d-Glucose and its derivatives labeled with radioactive carbon and hydrogen: key tools for investigating biological processes and molecular mechanisms DOI Creative Commons
Fahimeh Bayat

EJNMMI Radiopharmacy and Chemistry, Год журнала: 2025, Номер 10(1)

Опубликована: Май 30, 2025

Radiolabeling is a technique that involves attaching radioactive isotopes to molecules, allowing for their tracking and analysis in biological systems. Radiolabeled D-glucose its derivatives have very prominent role exploring metabolic pathways, the enzymatic system, measuring flow of metabolites through biochemical reactions, as accumulation or deficiency occurs along with disorders. Glucose main source energy body involved different pathways like glycolysis, pentose phosphate pathway, tricarboxylic acid cycle. Various glucose are labeled at positions by 14C 3H. The aim this review summarize some most significant aspects use radiolabeled D-glucose, 2-deoxy-D-glucose, methyl-α-D-glucopyranoside. This focuses on application studying transport systems, enzyme activity, utilization across various tissues. It highlights understanding disease mechanisms diabetes, cancer, heart failure, disorders, impact pharmacological agents environmental pollutants. In conclusion, invaluable tools metabolism tissues organs. They provide critical insights into dysfunctions, mechanisms, therapeutic interventions, aiding development targeted treatments conditions cardiovascular diseases.

Язык: Английский

d-Glucose and its derivatives labeled with radioactive carbon and hydrogen: key tools for investigating biological processes and molecular mechanisms DOI Creative Commons
Fahimeh Bayat

EJNMMI Radiopharmacy and Chemistry, Год журнала: 2025, Номер 10(1)

Опубликована: Май 30, 2025

Radiolabeling is a technique that involves attaching radioactive isotopes to molecules, allowing for their tracking and analysis in biological systems. Radiolabeled D-glucose its derivatives have very prominent role exploring metabolic pathways, the enzymatic system, measuring flow of metabolites through biochemical reactions, as accumulation or deficiency occurs along with disorders. Glucose main source energy body involved different pathways like glycolysis, pentose phosphate pathway, tricarboxylic acid cycle. Various glucose are labeled at positions by 14C 3H. The aim this review summarize some most significant aspects use radiolabeled D-glucose, 2-deoxy-D-glucose, methyl-α-D-glucopyranoside. This focuses on application studying transport systems, enzyme activity, utilization across various tissues. It highlights understanding disease mechanisms diabetes, cancer, heart failure, disorders, impact pharmacological agents environmental pollutants. In conclusion, invaluable tools metabolism tissues organs. They provide critical insights into dysfunctions, mechanisms, therapeutic interventions, aiding development targeted treatments conditions cardiovascular diseases.

Язык: Английский

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