Pest Management Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 12, 2024
A large number of pathogenic fungi have caused serious damage to the global crop yield, and drug resistance is always a topic that cannot be avoided for traditional fungicides. Therefore, finding efficient, green, low-toxic fungicides our primary task, which brings opportunities development natural product green pesticides.
Язык: Английский
ACS Omega, Год журнала: 2024, Номер unknown
Опубликована: Апрель 5, 2024
In order to discover novel compounds with excellent agricultural activities, flavonol derivatives containing 1,3,4-thiadiazole were synthesized and evaluated for their antifungal activities. The bioassay results showed that some of the target had good activities against Botrytis cinerea, Phomopsis sp. Sclerotinia sclerotiorum in vitro. It is worth noting half-effective concentration (EC50) value Y18 B. cinerea was 2.4 μg/mL, which obviously superior azoxystrobin (21.7 μg/mL). curative activity at 200 μg/mL (79.9%) better than (59.1%), its protective (90.9%) (83.9%). Morphological studies by using scanning electron microscopy fluorescence revealed could affect normal growth mycelium. addition, mechanism action indicated integrity cell membranes inducing production endogenous reactive oxygen species release malondialdehyde content, leading membrane lipid peroxidation contents. inhibitory on plant fungi notable, offering significant potential development new agents.
Язык: Английский
Процитировано
11
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(18), С. 10227 - 10235
Опубликована: Апрель 26, 2024
In this study, 24 indole derivatives containing 1,3,4-thiadiazole were discovered and synthesized. The target compounds' antifungal efficacy against 14 plant pathogenic fungal pathogens was then determined in vitro. With an EC50 value of 2.7 μg/mL, Z2 demonstrated the highest level bioactivity among them Botrytis cinerea (B.c.), exceeding concentrations control prescription drugs azoxystrobin (Az) (EC50 = 14.5 μg/mL) fluopyram (Fl) 10.1 μg/mL). underwent vivo testing on blueberry leaves order to evaluate its usefulness real-world settings. A reasonable protective effect obtained with a effectiveness 93.0% at 200 which superior those Az (83.0%) Fl (52.0%). At chemical had 84.0% terms curative efficacy. These figures outperformed (69.0%) (48.0%). Scanning electron microscopy (SEM) experiments light showed that altered integrity cell wall membrane fungus B.c., led increase content malondialdehyde (MDA), cellular leakage, permeability. Enzyme activity assays molecular docking studies indicated could act as potential succinate dehydrogenase inhibitor (SDHI). It hypothesized cause disruption mycelial membranes, turn leads death. According research, expected evolve into new fungicides due their significant effects fungi.
Язык: Английский
Процитировано
11
Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(5), С. 105758 - 105758
Опубликована: Март 26, 2024
In this study, 21 indole derivatives containing 1,3,4-oxadiazole were designed and synthesized, the results of biological activity test showed that target compound had certain antifungal against 12 plant pathogenic fungi in vitro, among which. E1 excellent bioactivity Botrytis cinerea (B.c.), Tomato (F.M.) Phomopsis sp (P.s.), with median effective concentration (EC50) values 2.8, 5.1 5.2 µg/mL, which are higher than those control drug azoxystrobin (Az) at 15.2, 31.2 15.2 µg/mL. vivo tests on blueberry leaves, tomato leaves kiwifruit 200 µg/mL offered stronger protective effect B.c. (91.9 %) Az (83.8 F.M. (83.3 (72.9 P.s. (89.3 (86.9 kiwifruit. Scanning electron microscope (SEM) experiments hyphae treated abnormal shrinkage obvious morphological changes. The mechanism study could change integrity cell wall membrane pathogen B.c., led to increase malondialdehyde (MDA), leakage permeability rupture membrane. Because their strong effects fungus, predicted develop into novel fungicides.
Язык: Английский
Процитировано
8
Journal of Saudi Chemical Society, Год журнала: 2023, Номер 28(2), С. 101797 - 101797
Опубликована: Дек. 23, 2023
A series of flavonoid derivatives containing 1,2,4-triazolo[4,3-a]pyridine were designed, synthesized and evaluated for their antifungal activity. Bioactivity tests showed that some target compounds exhibited the strong activity against Botrytis cinerea (B. cinerea), Sclerotinia sclerotiorum (S. sclerotiorum), Phomopsis sp. Among them, half maximal effective concentration (EC50) value S2 B. was 3.3 μg/mL, which less than control drug azoxystrobin (21.0 μg/mL). The EC50 S. 12.7 better (28.1 In addition, in vivo protective curative activities blueberry 92.0 79.8 % at 200 respectively, higher those (89.4 71.7%). Scanning electron microscopy (SEM) spore germination experiments could not only cause mycelium damage but also inhibited germination. Fluorescence (FM) observation, relative electrical conductivity measurement cytoplasmic leakage assays indicated affect cell membrane integrity by inducing lipid peroxidation increasing permeability as well causing contents. These results show had excellent inhibitory effects on cinerea, providing another supplement development new pesticides.
