Food Science & Nutrition,
Год журнала:
2024,
Номер
13(1)
Опубликована: Дек. 31, 2024
ABSTRACT
Coumarins,
a
group
of
naturally
occurring
compounds,
have
been
reported
to
demonstrate
anticancer
potential.
These
substances,
distinguished
by
their
combined
benzene
and
α‐pyrone
rings,
demonstrated
impact
multiple
cellular
mechanisms
essential
for
the
initiation
advancement
cancer.
agents
work
in
different
ways
that
prevent
tumor
cells
from
growing,
spreading,
increasing.
One
main
coumarin
act
is
killing
cancer
through
apoptosis.
This
includes
changes
pro‐
anti‐apoptotic
proteins
like
Bcl‐2
Bax,
release
cytochrome
c
mitochondria,
activation
caspases.
The
suppressor
protein
p53's
expression
has
discovered
be
upregulated
coumarins
such
as
esculetin
imperatorin,
which
encourage
interrupted
cell
cycle
death.
Additionally,
anti‐angiogenic
qualities,
are
critical
development
spread
tumors.
It
can
slow
new
blood
vessels
feed
tumors
inhibiting
“vascular
endothelial
growth
factor
(VEGF)”
route
signaling.
Coumarins
inhibit
number
signaling
pathways
vital
division.
For
example,
they
suppress
“PI3K/mTOR”
pathway,
usually
impairs
results
decreased
viability
growth.
Finally,
could
modulate
response
immune
system
cancerous
cells.
They
ability
boost
activity
natural
killer
cytotoxic
T
lymphocytes,
aid
identifying
eliminating
Through
variety
mechanisms,
regulation,
angiogenesis
reduction,
inhibition,
apoptosis
activation,
exhibit
effects.
molecular
coumarins'
potential
an
interesting
option
novel
treatments.
More
studies
needed
completely
understand
modes
action
maximize
therapeutic
efficacy.
Green Chemistry Letters and Reviews,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 23, 2024
Herein,
a
rapid,
clean,
less
expensive
and
environmentally
friendly
route
to
novel
series
of
coumarins
bearing
thiazoles
or
1,3,4-thiadiazoles
was
developed
via
grinding
method
under
solvent
conditions.
Thus,
6-bromo-3-(2-bromoacetyl)-2-chromen-2-one
treated
with
cyanothioacetamide
produce
thiazole-2-acetonitrile
derivative
2,
which
then
transformed
iminocoumarins
by
reacting
hydroxyaldehydes.
Hydrolysis
conc.
HCl
furnished
coumarins.
Furthermore,
treatment
compound
2
phenylisothiocyanate
produced
thioanilide
interacts
hydrazonoyl
chloride
and/or
α-halocarbonyl
compounds
afforded
1,3,4-thiadiazole
thiophene
derivatives,
consequently.
All
the
newly
prepared
were
screened
against
six
pathogenic
microorganisms.
The
results
indicated
that
7
12
most
effective
Bacillus
pumilis,
while
4b
highly
active
Streptococcus
faecalis.
Also,
5b
Enterobacter
cloacae.
Compounds
higher
compared
reference
drug
ketoconazole
fungi
Saccharomyces
cerevisiae.
Food Science & Nutrition,
Год журнала:
2024,
Номер
13(1)
Опубликована: Дек. 31, 2024
ABSTRACT
Coumarins,
a
group
of
naturally
occurring
compounds,
have
been
reported
to
demonstrate
anticancer
potential.
These
substances,
distinguished
by
their
combined
benzene
and
α‐pyrone
rings,
demonstrated
impact
multiple
cellular
mechanisms
essential
for
the
initiation
advancement
cancer.
agents
work
in
different
ways
that
prevent
tumor
cells
from
growing,
spreading,
increasing.
One
main
coumarin
act
is
killing
cancer
through
apoptosis.
This
includes
changes
pro‐
anti‐apoptotic
proteins
like
Bcl‐2
Bax,
release
cytochrome
c
mitochondria,
activation
caspases.
The
suppressor
protein
p53's
expression
has
discovered
be
upregulated
coumarins
such
as
esculetin
imperatorin,
which
encourage
interrupted
cell
cycle
death.
Additionally,
anti‐angiogenic
qualities,
are
critical
development
spread
tumors.
It
can
slow
new
blood
vessels
feed
tumors
inhibiting
“vascular
endothelial
growth
factor
(VEGF)”
route
signaling.
Coumarins
inhibit
number
signaling
pathways
vital
division.
For
example,
they
suppress
“PI3K/mTOR”
pathway,
usually
impairs
results
decreased
viability
growth.
Finally,
could
modulate
response
immune
system
cancerous
cells.
They
ability
boost
activity
natural
killer
cytotoxic
T
lymphocytes,
aid
identifying
eliminating
Through
variety
mechanisms,
regulation,
angiogenesis
reduction,
inhibition,
apoptosis
activation,
exhibit
effects.
molecular
coumarins'
potential
an
interesting
option
novel
treatments.
More
studies
needed
completely
understand
modes
action
maximize
therapeutic
efficacy.
