 102529 - 102529
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2023, Номер 10(16)
Опубликована: Апрель 10, 2023
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury and acute failure, while the detection, prognosis prediction, therapy for APAP-induced (AILI) remain improved. Here, it determined that temporal pattern circulating cell-free DNA (cfDNA) strongly associated with damage inflammation parameters in AILI. CfDNA comparable to alanine aminotransferase (ALT) predicting mortality outperformed ALT when combined The depletion cfDNA or neutrophils alleviates damage, addition adoptive transfer exacerbates damage. combination DNase I N-acetylcysteine attenuates AILI significantly. This study establishes mechanistic biomarker predict mice. scavenging reducing oxidative provides promising treatment
Язык: Английский
Процитировано
21
Aging Cell, Год журнала: 2024, Номер 23(3)
Опубликована: Янв. 5, 2024
Abstract Recent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale vitro. MPS therefore provide potential to better understand human diseases physiology. To date, numerous platforms have been developed for various tissues organs, including heart, liver, kidney, blood vessels, muscle, adipose tissue. However, only few studies explored using unravel effects aging physiology pathogenesis age‐related diseases. Age is one risk factors many diseases, enormous interest has devoted research. As such, model could predictive tool molecular cellular mechanisms underlying These models can be used evaluate preclinical drugs translate them into clinical settings. Here, we review application First, offer an overview molecular, cellular, physiological changes with age several or organs. Next, discuss previous current state studying conditions. Lastly, address limitations present future directions
Язык: Английский
Процитировано
8
Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)
Опубликована: Июль 15, 2024
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes significant role as pivotal hub gene. The regulatory functions of HMGB1 within the nucleus and extracellular milieu are interlinked. exerts crucial influence on key biological processes including cell survival, inflammatory regulation, immune response. can be released extracellularly from during these processes, where it pro-inflammation cytokine. interacts with multiple membrane receptors, primarily Toll-like receptors (TLRs) receptor for advanced glycation end products (RAGE), to stimulate cells trigger excessive or uncontrolled release leads heightened responses cellular demise, instigating exacerbating inflammation demise in different diseases. Therefore, thorough review significance drug-induced is highly important advancement pharmaceuticals, ensuring their effectiveness safety treating well immune-related In this review, we initially outline characteristics emphasizing relevance disease pathology. Then, comprehensively summarize prospect promising therapeutic target toxicity. Lastly, discuss major challenges propose potential avenues advancing development HMGB1-based therapeutics.
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160181 - 160181
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177313 - 177313
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Critical Reviews in Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 55
Опубликована: Фев. 21, 2025
Acetaminophen [paracetamol; N-acetyl-para-aminophenol (APAP)] is an antipyretic/analgesic commonly used in the treatment of fever and mild to moderate pain, headache, myalgia, dysmenorrhea. Recent literature has questioned safety acetaminophen use during pregnancy, with emphasis on whether exposure developing nervous system results behavioral changes consistent autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), and/or other cognitive deficits offspring. No previous review a fully detailed, quantitative weight-of-evidence (QWoE) approach critically examine preclinical data regards potential developmental neurotoxicity (DNT). Following regulatory guidance, QWoE framework using prespecified scoring criteria was developed approaches characterize adverse DNT outcomes considerations for biological relevance response (outcome score) strength methods study design (methods score). Considerations score included (1) experimental design, (2) details/reliability measurement(s), (3) transparency, (4) translational/methodological relevance. outcome response-related statistical significance, dose-response, relevance/reliability/magnitude, plausibility, (5) translational relevance, including consideration systemic toxicity/hepatotoxicity therapeutic non-systemically toxic doses durations use. Application this 34 vivo studies identified that assess resulted 188 entries documented across 11 endpoints: social behavior, stereotypic rigidity, attention/impulsivity, hyperactivity, anxiety-like sensorimotor function, spatial learning/memory, nonspatial neuroanatomy, neurotransmission. For each endpoint, mean were calculated total segregated by sex assist determining quality adversity. Informed all entries, analysis demonstrated showing no evidence male female rodents following at nonsystemically doses. Although some endpoints (behavioral neurotransmission) generally displayed more limited dataset relatively lower quality, similar conclusions drawn based indicating lack reliability reported effects. Overall, demonstrates effects structure function system, neuroanatomical, neurotransmission, endpoints.
Язык: Английский
Процитировано
1
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Май 7, 2025
Язык: Английский
Процитировано
1
Food and Chemical Toxicology, Год журнала: 2022, Номер 169, С. 113445 - 113445
Опубликована: Сен. 29, 2022
Язык: Английский
Процитировано
25
Biomaterials Science, Год журнала: 2023, Номер 11(7), С. 2348 - 2358
Опубликована: Янв. 1, 2023
As one of the leading cases acute liver failure triggered by excessive Acetaminophen (APAP), breakdown antioxidant system, inflammatory response, and inescapable apoptosis following overaccumulation reactive oxygen species (ROS) play crucial roles in mechanisms APAP-induced injury (AILI). Therefore, cutting off ROS overproduction at source is considered promising. Here, manganese Prussian blue nanozymes (MPBZs) with superior enzyme-like activity are prepared as an effective strategy for hepatocyte protection, which MPBZs accumulated show anti-oxidation properties scavenging superfluous ROS. Importantly, addition to alleviating oxidative stress, bioactive abundant variable valence states a natural enzymes mediated responses multi-biological signaling pathways vitro vivo, including Nrf2-Keap1, NF-κB, mitochondrial-induced pathways, enhancing tolerance imminent AILI. Taking nanomedicine, hepatology, catalytic chemistry into consideration, revealed performance AILI prevention suggests that MPBZ-based nano-detoxification therapy may offer alternative against
Язык: Английский
Процитировано
16