Frontiers in Aging Neuroscience,
Год журнала:
2023,
Номер
15
Опубликована: Май 26, 2023
Neurodegenerative
diseases
have
reached
alarming
numbers
in
the
past
decade.
Unfortunately,
clinical
trials
testing
potential
therapeutics
proven
futile.
In
absence
of
disease-modifying
therapies,
physical
activity
has
emerged
as
single
most
accessible
lifestyle
modification
with
to
fight
off
cognitive
decline
and
neurodegeneration.
this
review,
we
discuss
findings
from
epidemiological,
clinical,
molecular
studies
investigating
modifications
promoting
brain
health.
We
propose
an
evidence-based
multidomain
approach
that
includes
activity,
diet,
training,
sleep
hygiene
treat
prevent
neurodegenerative
diseases.
Sports Medicine and Health Science,
Год журнала:
2019,
Номер
1(1), С. 3 - 10
Опубликована: Сен. 25, 2019
Chronic
diseases
are
the
leading
cause
of
death
worldwide
with
increasing
prevalence
in
all
age
groups,
genders,
and
ethnicities.
Most
chronic
disease
deaths
occur
middle-to
low-income
countries
but
also
a
significant
health
problem
developed
nations.
Multiple
now
affect
children
adolescents
as
well
adults.
Being
physically
inactive
is
associated
increased
risk.
Global
societies
being
negatively
impacted
by
which
directly
related
to
rising
healthcare
expenditures,
workforce
complications
regarding
attendance
productivity,
military
personnel
recruitment,
academic
success.
However,
physical
activity
(PA)
exercise
reduced
physiologic
systems
body
benefit
positively
from
PA
primary
prevention
secondary
prevention/treatment.
The
purpose
this
brief
review
describe
global
for
adults
children,
how
can
provide
non-invasive
means
added
treatment.
Frontiers in Aging Neuroscience,
Год журнала:
2021,
Номер
12
Опубликована: Янв. 18, 2021
Previous
studies
showed
that
quarantine
for
pandemic
diseases
is
associated
with
several
psychological
and
medical
effects.
The
consequences
of
COVID-19
in
patients
dementia
are
unknown.
We
investigated
the
clinical
changes
Alzheimer's
disease
other
dementias,
evaluated
caregivers'
distress
during
quarantine.
Sports Medicine,
Год журнала:
2024,
Номер
54(5), С. 1179 - 1205
Опубликована: Янв. 25, 2024
Abstract
Background
Physical
activity
is
known
to
improve
psychological
and
cognitive
outcomes.
Learning
dance
sequences
may
challenge
cognition,
partnered
or
group
benefit
social
interactions,
the
artistic
aspect
wellbeing.
Dance
an
equally
effective
form
of
physical
compared
with
other
structured
activities
health,
but
it
unclear
how
could
be
for
outcome
measures.
Objective
To
systematically
review
literature
on
effectiveness
interventions,
exercise
programmes,
outcomes
across
lifespan.
Methods
Eight
databases
were
searched
from
earliest
records
July
2022.
Studies
investigating
a
intervention
lasting
≥
4
weeks,
including
and/or
health
outcomes,
having
comparison
included.
Screening
data
extraction
performed
by
two
independent
reviewers
at
all
stages.
All
reviewer
disagreements
resolved
primary
author.
Where
appropriate,
meta-analysis
was
performed,
effect
size
estimate
generated.
Results
Of
21,737
identified,
27
studies
met
inclusion
criteria.
Total
sample
included
1392
(944
females,
418
males,
30
unreported).
as
interventions
in
improving
quality
life
people
Parkinson’s
disease
[mean
difference
3.09;
95%
confidence
interval
(CI)
−
2.13
8.30;
p
=
0.25],
reducing
anxiety
(standardised
mean
2.26;
CI
2.37
6.90;
0.34),
depressive
symptoms
0.78;
0.92
2.48;
0.37).
