Bioactive Materials, Год журнала: 2024, Номер 46, С. 229 - 241
Опубликована: Дек. 20, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101722 - 101722
Опубликована: Апрель 1, 2025
Topical instilling of commercial artificial tears (cAT, containing 0.1 % hyaluronic acid) is widely employed to alleviate clinical manifestations mild dry eye disease (DED) by preventing the pathological change corneal epithelium. However, it showed limited therapy effectiveness on heavy DED which has further involved stroma, due its low stroma-available for acid (HA) resulting from barrier The present study developed a new microneedle-dosage form cAT (cAT-MN). This cAT-MN can overstride epithelium and act as long-lasting protective agent. Compared dosing (4 times/day), with one treatment exerted significantly higher therapeutic effects curbing benzalkonium chloride (BAC)-induced stroma scaring well alleviating symptoms in first 5-day BAC exposure; whereas, 10-day exposure. To expand effects, MNs various amounts HA were prepared. Thereinto, HA(6 %)-MN recovered damage healthy levels, could be attributed adding both increasing HA-delivery enhancing HA-permeation. explores drug-free cure disorders expanded indication, promising wide use ophthalmology.
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Melanoma is a highly aggressive and metastatic malignancy, where current treatment methods often result in damage to healthy tissues, suboptimal therapeutic outcomes, immune-related side effects. Microneedles, as drug delivery system, offer advantages such localized administration, minimal invasiveness, high efficiency. In this study, we first synthesized tetradecyl-thiol-grafted PAMAM dendrimers, which significantly enhanced cellular uptake enabled sustained release of doxorubicin (DOX), improving cumulative Based on this, developed core-shell structured zwitterionic polymer-based microneedle system. The outer shell, loaded with the photothermal agent indocyanine green (ICG), achieved precise therapy under near-infrared irradiation, effectively targeting melanoma tissues. inner core, composed polymer matrix, encapsulated DOX-loaded enabling controlled prolonged through gradual swelling dendrimer expansion. Experiments show that system based grafted tetradecyl mercaptan has excellent anti protein adsorption properties, it can minimize cytotoxicity carrier improve efficiency delivery. This inhibited tumor growth synergistic photothermal-chemotherapy, reducing systemic toxicity bioavailability. platform provides promising strategy for targeted therapy, offering high-efficiency low-toxicity alternative.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 103777 - 103777
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113754 - 113754
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100529 - 100529
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2024, Номер 13(5), С. 1189 - 1198
Опубликована: Ноя. 19, 2024
We disclosed a novel transdermal donepezil delivery system using siloxane-based polymer for Alzheimer's disease treatment.
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2024, Номер 46, С. 229 - 241
Опубликована: Дек. 20, 2024
Язык: Английский
Процитировано
1