Ribonucleic
acid
(RNA)
plays
a
pivotal
role
in
gene
regulation
and
protein
biosynthesis.
Interfering
the
physiological
function
of
key
RNAs
to
induce
cell
apoptosis
holds
great
promise
for
cancer
treatment.
Many
RNA-targeted
anti-cancer
strategies
have
emerged
continuously.
Among
them,
RNA
interference
(RNAi)
has
been
recognized
as
promising
therapeutic
modality
various
disease
treatments.
Nevertheless,
primary
obstacle
siRNA
delivery-escaping
endosome
crossing
plasma
membrane
severely
impedes
its
potential.
Thus
far,
variety
nanosystems
well
carrier-free
bioconjugation
delivery
developed
employed
enhance
drug
anti-tumor
efficiency.
Besides,
use
small
molecules
target
specific
structures
disrupt
their
function,
along
with
covalent
modification
RNA,
also
drawn
tremendous
attention
recently
owing
high
efficacy.
In
this
review,
we
will
provide
an
overview
recent
progress
therapy
including
strategies,
RNA-targeting
molecules,
newly
modification.
Finally,
challenges
future
perspectives
faced
research
field
be
discussed.
Journal of Biomedical Science,
Год журнала:
2024,
Номер
31(1)
Опубликована: Сен. 10, 2024
Abstract
Realizing
the
immense
clinical
potential
of
mRNA-based
drugs
will
require
continued
development
methods
to
safely
deliver
bioactive
agents
with
high
efficiency
and
without
triggering
side
effects.
In
this
regard,
lipid
nanoparticles
have
been
successfully
utilized
improve
mRNA
delivery
protect
cargo
from
extracellular
degradation.
Encapsulation
in
was
an
essential
factor
successful
application
vaccines,
which
conclusively
demonstrated
technology's
yield
approved
medicines.
review,
we
begin
by
describing
current
advances
modifications,
design
novel
lipids
nanoparticle
components
for
drugs.
Then,
summarize
key
points
pertaining
preclinical
therapeutics.
Finally,
cover
topics
related
targeted
systems,
including
endosomal
escape
targeting
immune
cells,
tumors
organs
use
vaccines
new
treatment
modalities
human
diseases.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Дек. 21, 2022
Engineered
nanoparticles
have
enabled
the
development
of
novel
uses,
particularly
in
disease
management.
In
this
investigation,
we
synthesized
and
studied
three
distinct
nanomaterials:
solid
lipid
(SLNPs),
chitosan
(CSNPs),
carbon
nanotubes
(CNTs),
either
alone
or
loaded
with
two
antifungals,
nystatin,
fluconazole.
The
purpose
study
is
to
investigate
different
properties
produced
nanomaterials,
combination
antifungals.
Drug
release
studies
revealed
that
about
55%
from
SLNPs,
43%
CSNPs
97%
CNTs
nystatin
drug
were
released
at
longest
time
point
assessed
(12
h).
addition,
89%
84%
81%
fluconazole
This
research
will
expand
understanding
nanomaterials
as
a
viable
technique
for
management
fungal
diseases
harm
several
agricultural
crops.
Ribonucleic
acid
(RNA)
plays
a
pivotal
role
in
gene
regulation
and
protein
biosynthesis.
Interfering
the
physiological
function
of
key
RNAs
to
induce
cell
apoptosis
holds
great
promise
for
cancer
treatment.
Many
RNA-targeted
anti-cancer
strategies
have
emerged
continuously.
Among
them,
RNA
interference
(RNAi)
has
been
recognized
as
promising
therapeutic
modality
various
disease
treatments.
Nevertheless,
primary
obstacle
siRNA
delivery-escaping
endosome
crossing
plasma
membrane
severely
impedes
its
potential.
Thus
far,
variety
nanosystems
well
carrier-free
bioconjugation
delivery
developed
employed
enhance
drug
anti-tumor
efficiency.
Besides,
use
small
molecules
target
specific
structures
disrupt
their
function,
along
with
covalent
modification
RNA,
also
drawn
tremendous
attention
recently
owing
high
efficacy.
In
this
review,
we
will
provide
an
overview
recent
progress
therapy
including
strategies,
RNA-targeting
molecules,
newly
modification.
Finally,
challenges
future
perspectives
faced
research
field
be
discussed.
