Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(6), С. 2296 - 2297
Опубликована: Июнь 1, 2023
Язык: Английский
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(7), С. 3169 - 3183
Опубликована: Март 7, 2024
Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle profitable gene therapy. Lipid nanoparticles (LNPs), considered prospective vehicle nucleic acid delivery, have demonstrated efficacy in human use during the COVID-19 pandemic. This study introduces novel biomaterial-based platform, M1-polarized macrophage-derived cellular nanovesicle-coated LNPs (M1-C-LNPs), specifically engineered combined gene-immunotherapy approach against solid tumor. The dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within and immune-modulating cytokines M1 nanovesicles (M1-NVs), effectively facilitating apoptosis cancer cells without impacting T NK cells, which activate intratumoral immune response promote granule-mediating killing tumor eradication. Enhanced retention was observed upon administration M1-C-LNPs, owing presence adhesion molecules on M1-NVs, thereby contributing superior growth inhibition. These findings represent promising strategy development targeted effective nanoparticle-based genetic-immunotherapy, with significant implications advancing biomaterial therapeutics.
Язык: Английский
Процитировано
5
Advanced Functional Materials, Год журнала: 2024, Номер 34(46)
Опубликована: Июль 1, 2024
Abstract The use of cellular nanovesicles (CNVs) is a groundbreaking innovation in biomedical applications. Both natural extracellular vesicles (EVs) and artificial cell membrane (AVs) have emerged as innovative CNVs, but they limitations therapeutic effects targeting abilities. Challenges such stability, immunogenicity, drug payload capacity hinder their widespread application. Genetic engineering has matured widely employed modification strategy, leading to the development genetically engineered (gEVs) (gAVs). This review meticulously examines diverse types inherent characteristics alongside various surface strategies for with specific focus on elucidating attributes detailing preparation methods relevant gEVs gAVs. Furthermore, this exploration delves into expansive landscape applications, developmental prospects, current challenges associated utilization With comprehensive approach, primary objective provide insights that not only illuminate nuanced intricacies these also pave way seamless integration clinical research eventual translation practical
Язык: Английский
Процитировано
5
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Март 8, 2023
The conventional therapeutic approaches to treat autoimmune diseases through suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory drugs, are not adequately practical. Moreover, these regimens associated with considerable complications. Designing tolerogenic strategies based on stem cells, their extracellular vesicles (EVs) seems open a promising path managing diseases’ vast burden. Mesenchymal stem/stromal cells (MSCs), dendritic regulatory T (Tregs) main cell types applied restore status; MSCs play more beneficial role due amenable properties extensive cross-talks different cells. With existing concerns about employment of new cell-free paradigms, EV-based therapies, gaining attention in this field. Additionally, EVs’ unique have made them be known smart immunomodulators considered potential substitute for therapy. This review provides an overview advantages disadvantages cell-based methods treating diseases. study also presents outlook future EVs implemented clinics patients.
Язык: Английский
Процитировано
11
Deleted Journal, Год журнала: 2023, Номер 2(1), С. 241 - 274
Опубликована: Июль 19, 2023
Wound regeneration is a typical physiological mechanism consisting of series molecular and cellular processes that take place after the commencement tissue lesion to reestablish barrier between body external surroundings. Chronic non-healing wounds, on other hand, require additional therapeutic qualities which could be obtained by using exosomes (Exo) nanoparticles (NPs) stimulate rapid superior healing results. Many scientists have worked understand mechanisms wound healing, there are several reviews subject. To best our understanding, nevertheless, has been little study utilization Exo NPs in healing. Our research aims bridge knowledge gap. This first previous studies wounds standard management methods. close gap current research, we extensively discuss state-of-the-art engineered BioM-based approaches, including exosome procedures nanoparticle-based BioMs for Furthermore, applications techniques described. then closes reviewing existing discussing multiple synthesized BioM infectious
Язык: Английский
Процитировано
9
Pharmaceutics, Год журнала: 2023, Номер 16(1), С. 22 - 22
Опубликована: Дек. 22, 2023
The medical community is constantly searching for new and innovative ways to treat cancer, cellular-membrane-derived artificial vesicles are emerging as a promising avenue cancer immunotherapy. These vesicles, which derived from mammal bacteria cell membranes, offer range of benefits, including compatibility with living organisms, minimal immune response, prolonged circulation. By modifying their surface, manipulating genes, combining them other substances, stimulating externally, even enclosing drugs within them, cellular have the potential be powerful tool in fighting cancer. ability merge diverse compositions functionalities localized area particularly exciting, it offers way combine different immunotherapy treatments maximum impact. This review contains information on various sources these discusses some recent developments using this technology. While there still obstacles overcome, possibilities treatment truly exciting.
