AAPS PharmSciTech, Год журнала: 2024, Номер 26(1)
Опубликована: Дек. 5, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132579 - 132579
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
38
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
19
Aspects of Molecular Medicine, Год журнала: 2025, Номер 5, С. 100062 - 100062
Опубликована: Янв. 5, 2025
Процитировано
8
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 84, С. 104494 - 104494
Опубликована: Май 16, 2023
Язык: Английский
Процитировано
26
Advanced Functional Materials, Год журнала: 2024, Номер 34(30)
Опубликована: Март 21, 2024
Abstract The combination of chemotherapy and immunotherapy holds great potential in clinical treatment advanced cancers. Whereas, the therapeutic outcome chemotherapeutic immune regulator is suboptimal due to their poor tumor availability severe off‐target toxicity. Herein, self‐carrier nanoparticles (PSMT NPs) integrating a paclitaxel (PTX) prodrug indoleamine 2,3‐dioxygenase 1 (IDO) inhibitor (1‐methyl‐tryptophan, 1MT) for tumor‐specific chemo‐immunotherapy constructed. After internalization by cancer cells, PSMT NPs can respond endogenous redox stimulus, release PTX 1MT. released not only promote cell apoptosis via intervention mitosis but also initiate immunogenic death facilitate recruitment activation tumor‐infiltrating cytotoxic T lymphocytes. concomitant 1MT inhibit IDO activity exhaust regulatory thereby synergistically activating exhibit potentiated antitumor output toward triple‐negative breast negligible systemic This facile versatile nanoplatform provides promising strategy cooperatively activate immunity chemo‐immunotherapy.
Язык: Английский
Процитировано
12
Advanced Science, Год журнала: 2023, Номер 11(2)
Опубликована: Ноя. 12, 2023
Abstract Combined chemotherapy and targeted therapy holds immense potential in the management of advanced gastric cancer (GC). GC tissues exhibit an elevated expression level protein kinase B (AKT), which contributes to disease progression poor chemotherapeutic responsiveness. Inhibition AKT through inhibitor, capivasertib (CAP), enhance cytotoxicity paclitaxel (PTX) toward cells is demonstrated this study. A cathepsin B‐responsive polymeric nanoparticle prodrug system employed for co‐delivery PTX CAP, resulting a nano‐drug BPGP@CAP. The release CAP triggered environment with overexpressed upon lysosomal uptake synergistic therapeutic effect on killing confirmed by vitro vivo experiments. Mechanistic investigations suggested that may inhibit expression, leading suppression phosphoinositide 3‐kinase (PI3K)/AKT signaling pathway. Encouragingly, can synergize exert potent antitumor effects against after they are co‐delivered via drug delivery system, helped reduce their toxic side effects, provides effective strategy treating GC.
Язык: Английский
Процитировано
18
Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 168 - 181
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
7
Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 27
Опубликована: Янв. 9, 2025
Molecular Dynamics (MD) simulations are now widely utilized in pharmaceutical nanotechnology to gain deeper understanding of nanoscale processes imperative drug design. This review has also detailed how MD simulation can be employed the study drug-nanocarrier interactions, controlling release chemical compounds from delivery systems and increasing solubility bioavailability nanocarriers. Furthermore, contributes examining systems, measuring toxic effects, determining biocompatibility nanomedical systems. With incorporation artificial intelligence use hybrid gone a step ahead model other niches biology that make tremendous opening develop highly selective nanomedications. Nevertheless, with well-known issues such as computational constraints discrepancy between silico experiment results, remains work progress, considerable promise for replacing or supplementing existing approaches development precision medicine nanomedicine, continued progression healthcare hopeful.
Язык: Английский
Процитировано
1
Polymers, Год журнала: 2024, Номер 16(3), С. 405 - 405
Опубликована: Фев. 1, 2024
Liposomes show promise for anti-cancer drug delivery and tumor-targeted therapy. However, complex tumor microenvironments the performance limitations of traditional liposomes restrict clinical translation. Hyaluronic acid (HA)-modified nanoliposomes effectively target CD44-overexpressing cells. Combination therapy enhances treatment efficacy delays resistance. Here, we developed paclitaxel (PTX) co-modified with ginsenoside compound K (CK) HA using film dispersion. Compared to cholesterol (Ch), CK substantially improved encapsulation efficiency stability. In vitro release studies revealed pH-responsive behavior, slower at pH 7.4 versus faster 5. cytotoxicity assays demonstrated that replacing Ch in modified considerably decreased HCT-116 cell viability. Furthermore, flow cytometry fluorescence microscopy showed a higher cellular uptake PTX-CK-Lip-HA CD44-high cells, reflected lower half maximal inhibitory concentrations. Overall, CK/HA-modified represent an innovative, targeted system enhanced via pH-triggered CD44 binding.
Язык: Английский
Процитировано
5
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(10), С. 4632 - 4636
Опубликована: Авг. 17, 2024
Язык: Английский
Процитировано
3