Preparation, Optimization, and Targeted Release of Chitosan Quaternary Ammonium Salt Thermosensitive Hydrogels DOI Open Access
Juan Huang,

Y. Ye,

Sisi Fan

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(7)

Опубликована: Фев. 1, 2025

Abstract Chitosan (CS) exhibits a wide range of physicochemical properties in gel forms. In this work, the quaternized chitosan, N ‐[(2‐hydroxy‐3‐trimethylammonium)propyl] chitosan chloride (HTCC), was successfully synthesized and blended with CS glycerophosphate (GP) to form thermosensitive hydrogel. The HTCC exhibited degree quaternization 78.52% improved water solubility (5.7%, w/v). For hydrogel composed 1.57% CS, 0.23% HTCC, 10% GP (w/v), sol‐to‐gel transition occurred within 2 min at 40 °C. Notably, when concentration reached approximately 6% CS‐HTCC‐GP unique biphasic behavior, transitioning from sol either by cooling room temperature 5 °C or heating NaCl release behavior influenced both pH temperature, faster observed under weakly basic conditions compared neutral acidic environments. process followed quasi‐Fickian diffusion mechanism. These distinctive suggest that holds great promise not only for controlled drug applications but also uses hemostasis embolization.

Язык: Английский

Understanding Protein Adsorption on Carbon Nanotube Inner and Outer Surfaces by Molecular Dynamics Simulations DOI
Qu Chen,

Linkai Yu,

Xiaoyu Han

и другие.

Langmuir, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Biomolecules, such as proteins, can form complexes with carbon nanotubes (CNTs), which have numerous applications in nanobiotechnology. Proteins be adsorbed onto either the inner walls or outer surfaces of CNTs via van der Waals interactions; however, differences between these two processes remain poorly understood. In this work, we performed classical all-atom molecular dynamics simulations explicit solvents to investigate interaction a model protein, Yap65 WW domain, and (22,22) larger. The domain comprises three β-sheet segments contains key aromatic residues: TRP17, TYR28, TRP39. Our findings reveal distinct mechanisms for large CNTs. protein's surface is governed by interplay curvature adsorption orientation. confined space CNT channel, variations tube orientation give rise specific binding modes, resulting varying degrees protein conformational change. contrast, on CNTs, where less restricted, plays more dominant role. Specifically, residues directly interact suffer from greater structural loss, regardless curvature. Finally, protein-CNT free energies were calculated using Poisson-Boltzmann area (MM-PBSA) method steered based Jarzynski equality, demonstrating that desorption highly dependent configurations. This study reveals influence critical role modulating stability.

Язык: Английский

Процитировано

1
Preparation, Optimization, and Targeted Release of Chitosan Quaternary Ammonium Salt Thermosensitive Hydrogels DOI Open Access
Juan Huang,

Y. Ye,

Sisi Fan

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(7)

Опубликована: Фев. 1, 2025

Abstract Chitosan (CS) exhibits a wide range of physicochemical properties in gel forms. In this work, the quaternized chitosan, N ‐[(2‐hydroxy‐3‐trimethylammonium)propyl] chitosan chloride (HTCC), was successfully synthesized and blended with CS glycerophosphate (GP) to form thermosensitive hydrogel. The HTCC exhibited degree quaternization 78.52% improved water solubility (5.7%, w/v). For hydrogel composed 1.57% CS, 0.23% HTCC, 10% GP (w/v), sol‐to‐gel transition occurred within 2 min at 40 °C. Notably, when concentration reached approximately 6% CS‐HTCC‐GP unique biphasic behavior, transitioning from sol either by cooling room temperature 5 °C or heating NaCl release behavior influenced both pH temperature, faster observed under weakly basic conditions compared neutral acidic environments. process followed quasi‐Fickian diffusion mechanism. These distinctive suggest that holds great promise not only for controlled drug applications but also uses hemostasis embolization.

Язык: Английский

Процитировано

0