Association between Hp infection and serum uric acid to high-density lipoprotein cholesterol ratio in adults

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 13, 2025

Background Helicobacter pylori (Hp) infection is one of the major global health problems resulting in multiple system disorders. The serum uric acid to high density lipoprotein cholesterol ratio (UHR) a novel index inflammation and metabolism, but its association with development Hp still unclear. Materials methods This cross-sectional study involving 2,666 participants, using data from National Health Nutrition Examination Survey (NHANES) conducted United States. relationship between UHR was evaluated by multivariate logistic regression sensitivity analysis enhance stability results. Results Among all individuals, 1,165 were positive (43.7%) 1,501 negative (56.3%). After adjustment, there correlation (OR = 1.15; 95% CI 1.02–1.30; P 0.020). relatively stable subgroup ( > 0.05). Conclusion There our study. non-invasive indicator can improve ability monitor may find alternative therapeutic intervention targets.

Язык: Английский

Elevated log uric acid-to-high-density lipoprotein cholesterol ratio (UHR) as a predictor of increased female infertility risk: insights from the NHANES 2013–2020

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 1, 2025

Infertility is a multifaceted condition influenced by metabolic and biochemical factors. Uric acid (UA) high-density lipoprotein cholesterol (HDL-C) may individually affect reproductive health. The UA-to-HDL-C ratio (UHR), an emerging indicator of chronic inflammation status, be associated with infertility because its connections to disorders, disrupted processes, other related Nevertheless, evidence the relationship between UHR remains limited controversial. Therefore, potential associations were analyzed in this study. In cross-sectional study, data from 2013-2020 National Health Nutrition Examination Survey (NHANES) utilized, nationally representative survey assessing health nutritional status U.S. Female participants aged 18-45 years (n = 6502) whose was determined through self-reported responses questions included. primary outcome infertility, defined on basis indicating difficulty conceiving over past year. Between-group differences via Student's t test or Mann‒Whitney U for continuous variables chi-square categorical data. independent association log assessed computes logarithms default natural logarithms. Subgroup analyses performed assess strength results. mean women group significantly greater than that noninfertility (5.34 vs. 5.22, P < 0.001). Adjusted revealed increase odds (odds (OR) 1.830, 95% confidence interval (CI) 1.396-2.401). analysis younger 35 elevated faced even risk (OR 2.716, CI 1.784-4.162; An higher knowledge beneficial developing nonpharmacological intervention improving fertility outcomes. Further research needed clarify direct impact female which could inform future strategies prevention treatment.

Язык: Английский

Association between the uric acid-to-HDL-cholesterol ratio (UHR) and the risk of cardiovascular disease and dyslipidemia: a population-based study

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 16, 2025

Язык: Английский