Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
bowel
disease
with
rising
incidence
globally,
whereas
existing
treatments
exhibit
significant
limitations.
Coix
seed
polysaccharide
(CSP),
component
of
traditional
Chinese
medicine
known
for
its
immunomodulatory
and
antioxidant
properties,
has
not
been
thoroughly
investigated
role
in
UC.
In
this
study,
CSP
was
prepared
via
water
extraction
ethanol
precipitation,
protective
effects
mechanisms
were
evaluated
using
dextran
sulfate
sodium
salt
(DSS)-induced
UC
mouse
model.
The
results
demonstrated
that
significantly
ameliorated
DSS-induced
symptoms,
including
weight
loss,
an
elevated
Disease
Activity
Index,
colon
shortening,
increased
levels
cytokines,
intestinal
barrier
damage.
Moreover,
reshaped
the
gut
microbiota
dysbiosis
by
increasing
microbial
diversity
regulating
abundance
specific
genera,
such
as
Anaerotruncus.
Metabolomic
analysis
revealed
modulated
116
metabolites,
particularly
enhancing
beneficial
metabolite
3-hydroxybutyrate.
Importantly,
preventive
effect
on
dependent
could
be
transferred
fecal
transplantation.
This
study
demonstrates
CSP,
microecology-regulating
polysaccharide,
effectively
modulates
alleviates
symptoms
These
findings
support
potential
dietary
supplement
prevention
underscore
value
development
medicinal
foods
functional
food
applications.
Excessive
reactive
oxygen
species,
disruption
of
the
epithelial
barrier,
immune
dysregulation,
and
gut
microbiota
imbalance
are
key
factors
driving
onset
inflammatory
bowel
disease
(IBD)
complicating
its
treatment.
Prompt
diagnosis
diseases
precise
delivery
therapeutic
agents
to
inflamed
intestinal
sites
offer
promising
targeted
strategies
for
effectively
treating
IBD.
Here,
a
barium
sulfate-based
nanoplatform
(BaSO4@PDA@CeO2/DSP,
BPCD)
synergistic
nanozymes
drugs
was
developed.
With
enhanced
colonic
retention
after
oral
drug
delivery,
this
enables
effective
targeting
CT
imaging
guidance
address
multiple
contributing
A
comprehensive
effect
achieved
through
action
cerium
oxide
with
optimized
Ce3+/Ce4+
ratio
sustained
release
dexamethasone
sodium
phosphate.
Benefiting
from
superior
gastrointestinal
stability,
is
highly
in
IBD
by
alleviating
oxidative
stress,
modulating
macrophage
polarization
balance,
flora
composition,
repairing
barrier.
BPCD
inhibits
development
mechanisms
has
biocompatibility,
emerging
as
practical
alternative
traditional
therapies.
