Polymers, Год журнала: 2024, Номер 16(23), С. 3260 - 3260
Опубликована: Ноя. 23, 2024
There is a shortage in the experimental research directly comparing effectiveness of different nanoparticles boosting asparaginase (ASNase) activity. This study assessed impact various on enhancing ASNase activity, stability, and anticancer effects through immobilization.
Язык: Английский
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159276 - 159276
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 256 - 256
Опубликована: Фев. 14, 2025
Background: Neuropathic pain can be triggered by chemotherapy drugs such as paclitaxel (PTX). Management of is limited drugs' ineffectiveness and adverse effects. Isopulegol (ISO) a monoterpene present in the essential oils several aromatic plants has promising pharmacological activities. Objectives: to evaluate antinociceptive activity ISO PTX-induced neuropathic model. Methods: toxicity was evaluated healthy cancerous cells. Behavioral assessments were performed using von Frey acetone tests. We investigated involvement GABAergic pathway, NMDA, TNF-α, release GABA glutamate presence ISO. Results: showed little or no cytotoxicity U87 MDA-MB-231 In both acute subacute treatment, at doses 25, 50, 100 mg/kg (* p < 0.05) increased mechanical nociceptive threshold animals compared control group reduced thermal sensitivity. Its action reversed pre-treatment with flumazenil potentiated NMDA antagonist, MK-801. TNF-α levels tests carried out. Conclusions: shows low neuronal cells its association PTX generated synergism cytotoxic action. The effect due activation antagonism receptors involves stabilization plasma membranes leading an imbalance neurotransmitters, favoring GABA-mediated inhibition over glutamatergic excitation.
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Trends in Endocrinology and Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2025, Номер 17(7), С. 1182 - 1182
Опубликована: Март 31, 2025
Peripherally Inserted Central Catheters (PICCs) and midline catheters are crucial for chemotherapy supportive care in cancer patients. Their use requires ongoing monitoring to prevent late complications such as infections, dislodgements, replacements. The COVID-19 pandemic challenged healthcare systems, potentially increasing these due reduced outpatient services limited specialized personnel. This study compared the incidence of associated with PICCs patients during after pandemic. A retrospective observational was conducted at a Cancer Center Italy from March 2020 April 2024. Catheter-related were divided into two cohorts: (March 2020-March 2022) post-pandemic (April 2022-April 2024). primary outcome requiring device removal, categorized Statistical analyses included Chi-squared test categorical variables Kruskal-Wallis continuous variables. Of 4104 PICC catheter placements, 2291 removals recorded, 550 (24%) complications-404 146 (p < 0.001). Suspected infections most frequent complication, significantly higher Dislodgements replacements also decreased markedly post-pandemic. Limited disrupted workflows likely contributed complication rates negatively impacted management patients, complications. decline highlights importance consistent care, infection prevention, remote monitoring, stronger resilience reduce risks future crises.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2024, Номер 662, С. 124529 - 124529
Опубликована: Июль 30, 2024
Pancreatic cancer (PC) is one of the most lethal malignancies worldwide and its incidence increasing. Chemotherapy often associated to limited efficacy, poor targeting systemic toxicity. In this work, hydrophilic gemcitabine (GEM), widely used in PC treatment alone or combination, was conjugated with vitamin E succinate (VES) encapsulated Soluplus® micelles. This prodrug approach facilitated encapsulation anticancer drug into self-assembled copolymer Soluplus®/VES-GEM micelles were optimized regarding ratio components preparation process. The small-sized (<80 nm), monodisperse, highly stable, efficiently retaining conjugate showing significant antiproliferative activity against BxPC3 cell line. To improve biofunctionalization properties prepared micelles, biomimetic modification membrane further attempted by co-extruding (BxPC3) nanovesicles Several protocols prepare BxPC3-modified outcomes analyzed detail. Overall, results pave way innovative PC-targeted nanotherapies maximizing GEM hydrophobic compartments high stability affinity. also highlight need higher resolution techniques characterize coating nanocarriers bearing shells.
Язык: Английский
Процитировано
3
IntechOpen eBooks, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 21, 2024
This chapter provides a detailed overview of innovative drug delivery strategies in breast cancer therapeutics, emphasizing emerging and futuristic approaches. Current modalities, including conventional chemotherapy, targeted therapies, hormone treatments, are critically assessed regarding their mechanisms clinical efficacy. The highlights advancements systems, such as nanotechnology-based formulations, liposomal carriers, implantable devices, which enhance therapeutic effectiveness minimize systemic toxicity. Futuristic strategies, particularly precision medicine, explored for potential to tailor treatments based on genomic molecular profiling, thereby optimizing responses reducing adverse effects. role nanotechnology achieving therapeutics cells while sparing healthy tissues is examined. Additionally, gene editing technologies, CRISPR, discussed ability selectively modulate cancer-related genes, promising precise lasting also covers immunotherapeutic innovations, CAR T-cell therapy vaccines, leverage the immune system’s capacity target eliminate cells. In summary, this elucidates transformative novel cancer, highlighting integration advanced technologies foster effective, personalized treatment paradigms.
Язык: Английский
Процитировано
2
Therapeutic Delivery, Год журнала: 2024, Номер unknown, С. 1 - 17
Опубликована: Ноя. 29, 2024
To enhance the therapeutic potential of Cabozantinib (CBZ), a tyrosine kinase inhibitor with limited water solubility, low bioavailability, and high toxicity, by developing Cabozantinib-Phospholipid Complex (CBZ-PLS).
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2024, Номер 16(23), С. 3260 - 3260
Опубликована: Ноя. 23, 2024
There is a shortage in the experimental research directly comparing effectiveness of different nanoparticles boosting asparaginase (ASNase) activity. This study assessed impact various on enhancing ASNase activity, stability, and anticancer effects through immobilization.
Язык: Английский
Процитировано
0