Bioengineering Approaches to In Vitro Modeling of Genetic and Acquired Cardiac Diseases DOI Creative Commons

Linqi Jin,

Boeun Hwang,

Sarah Rezapourdamanab

и другие.

Current Cardiology Reports, Год журнала: 2025, Номер 27(1)

Опубликована: Март 20, 2025

Abstract Purpose of Review This review aims to explore recent advancements in bioengineering approaches used developing and testing vitro cardiac disease models. It seeks find out how these tools can address the limitations traditional models be applied improve our understanding mechanisms, facilitate preclinical drug screening, equip development personalized therapeutics. Recent Findings Human induced pluripotent stem cells have enabled generation diverse cell types patient-specific Techniques like 3D tissue engineering, heart-on-a-chip platforms, biomechanical conditioning, CRISPR-based gene editing faithful recreation complex microenvironments conditions. These advanced study both genetic acquired disorders. Summary Bioengineered are transforming basic science clinical research cardiovascular by improving biomimicry complexity analogues, increasing throughput reproducibility screening as well offering patient specificity. Despite challenges scalability functional maturity, integrating multiple techniques with analytical modeling platforms holds promise for future precision medicine therapeutic innovations.

Язык: Английский

Bioengineering Approaches to In Vitro Modeling of Genetic and Acquired Cardiac Diseases DOI Creative Commons

Linqi Jin,

Boeun Hwang,

Sarah Rezapourdamanab

и другие.

Current Cardiology Reports, Год журнала: 2025, Номер 27(1)

Опубликована: Март 20, 2025

Abstract Purpose of Review This review aims to explore recent advancements in bioengineering approaches used developing and testing vitro cardiac disease models. It seeks find out how these tools can address the limitations traditional models be applied improve our understanding mechanisms, facilitate preclinical drug screening, equip development personalized therapeutics. Recent Findings Human induced pluripotent stem cells have enabled generation diverse cell types patient-specific Techniques like 3D tissue engineering, heart-on-a-chip platforms, biomechanical conditioning, CRISPR-based gene editing faithful recreation complex microenvironments conditions. These advanced study both genetic acquired disorders. Summary Bioengineered are transforming basic science clinical research cardiovascular by improving biomimicry complexity analogues, increasing throughput reproducibility screening as well offering patient specificity. Despite challenges scalability functional maturity, integrating multiple techniques with analytical modeling platforms holds promise for future precision medicine therapeutic innovations.

Язык: Английский

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