Longitudinal patterns of brain aging and neurodegeneration among older adults with dual decline in memory and gait
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(2)
Опубликована: Фев. 1, 2025
Abstract
INTRODUCTION
Dual
cognitive
and
mobility
decline
is
more
strongly
associated
with
dementia
risk
than
only.
It
remains
unknown
whether
this
syndrome
brain
atrophy
patterns,
white
matter
(WM)
damage,
or
pathology.
METHODS
In
the
Baltimore
Longitudinal
Study
of
Aging
participants
without
dual
decline,
we
used
linear
mixed‐effects
models
to
compare
up
13‐year
longitudinal
changes
in
MRI‐derived
WM
hyperintensities
(
n
=
339),
microstructure
307),
plasma
glial
fibrillary
acidic
protein
(GFAP),
neurofilament
light
chain
(NfL),
amyloid
beta
42/40
(Aβ
)
ratio
349),
phosphorylated
tau
181
(pTau181)
258).
RESULTS
Those
experiencing
showed
accelerated
medial
temporal
p
.004),
parietotemporal
.029),
perisylvian
regions
.028),
whereas
gait
only
.035)
memory
.021).
was
also
unique
microstructural
deterioration
several
tracts
<
.05),
a
greater
decrease
Aβ
.015),
increases
GFAP
.009)
NfL
.001).
DISCUSSION
Individuals
are
at
an
increased
for
regional
atrophy,
degradation,
biomarker‐defined
molecular
underlying
dementia.
Highlights
patterns.
deterioration.
ratio.
NfL.
may
indicate
blood
markers
Язык: Английский
Relationship between Subjective Grip Strength and Physical Functioning among Community-Dwelling Older Women
Geriatrics,
Год журнала:
2024,
Номер
9(3), С. 68 - 68
Опубликована: Май 26, 2024
This
study
investigated
the
relationship
between
subjective
grip
strength
and
physical
function
in
community-dwelling
older
women.
Subjective
was
assessed
using
a
questionnaire,
body
composition
were
compared
groups
with
strong
weak
strength.
Additionally,
two
those
mild
cognitive
impairment
(MCI)
normal
function,
respectively.
The
results
showed
significant
differences
(p
<
0.001),
30
s
chair–stand
(CS-30)
test
=
0.039),
timed
up-and-go
(TUG)
0.027),
maximal
gait
speed
0.029),
skeletal
muscle
mass
0.001).
Older
adults
quadriceps
0.009),
one-leg
standing
time
0.041),
CS-30
0.002),
TUG
0.014),
0.006),
0.003).
low
had
lower
mass.
However,
no
items
among
MCI.
Thus,
is
an
indicator
of
overall
decline
reduction
adults,
should
be
considered
when
assessing
adults.
Язык: Английский