ACOT1 eQTL: a gene involved in lipid metabolism that modulates erectile dysfunction progression via metabolites DOI Creative Commons
Zelin Zhang, Yingfei Chen, Yi Wang

и другие.

Archives of Medical Science, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Introduction The causal relationship between expression quantitative trait loci (eQTL) and erectile dysfunction (ED) remains underexplored. This study applied Mendelian randomization (MR) analysis to investigate potential links novel susceptibility genes for ED their underlying mechanisms. Material methods Two-sample MR was employed examine connections eQTLs, metabolites, progression. Furthermore, summary-data-based (SMR) used validate the association cis-eQTLs ED. A castrated rat model also established gene via real-time polymerase chain reaction (qRT-PCR). Results results provide evidence that ACOT1 eQTL promoted SMR confirmed a cis-eQTL progression (p < 0.05). Regarding ACOT1’s role in ED, suggested may negatively regulate docosadioate (C22-DC) octadecanedioylcarnitine (C18−DC), both of which inhibited In SD rats, castration led decrease ratio intracavernous pressure (ICP) mean arterial (MAP) reduction smooth muscle collagen, accompanied by an increase -SMA group. These findings confirm successful establishment model. Additionally, further revealed significant upregulation group Conclusions study, first time, elucidates mechanisms ACOT1, as eQTL-mediated gene, accelerates regulating levels (C18-DC) metabolites. insights offer new therapeutic targets

Язык: Английский

ACOT1 eQTL: a gene involved in lipid metabolism that modulates erectile dysfunction progression via metabolites DOI Creative Commons
Zelin Zhang, Yingfei Chen, Yi Wang

и другие.

Archives of Medical Science, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Introduction The causal relationship between expression quantitative trait loci (eQTL) and erectile dysfunction (ED) remains underexplored. This study applied Mendelian randomization (MR) analysis to investigate potential links novel susceptibility genes for ED their underlying mechanisms. Material methods Two-sample MR was employed examine connections eQTLs, metabolites, progression. Furthermore, summary-data-based (SMR) used validate the association cis-eQTLs ED. A castrated rat model also established gene via real-time polymerase chain reaction (qRT-PCR). Results results provide evidence that ACOT1 eQTL promoted SMR confirmed a cis-eQTL progression (p < 0.05). Regarding ACOT1’s role in ED, suggested may negatively regulate docosadioate (C22-DC) octadecanedioylcarnitine (C18−DC), both of which inhibited In SD rats, castration led decrease ratio intracavernous pressure (ICP) mean arterial (MAP) reduction smooth muscle collagen, accompanied by an increase -SMA group. These findings confirm successful establishment model. Additionally, further revealed significant upregulation group Conclusions study, first time, elucidates mechanisms ACOT1, as eQTL-mediated gene, accelerates regulating levels (C18-DC) metabolites. insights offer new therapeutic targets

Язык: Английский

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