Язык: Английский
Процитировано
17
Journal of Molecular Structure, Год журнала: 2024, Номер 1307, С. 138061 - 138061
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
7
Molecules, Год журнала: 2024, Номер 29(10), С. 2247 - 2247
Опубликована: Май 10, 2024
This review article is a comprehensive and current overview on chalcones, covering their sources, identification methods, properties with particular focus applications in the agricultural sector. The widespread use of synthetic pesticides has not only led to increased resistance among weeds pests, resulting economic losses, but it also raised significant health concerns due overuse these chemicals. In line European Green Deal 2030 its Farm Fork strategy, there targeted 50% reduction chemical by 2030, emphasizing shift towards natural alternatives that are more environmentally sustainable help restoration resources. Chalcones derivatives, herbicidal, fungicidal, bactericidal, antiviral properties, appear be ideal candidates. These naturally occurring compounds have been recognized for beneficial effects many years across multiple areas. complements previous literature chalcones provides updates introduces methods detection such as chromatography MALDI technique.
Язык: Английский
Процитировано
7
Опубликована: Апрель 1, 2024
This review provides a comprehensive and updated information on chalcones, presenting their sources, methods of identification properties putting emphasis applications in agricultural industry. Vast exploitation synthetic pesticides led to the weed pest resistance issue, causing economic loss but more importantly health risk due pesticide overuse. Because one aim European Green Deal 2030 is Farm Fork strategy which targets reducing by 50% use chemical 2030, push towards natural are environmentally friendly restore resources, chalcones derivatives seem fit perfectly. They have herbicidal, fungicidal, bactericidal antiviral properties. Moreover, naturally occurring substances, known for favorable effect years, working many areas. complementary previous ones describing agriculture, updates them additionally shows detection.
Язык: Английский
Процитировано
6
Journal of Saudi Chemical Society, Год журнала: 2023, Номер 27(6), С. 101773 - 101773
Опубликована: Ноя. 1, 2023
28 chalcone derivatives containing thiazole fragment were synthesized. The results of antifungal bioactivity tests suggested that most the compounds possessed superior in vitro activities against nine plant pathogenic fungi. T17 showed excellent Sclerotinia sclerotiorum (S. sclerotiorum) with an EC50 value 12.9 μg/mL, which was better than azoxystrobin (15.1 μg/mL). Further that, T11 exhibited good Phytophthora capsici (P. capsici) 15.8 to (40.2 test carried out oilseed rape vivo. protective and curative on infected S. 86.5 75.2%, respectively, higher those (71.4 68.6%) at 200 μg/mL. Scanning electron microscopy indicated mycelium collapsed folded after treatment, changed mycelial morphology, inhibiting growth mycelium, thus achieving inhibitory effect sclerotiorum. In addition, mechanism action studies manifested further verified by performing vivo activity assay, fluorescence microscopy, light cell membrane permeability, leakage cellular contents, malondialdehyde content assay. This study demonstrates compound has potential become a novel fungicide.
Язык: Английский
Процитировано
12
Arabian Journal of Chemistry, Год журнала: 2023, Номер 17(1), С. 105368 - 105368
Опубликована: Окт. 18, 2023
In this study, 24 chalcone derivatives containing benzoxazole were designed and synthesized, the structures of all target compounds confirmed by NMR HRMS. The results antibacterial activity showed that median effective concentration (EC50) value Z2 against Xanthomonas oryzae pv.oryzae (Xoo) was 8.10 μg/mL, which better than thiodiazole copper (60.62 μg/mL), verified scanning electron microscopy (SEM). Antibacterial mechanism on Xoo preliminarily explored, concentrations 100, 50 mg/L, had a good cell membrane permeability to can inhibit EPS content production extracellular enzymes, affecting formation biofilm, preliminary validation effect Xoo. At 200 protective harvested potatoes, comparable with copper. tobacco mosaic virus (TMV) determined half leaf dry spot method. EC50 curative Z15 101.97 superior ningnanmycin (NNM) 294.27 Z16 104.05 NNM 185.73 μg/mL. Molecular docking Z15, significantly higher affinity coat protein (TMV-CP) NNM. above indicated have potential become antivirial agents.
Язык: Английский
Процитировано
11
Coordination Chemistry Reviews, Год журнала: 2024, Номер 523, С. 216285 - 216285
Опубликована: Ноя. 2, 2024
Язык: Английский
Процитировано
4