Harnessing phytochemicals: innovative strategies to enhance cancer immunotherapy

Drug Resistance Updates, Год журнала: 2025, Номер 79, С. 101206 - 101206

Опубликована: Фев. 1, 2025

Cancer immunotherapy has revolutionized cancer treatment, but therapeutic ineffectiveness-driven by the tumor microenvironment and immune evasion mechanisms-continues to limit its clinical efficacy. This challenge underscores need explore innovative approaches, such as multimodal immunotherapy. Phytochemicals, bioactive compounds derived from plants, have emerged promising candidates for overcoming these barriers due their immunomodulatory antitumor properties. review explores synergistic potential of phytochemicals in enhancing modulating responses, reprogramming microenvironment, reducing immunosuppressive factors. Integrating with conventional strategies represents a novel approach mitigating resistance outcomes. For instance, nab-paclitaxel shown checkpoint inhibitors, while QS-21 synergistically enhances efficacy vaccines. Furthermore, we highlight recent advancements leveraging nanotechnology engineer improved bioavailability targeted delivery. These innovations hold great promise optimizing application phytochemicals. However, further large-scale studies are crucial fully integrate into immunotherapeutic regimens effectively.

Язык: Английский

---

The Potential Role of PD-1/PD-L1 Small Molecule Inhibitors in Colorectal Cancer with Different Mechanisms of Action

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177351 - 177351

Опубликована: Фев. 1, 2025

Язык: Английский

---

Uncovering global research frontiers in deubiquitinating enzymes and immunotherapy: A bibliometric study

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Март 25, 2025

Recently, immunotherapy has been a key therapeutic strategy for cancer. Deubiquitinating enzymes (DUBs), which are protein-modifying enzymes, have crucial role in the pathogenesis of cancer, autoimmune diseases, and inflammation. DUBs influence tumor immune microenvironment by regulating cell functions signaling pathways. Thus, potential applications piqued interest scientific community. This study performed bibliometric analysis to comprehensively examine research hotspots trends this field, providing theoretical foundations guidance future research. Studies associated with conducted over decade (2014 2024) were searched extracted from Web Science Collection database. The was using CiteSpace, VOSviewer, Bibliometrix package R software. Visualizations generated countries, institutions, authors, journals, references, keyword co-occurrences. In total, 321 articles related retrieved. number publications increased markedly since 2020. China had highest publications, while United States exerted most field. Zhang Jinfang influential author Zhejiang University institution publications. Nature cited journal (807 total citations). Keyword revealed that primary expression, immunotherapy, ubiquitination, degradation, emerging frontiers offering novel strategies application immunotherapy.

Язык: Английский

---

Demethylzeylasteral inhibits osteosarcoma cell proliferation by regulating METTL17-mediated mitochondrial oxidative phosphorylation

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117348 - 117348

Опубликована: Апрель 1, 2025

Язык: Английский

---

Small Molecule Inhibitors Targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for Cancer Immunotherapy (2020-2024)

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 283, С. 117141 - 117141

Опубликована: Дек. 5, 2024

Язык: Английский

---