Biomaterials, Год журнала: 2025, Номер 321, С. 123331 - 123331
Опубликована: Апрель 12, 2025
Язык: Английский
Tropical Medicine and Infectious Disease, Год журнала: 2023, Номер 8(11), С. 494 - 494
Опубликована: Ноя. 6, 2023
Hydatid cysts have been widely recognized for decades as a common medical problem that affects millions of people. A revolution in treatment may be on the prospect nanotechnology enhancing chemotherapy against hydatid cysts. An overview nanotechnology’s impact chemotherapeutics is presented current review. It discusses some challenges well opportunities. The application to enhance what this review will explore. Nanotechnology critical component delivering therapeutic agents with greater precision and efficiency targeting better efficacy, minimizing interference surrounding tissue. However, there are biodistribution challenges, toxicity, resistance problems associated nanotherapeutics. Additionally, nanobiosensors being investigated enable early diagnosis nanobiosensor can detect by catching them early, non-invasively, rapidly, accurately. sensitivity specificity diagnostic tests enhanced because they take advantage unique properties nanomaterials. By providing more precise customized options cysts, improve strategies diagnosing disease. In conclusion, treat potentially effective but presents many obstacles. Furthermore, integrated into techniques, helping diagnose patients earlier
Язык: Английский
Процитировано
21
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 198, С. 114858 - 114858
Опубликована: Май 12, 2023
Язык: Английский
Процитировано
20
Pathogens and Disease, Год журнала: 2024, Номер 82
Опубликована: Янв. 1, 2024
Abstract Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection globally. Antibiotic treatment highly effective, but often asymptomatic resulting in individuals going undetected and untreated. This untreated can ascend to upper female genital tract cause pelvic inflammatory disease, tubal factor infertility, ectopic pregnancy. screening programs have failed control this epidemic demonstrate need for an efficacious vaccine prevent transmission disease. Animal models human epidemiological data reveal that natural immunity provide partial or short-lived sterilizing immunity. These further importance of eliciting interferon gamma (IFNγ)-producing cluster differentiation 4 (CD4) T cells (Th1 Th1/17 cells) likely synergize with antibody-mediated opsonophagocytosis optimal protection. studies guided preclinical rational design decades first Phase 1 clinical trials recently been completed. Recent advances led improvements platforms clinically safe adjuvants help a path forward. review describes models, correlates immunity, antigen adjuvant selection, future testing development.
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10880 - 10880
Опубликована: Июнь 29, 2023
The development of efficient mucosal vaccines is strongly dependent on the use appropriate vectors. Various biological systems or synthetic nanoparticles have been proposed to display and deliver antigens surfaces. Bacillus spore, a metabolically quiescent extremely resistant cell, has also as vaccine delivery system shown able conjugate advantages live systems. Several displayed spore by either recombinant non-recombinant approaches, antigen-specific immune responses observed in animals immunized oral nasal route. Here we review bacterial vehicle focusing drawbacks using vs. approach surface. An overview induced antigen-displaying spores so far tested presented discussed.
Язык: Английский
Процитировано
15
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5037 - 5056
Опубликована: Май 24, 2024
The oral and nasal cavities serve as critical gateways for infectious pathogens, with microorganisms primarily gaining entry through these routes. Our first line of defense against invaders is the mucosal membrane, a protective barrier that shields body's internal systems from infection while also contributing to vital functions like air nutrient intake. One key features this its ability protect physiological system pathogens. Additionally, tolerance plays crucial role in maintaining homeostasis by regulating pH water balance within body. Recognizing importance barrier, researchers have developed various formulations enhance immune response. Mucosal vaccines, example, deliver antigens directly tissues, triggering local stimulation ultimately inducing systemic immunity. Studies shown lipid-based such liposomes virosomes can effectively elicit both responses. Furthermore, mucoadhesive polymeric particles, their prolonged delivery target sites, demonstrated an enhanced This Review delves into material selection approaches optimizing
Язык: Английский
Процитировано
5
Journal of Dental Research, Год журнала: 2023, Номер 102(7), С. 709 - 718
Опубликована: Май 6, 2023
Vaccine technology has evolved continuously since its beginning, and mucosal vaccination, including intranasal, sublingual, oral administrations, recently gained great scientific interest. The mucosa represents a promising minimally invasive route for antigen delivery, mainly at sublingual buccal sites, it is easily accessible, immunologically rich, able to promote an effective systemic local immune response. aim of this review provide updated overview on the technologies with emphasis mucoadhesive biomaterial-based delivery systems. Polymeric-based nanoparticles, multilayer films wafers, liposomes, microneedles, thermoresponsive gels are most investigated strategies deliver antigens locally, showing properties, controlled release antigen, ability enhance immunological responses. These formulations have achieved adequate properties in terms vaccine stability, invasive, easy produce manage. To date, systems represent open field research. Future directions should focus role these induce sustained innate adaptive responses, by integrating recent advances mucoadhesion those related technology. Being painless, administer, highly stable, safe, effective, via may useful strategy fast mass especially during pandemic outbreaks.
Язык: Английский
Процитировано
12
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105022 - 105022
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
12
Nature Reviews Materials, Год журнала: 2023, Номер 9(1), С. 29 - 45
Опубликована: Дек. 18, 2023
Язык: Английский
Процитировано
12
Fish & Shellfish Immunology, Год журнала: 2023, Номер 145, С. 109326 - 109326
Опубликована: Дек. 21, 2023
Язык: Английский
Процитировано
12
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
In the dynamic realm of translational nanorobotics, endeavor to develop nanorobots carrying therapeutics in rational vivo applications necessitates a profound understanding biological landscape human body and its complexity. Within this landscape, membranes stand as critical barriers successful delivery therapeutic cargo target site. Their crossing is not only challenge for nanorobotics but also pivotal criterion clinical success therapeutic-carrying nanorobots. Nevertheless, despite their urgency, strategies membrane remain relatively underrepresented scientific literature, signaling an opportunity further research innovation. This review focuses on with various propulsion mechanisms from chemical physical hybrid mechanisms, it identifies describes four essential that represent needed be crossed journey applications. First entry point into blood stream, which skin or mucosa intravenous injection; next exit bloodstream across endothelium site; cell through plasma and, finally, escape lysosome, otherwise destroys cargo. The discusses design challenges inherent translating nanorobot technologies real-world provides overview documented crossings. aim underscore need interdisciplinary collaborations between chemists, materials scientists biologists vital domain has potential revolutionize field precision medicine.
Язык: Английский
Процитировано
0