Leber’s hereditary optic neuropathy and multiple sclerosis: overlap between mitochondrial disease and neuroinflammation DOI Creative Commons
Golbarg Rahimi,

Mackenzie Silverman,

Miguel Lucas

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

Although Multiple sclerosis (MS) and Leber hereditary optic neuropathy (LHON) have distinct pathophysiological mechanisms, they are both neurodegenerative conditions that involve mitochondrial dysfunction. MS is an autoimmune disease characterized by demyelination neuroinflammation; LHON a disorder predominantly affecting the nerves, resulting in severe vision loss. Recent studies highlighted coexistence of these two conditions, particularly females, suggesting variants may predispose individuals to develop or affect its progression. Similar MS, LHON-MS presents with visual impairment, neurological deficits, white matter lesions, brain atrophy, which further supports shared underlying pathophysiology. While not inherently disorder, neuroinflammatory processes can lead Reciprocally, impairment be exacerbated LHON-MS. Therefore, role dysfunction diseases central, impaired function contributing cellular damage neuroinflammation. This review explores intersections LHON, emphasizing need for research better understand disorders.

Язык: Английский

Leber’s hereditary optic neuropathy and multiple sclerosis: overlap between mitochondrial disease and neuroinflammation DOI Creative Commons
Golbarg Rahimi,

Mackenzie Silverman,

Miguel Lucas

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

Although Multiple sclerosis (MS) and Leber hereditary optic neuropathy (LHON) have distinct pathophysiological mechanisms, they are both neurodegenerative conditions that involve mitochondrial dysfunction. MS is an autoimmune disease characterized by demyelination neuroinflammation; LHON a disorder predominantly affecting the nerves, resulting in severe vision loss. Recent studies highlighted coexistence of these two conditions, particularly females, suggesting variants may predispose individuals to develop or affect its progression. Similar MS, LHON-MS presents with visual impairment, neurological deficits, white matter lesions, brain atrophy, which further supports shared underlying pathophysiology. While not inherently disorder, neuroinflammatory processes can lead Reciprocally, impairment be exacerbated LHON-MS. Therefore, role dysfunction diseases central, impaired function contributing cellular damage neuroinflammation. This review explores intersections LHON, emphasizing need for research better understand disorders.

Язык: Английский

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