Progress in Research on Inhibitors Targeting SARS-CoV-2 Main Protease (M^pro)

ACS Omega, Год журнала: 2024, Номер 9(32), С. 34196 - 34219

Опубликована: Авг. 2, 2024

Since 2019, the novel coronavirus (SARS-CoV-2) has caused significant morbidity and millions of deaths worldwide. The Coronavirus Disease 2019 (COVID-19), by SARS-CoV-2 its variants, further highlighted urgent need for development effective therapeutic agents. Currently, highly conserved broad-spectrum nature main proteases (M

Язык: Английский

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Synthesis and evolution of 16-membered macrolide carrimycin derivatives as a novel class of anti-HCoV-OC43 agents targeting viral FSE RNA

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117373 - 117373

Опубликована: Фев. 7, 2025

Язык: Английский

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Mycophenolate mofetil exerts broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2

Virology Journal, Год журнала: 2025, Номер 22(1)

Опубликована: Март 4, 2025

Язык: Английский

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The synergistic antitumour effect of Carrimycin combined with 5-fluorouracil on colorectal cancer

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 17, 2025

5-Fluorouracil (5-FU)-based chemotherapy often leads to drug resistance and adverse reactions in individuals with colorectal cancer (CRC). Carrimycin (CAM), a notable antitumour effects across various tumour types, including hepatocellular carcinoma, glioblastoma, small-cell lung offers an alternative owing its limited side effects. Combination therapy is common strategy mitigate the negative of 5-FU enhance therapeutic efficacy. This study aimed investigate potential synergistic CAM on HCT-15 HT-29 CRC cell lines. Using computational analysis, we identified quantified 5-FU. The combination significantly outperformed alone inhibiting proliferation, colony formation, cycle progression, migration. Additionally, it markedly increased levels reactive oxygen species induced DNA damage. Furthermore, RNA-seq analysis revealed that JNK p38 MAPK signalling pathways were activated by this combination. In addition, validated mouse subcutaneous graft model. conclusion, enhances sensitivity cells both vitro vivo, suggesting as promising candidate for therapy.

Язык: Английский

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Protease-Hydrolysis-Driven Approach towards the Quantification of Cellular mRNA after Drug Treatment in Protein Nanopores

Analytica Chimica Acta, Год журнала: 2025, Номер unknown, С. 343955 - 343955

Опубликована: Март 1, 2025

Язык: Английский

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Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain

Bioorganic Chemistry, Год журнала: 2024, Номер 154, С. 108086 - 108086

Опубликована: Дек. 20, 2024

Язык: Английский

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