Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Авг. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Язык: Английский
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Язык: Английский
Cuproptosis in cancer: biological implications and therapeutic opportunities
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июнь 25, 2024
Abstract
Cuproptosis,
a
newly
identified
copper
(Cu)-dependent
form
of
cell
death,
stands
out
due
to
its
distinct
mechanism
that
sets
it
apart
from
other
known
death
pathways.
The
molecular
underpinnings
cuproptosis
involve
the
binding
Cu
lipoylated
enzymes
in
tricarboxylic
acid
cycle.
This
interaction
triggers
enzyme
aggregation
and
proteotoxic
stress,
culminating
death.
specific
has
yet
be
fully
elucidated.
recognized
sparked
numerous
investigations
into
role
tumorigenesis
cancer
therapy.
In
this
review,
we
summarized
current
knowledge
on
metabolism
link
cancer.
Furthermore,
delineated
mechanisms
roles
cuproptosis-related
genes
Finally,
offered
comprehensive
discussion
most
recent
advancements
ionophores
nanoparticle
delivery
systems
utilize
as
cutting-edge
strategy
for
treatment.
Язык: Английский
Cu-Mn Nanocomposite for Enhanced Tumor Cuproptosis achieved by Remodeling the Tumor Microenvironment and Activating the Antitumor Immunogenic Responses
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Polysaccharide nanoparticles as potential immune adjuvants: Mechanism and function
Acta Pharmaceutica Sinica B,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown, С. 137337 - 137337
Опубликована: Март 1, 2025
Язык: Английский
“Trinity” Comprehensively Regulates the Tumor Microenvironment of Lipid-Coated CaCO3@CuO2 Nanoparticles Induces “Cuproptosis” in HCC
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(43), С. 58203 - 58216
Опубликована: Окт. 18, 2024
Tumor
cell
death
induced
by
"cuproptosis"
is
a
novel
form
of
tumor
that
differs
from
apoptosis
chemotherapy.
It
expected
to
emerge
as
new
approach
for
cancer
treatment.
In
this
study,
our
focus
was
on
exploiting
the
characteristic
which
necessitates
increased
aerobic
respiration
induce
death.
To
achieve
this,
we
developed
drug
delivery
system
using
CaCO3@CuO2
lipid
coating
(CaCO3@CuO2@L).
This
aimed
comprehensively
modulate
microenvironment
and
trigger
in
hepatocellular
carcinoma
(HCC)
through
interaction
between
copper
ions
peroxides.
Experimental
results
revealed
CaCO3@CuO2@L
exhibited
distinct
watermelon
shape,
with
CuO2
evenly
distributed
within
CaCO3
nanoparticles.
The
nanoparticles
had
an
average
size
approximately
191
nm.
vitro
studies
demonstrated
released
slightly
acidic
environment
while
simultaneously
elevating
pH
levels,
reducing
glutathione
(GSH),
increasing
oxygen
production.
Within
liver
cells,
effectively
regulated
acidity,
GSH
oxygen-depleted
"trinity"
mechanism,
ultimately
inducing
HCC.
Furthermore,
mouse
models
transplanted
tumors
orthotopic
tumors,
significantly
suppressed
growth.
By
triggering
HCC,
study
offers
valuable
insights
developing
comprehensive
treatment
Ultimately,
research
may
pave
way
clinical
implementation
based
Язык: Английский
Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic‐Induced Cancer Immunotherapy
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Elesclomol
(ES)
as
an
efficient
Cu
ionophore
can
specifically
transport
into
mitochondria
and
disrupt
intracellular
homeostasis.
Extra
induces
cuproptosis
chemodynamic
therapy
(CDT),
which
further
cascades
immunogenic
cell
death
(ICD)
activates
antitumor
immune
responses.
However,
the
tumor
immunosuppressive
microenvironment
(TIM)
attenuates
efficiency
of
response.
Herein,
a
biomimic
nanodrug
(ECNM)
is
fabricated,
ES,
Язык: Английский