Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1444 - 1444

Опубликована: Фев. 8, 2025

The aim of this review is to summarize the current knowledge on use coumarin-derived compounds in zebrafish (Danio rerio) model. Coumarins, a class naturally occurring with diverse biological activities, including such as coumarin, angelicin, and warfarin, have attracted considerable attention study potential therapeutic agents for cancer, central nervous system disorders, infectious diseases. capabilities coumarins active led synthesizing various derivatives their own properties. While variety certainly promising, it also cumbersome due large amount research needed find most optimal compounds. model offers unique advantages studies, high genetic physiological homology mammals, optical transparency embryos, rapid developmental processes, facilitating assessment compound toxicity underlying mechanisms action. This provides an in-depth analysis chemical properties coumarins, activity, results previous studies evaluating efficacy these assays. allows holistic coumarin derivatives, offering valuable insights advancing drug discovery development.

Язык: Английский

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Discovery of isopentenyl flavonoids with inhibitory activity against hepatocellular carcinoma cells based on DeepSAT

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114437 - 114437

Опубликована: Фев. 1, 2025

Язык: Английский

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Systematic review of natural coumarins in plants (2019–2024): chemical structures and pharmacological activities

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114480 - 114480

Опубликована: Март 1, 2025

Язык: Английский

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The complete chloroplast genome of Gerbera piloselloides (L.) Cass., 1820 (Carduoideae, Asteraceae) and its phylogenetic analysis

Open Life Sciences, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Abstract Gerbera piloselloides (L.) Cass., 1820 of the genus is importance in Chinese ethnic medicine. In this research, whole genome DNA G. was extracted and sequenced using Illumina NovaSeq platform, its chloroplast assembled annotated, sequence characteristics were analyzed bioinformatic methods. The results showed that has a length 151,871 bp contains 133 annotated genes, consisting 88 protein-coding 8 rRNA 37 tRNA genes. total, 202 simple repeat sites 43 long repeats detected , mainly mono-nucleotide tri-nucleotide repeats, with A/T as major base composition. 22,772 codons, leucine-coding codons being most abundant. Comparative genomics structure, composition variation basically same Asteraceae family. phylogenetic tree analysis indicated close relationship between Atractylodes Gerbera, consistent morphological classification. research will lay foundation for species discrimination, genetic evolution analysis, barcode construction plants.

Язык: Английский

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LC–MS coupled with diagnostic ion strategy facilitated the discovery of 5-methylcoumarin meroterpenoids from

Phytochemistry, Год журнала: 2024, Номер 229, С. 114296 - 114296

Опубликована: Окт. 2, 2024

Язык: Английский

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Cyclobrachycoumarin from Gerbera piloselloides Inhibits Colorectal Cancer In Vitro and In Vivo

Molecules, Год журнала: 2024, Номер 29(23), С. 5678 - 5678

Опубликована: Ноя. 30, 2024

, a plant in the

Язык: Английский

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Lc-Ms Coupled with Diagnostic Ion Strategy Facilitated Discovery of 5-Methylcoumarin Meroterpenoids from Gerbera Piloselloides

Опубликована: Янв. 1, 2024

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Язык: Английский

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Hot off the press

Natural Product Reports, Год журнала: 2024, Номер 41(8), С. 1214 - 1218

Опубликована: Янв. 1, 2024

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as nitidane from

Язык: Английский

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