Язык: Английский
Процитировано
7
Pathology - Research and Practice, Год журнала: 2024, Номер 257, С. 155288 - 155288
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 11, 2024
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, demonstrating unprecedented efficacy against advanced cancers. However, their clinical applications are significantly hampered by low overall response rates. Dual blockade of two immune checkpoints represents a promising strategy to enhance immunotherapeutic efficacy. In this study, we developed hybrid cell membrane nanovesicles adorned with PD-1 and SIRPα receptors for combination immunotherapy in melanoma. Our (PD-1/SIRPα NVs) demonstrated high specificity PD-L1 CD47 ligands, facilitating the phagocytosis melanoma cells macrophages. mouse model, PD-1/SIRPα NVs suppressed 77% tumor growth elicited robust antitumor immunotherapy. conclusion, our findings highlight potential as novel effective ICIs
Язык: Английский
Процитировано
2
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Дек. 19, 2023
Exosomes are natural extracellular vesicles that play a key role in inter- and intracellular communication. Currently they considered as promising therapeutic strategy for the treatment of various diseases. In osteoimmunology, exosomes can serve biomarkers bone homeostasis disorders and, at same time, agents with high stability biological environment, low immunogenicity good bioavailability. this review, we attempted to examine mediators intercellular communication, playing an essential interaction immune system tissue, based on analysis PubMed database up October 2023.
Язык: Английский
Процитировано
5
OpenNano, Год журнала: 2022, Номер 8, С. 100085 - 100085
Опубликована: Сен. 9, 2022
Tumor development is influenced by cell interactions within the tumor microenvironment (TME). Extracellular vesicles (EVs) released from cells mediate critical signals that communicate with their TME to modulate progression. These EVs can result in resistance chemotherapy or immunotherapy during cancer treatment. Studies related tumor-derived EV biogenesis and components have led new strategies enhance sensitivity standard treatments blocking neutralizing formation. Furthermore, engineered expressing specific ligands receptors been investigated for targeted delivery of therapeutic agents, improving treatment efficacy, mitigating adverse effects. In addition, modified function as vaccines promote immunity.
Язык: Английский
Процитировано
8
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116591 - 116591
Опубликована: Апрель 16, 2024
The characteristics of fibrosis include the abnormal accumulation extracellular matrix proteins and tissue repair caused by injury, infection, inflammation, leading to a significant increase in organ failure mortality. Effective precise treatments are urgently needed halt reverse progression fibrotic diseases. Exosomes tiny vesicles derived from endosomes, spanning 40 160 nanometers diameter, which expelled into environment various cell types. They play crucial role facilitating cell-to-cell communication transporting variety cargoes, including proteins, RNA, DNA. Epithelial cells serve as primary barrier against diverse external stimuli that precipitate Numerous research suggests exosomes epithelial have impact on several An in-depth comprehension cellular molecular mechanisms cell-derived holds promise for advancing exploration novel diagnostic biomarkers clinical drug targets. In this review, we expand upon pathogenic epithelium-derived highlight their process inducing inflammation activating fibroblasts. addition, particularly interested bioactive molecules carried epithelial-derived potential value diagnosis treatment delineate utility an emerging therapeutic modality, highlighting application addressing medical conditions.
Язык: Английский
Процитировано
1