Repurposing Brucine as a Chemopreventive Agent in Mammary Gland Carcinoma: Regulating Lactate Transport through MCT-4

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101902 - 101902

Опубликована: Янв. 10, 2025

Язык: Английский

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Metabolic programming of pancreatic and colon cancer

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 325 - 340

Опубликована: Янв. 1, 2025

Язык: Английский

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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 21, 2025

Gastric cancer remains a leading cause of cancer-related mortality worldwide, with advanced stages presenting significant challenges due to metastasis and drug resistance. Traditional Chinese Medicine (TCM) offers promising complementary approach characterized by holistic treatment principles minimal side effects. This review comprehensively explores the multifaceted mechanisms which TCM addresses gastric cancer. Specifically, we detail how inhibits aerobic glycolysis downregulating key glycolytic enzymes metabolic pathways, thereby reducing energy supply essential for cell proliferation. We examine suppresses angiogenesis targeting vascular endothelial growth factor (VEGF) cyclooxygenase-2 (COX-2) effectively starving tumors nutrients oxygen required metastasis. Furthermore, modulates immune microenvironment enhancing activity effector cells such as CD4 + CD8 T natural killer (NK) while immunosuppressive like regulatory (Tregs) myeloid-derived suppressor (MDSCs). These actions collectively contribute slowing tumor progression, inhibiting metastasis, body’s antitumor response. The insights presented underscore potential an integral component comprehensive strategies, highlighting avenues future research clinical application improve patient outcomes.

Язык: Английский

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Intranuclear TCA and mitochondrial overload: the nascent sprout of tumors metabolism

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217527 - 217527

Опубликована: Фев. 1, 2025

Язык: Английский

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Ldha Accelerates Primary Cisplatin Resistance in Lung Adenocarcinoma by Modulating Ambra1 Ubiquitination Via Moonlighting Functions

Опубликована: Янв. 1, 2025

Язык: Английский

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HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 10, 2025

Resistance to treatment is a critical factor contributing poor prognosis in gastric cancer patients. HSP90 has emerged as promising therapeutic target; however, its role regulating tumor metabolic pathways, particularly glycolysis, remains poorly understood, which limits clinical application. We identified proteins that directly interact with using immunoprecipitation (IP) followed by mass spectrometry. The relationship between and glycolysis was further investigated through transcriptomic analyses vitro experiments. Mechanistic insights were obtained spectrometry, co-immunoprecipitation (Co-IP) assays, drug sensitivity tests, bioinformatics analyses. Additionally, we developed scoring system based on data evaluate prognostic significance association resistance Our multi-omics studies revealed regulates influences the stemness properties of cells. Mechanistically, facilitates assembly glycolytic multi-enzyme complex, termed HGEO enhances metabolism. formation multienzyme complex comprising key enzymes including PGK1, PKM2, ENO1, LDHA, thereby facilitating production final products. refer this "HSP90-Glycolytic Output Complex" (HGEO Complex). quantified phenomenon (HGScore), finding patients high HGScore exhibited more malignant signatures, increased treatment, poorer prognoses. Furthermore, demonstrated localized nucleus, regulated nuclear lamina protein LMNA, contributes adverse outcomes. In experiments indicated inhibiting sensitizes cells chemotherapy. findings suggest LMNA mediated localization enhancing traits mechanisms cancer. Targeting pathway may offer novel strategy improve

Язык: Английский

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Huachansu suppresses colorectal cancer via inhibiting PI3K/AKT and glycolysis signaling pathways: Systems biology and network pharmacology

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119479 - 119479

Опубликована: Фев. 1, 2025

Язык: Английский

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Transplantation of gastric epithelial mitochondria into human gastric cancer cells inhibits tumor growth and enhances chemosensitivity by reducing cancer stemness and modulating gastric cancer metabolism

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 23, 2025

Язык: Английский

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Study on the Mechanism of Jieduquyuziyin prescription Improving the Condition of MRL/lpr Mice by Regulating T Cell Metabolic Reprogramming through the AMPK/mTOR Pathway

Journal of Ethnopharmacology, Год журнала: 2025, Номер 345, С. 119584 - 119584

Опубликована: Март 3, 2025

Язык: Английский

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Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Март 3, 2025

Abstract Transcriptional dysregulation is a hallmark of cancer initiation and progression, driven by genetic epigenetic alterations. Enhancer reprogramming has emerged as pivotal driver carcinogenesis, with cells often relying on aberrant transcriptional programs. The advent high-throughput sequencing technologies provided critical insights into enhancer events their role in malignancy. While targeting enhancers presents promising therapeutic strategy, significant challenges remain. These include the off-target effects enhancer-targeting technologies, complexity redundancy networks, dynamic nature reprogramming, which may contribute to resistance. This review comprehensively encapsulates structural attributes enhancers, delineates mechanisms underlying malignant transformation, evaluates opportunities limitations associated cancer.

Язык: Английский

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