Recent advances in the development of tumor microenvironment-activatable nanomotors for deep tumor penetration

Materials Today Bio, Год журнала: 2024, Номер 27, С. 101119 - 101119

Опубликована: Июнь 11, 2024

Cancer represents a significant threat to human health, with the use of traditional chemotherapy drugs being limited by their harsh side effects. Tumor-targeted nanocarriers have emerged as promising solution this problem, they can deliver directly tumor site, improving drug effectiveness and reducing adverse However, efficacy most nanomedicines is hindered poor penetration into solid tumors. Nanomotors, capable converting various forms energy mechanical for self-propelled movement, offer potential enhancing delivery deep regions. External force-driven nanomotors, such those powered magnetic fields or ultrasound, provide precise control but often necessitate bulky costly external equipment. Bio-driven propelled sperm, macrophages, bacteria, utilize biological molecules self-propulsion are well-suited physiological environment. constrained lifespan, inadequate speed, immune responses. To address these issues, nanomotors been engineered propel themselves forward catalyzing intrinsic "fuel" in microenvironment. This mechanism facilitates through barriers, allowing them reach regions targeted delivery. In regard, article provides review microenvironment-activatable (fueled hydrogen peroxide, urea, arginine), discusses prospects challenges clinical translation, aiming new insights safe, efficient, treatment cancer therapy.

Язык: Английский

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Recent advances in chemodynamic nanotherapeutics to overcome multidrug resistance in cancers

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117901 - 117901

Опубликована: Фев. 11, 2025

Язык: Английский

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siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Synthesis and Hydrolysis Mechanism of Calcium Sulfide for H2S Production from Gypsum Waste

Vacuum, Год журнала: 2025, Номер unknown, С. 114185 - 114185

Опубликована: Фев. 1, 2025

Язык: Английский

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Thiotaurine inhibits melanoma progression by enhancing Ca2+ overload-induced cellular apoptosis

Journal of Dermatological Science, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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