Assessing Reproductive Effects and Epigenetic Responses in Austrolebias charrua Exposed to Roundup Transorb®: Insights from miRNA Profiling and Molecular Interaction Analysis DOI

Antônio Duarte Pagano,

Leandro S. Nunes, William Borges Domingues

и другие.

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 110, С. 104539 - 104539

Опубликована: Авг. 23, 2024

Язык: Английский

Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead DOI

Xiaoping Xie,

Kexin Wang,

Xiaoyan Shen

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 475, С. 134854 - 134854

Опубликована: Июнь 7, 2024

Язык: Английский

Процитировано

1
Research Progress on Micro (Nano)Plastics Exposure-Induced miRNA-Mediated Biotoxicity DOI Creative Commons
Ting Chen,

Qizhuan Lin,

Changyong Gong

и другие.

Toxics, Год журнала: 2024, Номер 12(7), С. 475 - 475

Опубликована: Июнь 29, 2024

Micro- and nano-plastics (MNPs) are ubiquitously distributed in the environment, infiltrate organisms through multiple pathways, accumulate, thus posing potential threats to human health. MNP exposure elicits changes microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular (circRNAs), thereby precipitating immune, neurological, other toxic effects. The investigation of its effect on miRNA expression has garnered increasing attention. Following exposure, circRNAs serve as sponges by modulating gene expression, while lncRNAs function competing endogenous (ceRNAs) fine-tuning target consequently impacting protein translation physiological processes cells. Dysregulated mediates mitochondrial dysfunction, inflammation, oxidative stress, risk neurodegenerative diseases, cardiovascular cancer. This tract, blood, urine, feces, placenta, review delves into biotoxicity arising from dysregulated due addresses challenges encountered this field. study provides novel insights connections between MNPs disease risk.

Язык: Английский

Процитировано

1
High-fat intake induces gut microbiota disorders, inflammatory responses and oxidative stress in Nyctereutes procyonoides DOI Creative Commons
Zhaoming Li,

Chengwei Wei,

Jie Yang

и другие.

Animal Diseases, Год журнала: 2024, Номер 4(1)

Опубликована: Авг. 6, 2024

Abstract The Nyctereutes procyonoides is highly regarded in the farming and leather industries because of high value its fur, which renders artificial feeding a crucial aspect. However, high-fat diets have always been associated with variety digestive disorders. This study aimed to investigate impact on gut microbiota mechanisms damage . 16S rRNA sequencing demonstrated that caused diarrhea intestinal through alterations microbiota: decrease abundance Firmicutes, an increase Proteobacteria Actinobacteria , Enterococcaceae Escherichia coli-Shigella Clostridium Lactobacillus Subsequently, changes metabolic pathways, such as amino fatty acid were identified by KEGG COG enrichment analysis, TLR4/NF-κB/NLRP3 inflammatory signaling pathway was shown be activated diets. In addition, lead accumulation ROS MDA reduce activity antioxidant enzymes GSH-PX SOD. Correspondingly, levels proinflammatory cytokines (IL-6, IL-1β TNF-α) significantly increased, apoptosis necrosis pathways colonic cells detected, causing dramatic expression tight junction proteins (Occludin, E-cadherin, ZO-1 ZO-2). conclusion, altered structure community led colon damage. provides new insights into health Graphical

Язык: Английский

Процитировано

1
Assessing Reproductive Effects and Epigenetic Responses in Austrolebias charrua Exposed to Roundup Transorb®: Insights from miRNA Profiling and Molecular Interaction Analysis DOI

Antônio Duarte Pagano,

Leandro S. Nunes, William Borges Domingues

и другие.

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 110, С. 104539 - 104539

Опубликована: Авг. 23, 2024

Язык: Английский

Процитировано

1