Neurochemical Research, Год журнала: 2025, Номер 50(2)
Опубликована: Март 7, 2025
Язык: Английский
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Янв. 28, 2025
Introduction The global health challenge of ulcerative colitis (UC) has been classified by the WHO as a modern refractory disease, commonly referred to green cancer, with limited treatment options still available, highlighting urgent need for development new therapeutic strategies. Recent pharmacological research shown that traditional Chinese medicine saussurea costus (SC) possesses beneficial antibacterial and anti-inflammatory properties. Nevertheless, its underlying mechanism remains elusive. Methods Firstly, we identified main active components SC through UHPLC-QTOF-MS analysis. Subsequently, UC mice were induced using DSS administered different doses evaluate efficacy. Additionally, impact on repair intestinal mucosal barrier was evaluated immunofluorescence western blot. Furthermore, 16s rRNA gene sequencing conducted elucidate contribution gut microbiota pathogenesis. Results primary include Proline, Phenylalanine, Isoleucine, Lucidenic acid M, Pyroglutamic acid. efficacy concurrently assessed, revealing potential ameliorate histological injury in mice. found decrease levels TNF-α, IL-1β, IL-8, IL-18 while promoting expression IL-10 IL-22. Similarly, also ZO-1 Occludin reversed In addition, analysis 16S indicated reduced harmful bacterial populations, such Proteobacteria , simultaneously enhancing bacteria like Lactobacillus thereby contributing improvement pathology. Conclusion This study highlights managing ability attenuate inflammatory responses, restore functionality, modulate composition, which findings offer insights into strategies advancing treatment.
Язык: Английский
Процитировано
1
Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Abstract Neuroinflammation is crucial for the pathogenesis of major depression. Preclinical studies have shown potential anti-inflammatory agents, specifically costunolide (COS), correlate with antidepressant effects. In this study, we investigated molecular mechanisms underlying actions COS. Chronic restraint stress (CRS) was induced in male mice. The mice were treated either intra-DG injection COS (5 μM, 1 μL per side) or (20 mg/kg, i.p.) week. We showed that administration through both routes significantly ameliorated depressive-like behavior CRS-exposed Furthermore, improved chronic stress-induced adult hippocampal neurogenesis deficits attenuating microglia-derived neuroinflammation. demonstrated μM) exerted anti-neuroinflammatory effects LPS-treated BV2 cells via inhibiting microglial Akt/mTOR/NF-κB pathway; inactivation mTOR/NF-κB/IL-1β pathway required pro-neurogenic action Our results reveal mechanism normalizing neuroinflammation to improve deficits, supporting agents as a therapeutic strategy
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2024, Номер 130, С. 155581 - 155581
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
8
Current Medicinal Chemistry, Год журнала: 2024, Номер 31(15), С. 2021 - 2051
Опубликована: Фев. 4, 2024
Abstract: Inflammasomes are multimeric protein complexes that can detect various physiological stimuli and danger signals. As a result, they perform crucial function in the innate immune response. The NLRP3 inflammasome, as vital constituent of inflammasome family, is significant defending against pathogen invasion preserving cellhomeostasis. dysregulation connected to pathological conditions, including inflammatory diseases, cancer, cardiovascular neurodegenerative diseases. This profile makes an applicable target for treating related therefore, there rising inhibitors disclosed therapy. Herein, we summarized updated advances structure, function, inflammasome. Moreover, aimed provide overview existing products future directions drug research development.
Язык: Английский
Процитировано
5
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(9), С. 7516 - 7538
Опубликована: Апрель 30, 2024
The NLRP3 inflammasome has been recognized as a promising therapeutic target in drug discovery for inflammatory diseases. Our initial research identified natural sesquiterpene isoalantolactone (IAL) the active scaffold targeting inflammasome. To improve its activity and metabolic stability, total of 64 IAL derivatives were designed synthesized. Among them, compound
Язык: Английский
Процитировано
5
Phytochemistry, Год журнала: 2024, Номер 221, С. 114041 - 114041
Опубликована: Март 3, 2024
Язык: Английский
Процитировано
4
Inflammopharmacology, Год журнала: 2024, Номер 32(3), С. 2007 - 2022
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
Heart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded pivotal factor in onset progression HF. Therefore, inhibiting activation NLRP3 may represent promising therapeutic approach for preventing treating The active ingredients serve foundation effects traditional Chinese medicine (TCM). Recent research revealed advantages TCM enhancing cardiac structure function study aimed explore impact on HF, review current advancements utilizing inhibit This provides novel perspective future development precise intervention strategies targeting prevent treat
Язык: Английский
Процитировано
0
Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117262 - 117262
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(15), С. 2756 - 2778
Опубликована: Июль 30, 2024
Alzheimer's disease (AD) is the most prevalent cause of dementia and characterized by low levels acetyl butyrylcholine, increased oxidative stress, inflammation, accumulation metals, aggregations Aβ tau proteins. Current treatments for AD provide only symptomatic relief without impacting pathological hallmarks disease. In our ongoing efforts to develop naturally inspired novel multitarget molecules AD, through extensive medicinal chemistry efforts, we have developed 13a, harboring key functional groups not but also targeting able chelate iron, inhibiting NLRP3, Aβ1–42 aggregation in various models. 13a exhibited promising anticholinesterase activity against AChE (IC50 = 0.59 ± 0.19 μM) BChE 5.02 0.14 with excellent antioxidant properties DPPH assay 5.88 0.21 over ferulic acid (56.49 0.62 μM). The molecular docking dynamic simulations further corroborated enzyme inhibition studies confirmed stability these complexes. Importantly, PAMPA-BBB assay, turned out be a molecule that can efficiently cross blood–brain barrier. Notably, iron-chelating properties. Furthermore, effectively inhibited self- metal-induced aggregation. It worth mentioning demonstrated no symptom cytotoxicity up 30 μM concentration PC-12 cells. Additionally, NLRP3 inflammasome mitigated mitochondrial-induced reactive oxygen species mitochondrial membrane potential damage triggered LPS ATP HMC-3 could reduce cellular (ROS) Drosophila model AD. Finally, was found efficacious reversing memory impairment scopolamine-induced mouse vivo studies. ex assessments, notably modulates superoxide, catalase, malondialdehyde along BChE. These findings revealed holds promise as candidate development management.
Язык: Английский
Процитировано
3