Leveraging the Shape Fidelity of 3D Printed Bone Scaffolds Through Architectural Tailoring of an Emulsion Ink: A Combined Experimental and Computational Analysis

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Abstract Hierarchical porous, bioactive, and biocompatible scaffolds with customizable multi‐functionality are promising alternatives for autografts allografts in bone tissue engineering. Combining high internal phase emulsion (HIPE) templating additive manufacturing provides possibilities to produce such multiscale porous scaffolds. 3D printing of HIPE remains a challenging task due the intense separation under shear extrusion reported printability (P r ) either less than or greater 1. Tuning viscoelastic properties is therefore required achieve P ≈1. This study addresses these issues by preparing Pickering HIPEs using dual networks synergistic viscous elastic properties, stabilized Cloisite 30B interphase. configuration enhances viscoelasticity achieves values close 1 (0.98–1.02). The printed exhibit trabecular bone‐like, hierarchical interconnected porosity (77%–86%). Computational simulations accurately predict mechanical, biological, degradation behavior. Functionalization Cissus quadrangularis bioactivates scaffolds, demonstrates vivo biocompatibility, promotes MC3T3‐E1 adhesion, proliferation, accelerates osteogenesis, reduces oxidative stress compared neat PCL work introduces facile strategy “engineering printability” regenerative materials design holds potential developing optimized engineering

Язык: Английский

Effect of Pulsed Laser Biomimetic Patterns on Surface Properties and Cell Migration of Titanium Alloys

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106621 - 106621

Опубликована: Май 1, 2025

Язык: Английский