Current Computer - Aided Drug Design, Год журнала: 2023, Номер 20(7), С. 1113 - 1129
Опубликована: Окт. 19, 2023
In China, Niuxi-Mugua formula (NMF) has been widely used to prevent and treat coronavirus disease 2019 (COVID-19). However, the mechanism of NMF for treating COVID-19 is not yet fully understood.
Язык: Английский
International Journal of Food Properties, Год журнала: 2025, Номер 28(1)
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
Life, Год журнала: 2024, Номер 14(6), С. 656 - 656
Опубликована: Май 22, 2024
The global prevalence of obesity is a pressing health issue, increasing the medical burden and posing significant risks to humans. side effects complications associated with conventional medication surgery have spurred search for anti-obesity drugs from plant resources. Previous studies suggested that Artemisiae argyi Folium (Aiye) water extracts could inhibit pancreatic lipase activities, control body weight increase, improve plasma lipids profile. However, exact components mechanisms were not precisely understood. Therefore, this research aims identify chemical profile Aiye provide comprehensive prediction its mechanisms. extract was subjected LC-MS analysis, which identified 30 phenolics. these phenolics then predicted, employing network pharmacology molecular docking. Among phenolics, 21 passed drug-likeness screening exhibited 486 targets. enrichment analysis revealed may combat through PI3K-Akt signaling MAPK, prolactin, cAMP pathways. Eight seven central targets selected docking, 45 out 56 docking had binding affinity less than −5 kcal/mol. This has indicated potential therapy pathways in combating obesity.
Язык: Английский
Процитировано
2
Metabolites, Год журнала: 2023, Номер 13(11), С. 1151 - 1151
Опубликована: Ноя. 15, 2023
It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. However, mechanism MF EC against immunosuppression remains unclear. This study aims to explore action for through network pharmacology, molecular docking, dynamics simulations animal experiments. As a result, 11 critical components, 9 hub targets, related signaling pathways were obtained based on pharmacology. The docking suggested components exhibited great binding affinity targets results showed (-)-tabernemontanine-AR, beta-sitosterol-AR Dehydrodieugenol-HSP90AA1 complexes are stably bound. Additionally, experiments, treated group compared control suggest have significant effect Therefore, may take multi-component, multi-target, multi-pathway manner. herein provide novel insights into humans.
Язык: Английский
Процитировано
3
Опубликована: Окт. 17, 2023
It’s been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects on the treatment of immunosuppression. However, mechanism MF EC against immunosuppression remains unclear. This study aims to explore action for through network pharmacology, molecular docking, dynamics simulations animal experiments. As a result, 11 critical components, 9 hub targets, related-signaling pathways were obtained based pharmacology. The docking suggested components exhibited great binding affinity targets results showed (-)-Tabernemontanine-AR, beta-sitosterol-AR Dehydrodieugenol-HSP90AA1 complexes are stably bound. Additionally, in experiments, treated group compared control suggest have significant effect Therefore, may take multi-component, multi-target, multi-pathway manner. would provide novel insights into humans.
Язык: Английский
Процитировано
1
Current Computer - Aided Drug Design, Год журнала: 2023, Номер 20(7), С. 1113 - 1129
Опубликована: Окт. 19, 2023
In China, Niuxi-Mugua formula (NMF) has been widely used to prevent and treat coronavirus disease 2019 (COVID-19). However, the mechanism of NMF for treating COVID-19 is not yet fully understood.
Язык: Английский
Процитировано
0