Preliminary
evidence
found
superior
motivation,
aspects
memory,
cognition
reduce
distress.
inferior
stress,
self-efficacy
language
fluency.
Conclusion
Undertaking
any
genre
generally
occasionally
more
than
types
range
Trial
Registration
PROSPERO:
CRD42018099637.
Journal of Medical Internet Research,
Год журнала:
2025,
Номер
27, С. e59195 - e59195
Опубликована: Янв. 10, 2025
Background
Alzheimer
disease
is
incurable,
but
it
possible
to
intervene
and
slow
down
the
progression
of
dementia
during
periods
mild
cognitive
impairment
(MCI)
through
virtual
reality
(VR)
technology.
Objective
This
study
aimed
analyze
effects
VR
interventions
on
older
adults
with
MCI.
The
examined
outcomes
include
abilities,
mood,
quality
life,
physical
fitness,
including
general
function,
memory
performance,
attention
information
processing
speed,
executive
language
proficiency,
visuospatial
depression,
daily
mobility
individuals,
muscle
gait
balance.
Methods
A
total
4
web-based
databases
(Web
Science,
PubMed,
Embase,
Ovid)
were
searched
up
December
30,
2023,
for
randomized
controlled
trials
assessing
self-reported
VR-based
technology
cognition,
fitness
in
(aged
≥55
years)
Two
reviewers
independently
screened
search
results
reference
lists
identified
papers
related
reviews.
Data
intervention
components
delivery
behavioral
change
techniques
used
extracted.
meta-analysis,
risk-of-bias
sensitivity
analysis,
subgroup
analysis
performed
where
appropriate
explore
potential
moderators.
Grading
Recommendations,
Assessment,
Development,
Evaluations
(GRADE)
approach
was
assess
evidence.
Results
review
analyzed
18
studies
involving
722
delivered
different
immersion
levels
training,
or
cognitive-motor
dual-task
training.
showed
significant
improvements
(standardized
mean
difference
[SMD]
0.2,
95%
CI
0.02-0.38),
speed
(SMD
0.25,
0.06-0.45),
function
0.22,
0.02-0.42).
without
therapist
involvement
improved
as
well
speed.
training
also
resulted
MCI
0.31,
0.05-0.58).
In
addition,
immersive
had
a
impact
improving
0.25;
0.01-0.50)
0.00-0.50).
However,
very
small
terms
living
ability,
Quality
evidence
varied,
moderate
ratings
certain
functions
low
others,
based
GRADE
approach.
Conclusions
can
improve
memory,
low,
further
research
needed
confirm
these
findings
additional
health-related
outcomes.
Frontiers in Aging Neuroscience,
Год журнала:
2018,
Номер
10
Опубликована: Май 4, 2018
Prior
research
has
found
that
cognitive
benefits
of
physical
exercise
and
brain
health
in
older
adults
may
be
enhanced
when
mental
is
interactive
simultaneously,
as
exergaming.
It
unclear
whether
the
benefit
can
maximized
by
increasing
degree
challenge
during
exercise.
This
randomized
clinical
trial
(RCT),
Aerobic
Cognitive
Exercise
Study
(ACES)
sought
to
replicate
extend
prior
findings
added
from
exergaming
those
with
or
at
risk
for
mild
impairment
(MCI).
ACES
compares
effects
six
months
an
exer-tour
(virtual
reality
bike
rides)
a
more
effortful
exer-score
(pedaling
through
videogame
score
points).
Fourteen
community-dwelling
meeting
screening
criteria
MCI
(sMCI)
were
adherent
their
assigned
months.
The
primary
outcome
was
executive
function,
while
secondary
outcomes
included
memory
everyday
function.
Exer-tour
yielded
significant
moderate
on
function
(Stroop
A/C;
d's
=
.51
.47);
there
no
interaction
effect.
However,
after
three
revealed
effect,
showed
little
impact,
did
game-only
condition.
Both
conditions
also
resulted
improvements
verbal
memory.
Effects
appear
generalize
self-reported
Pilot
data,
including
salivary
biomarkers
structural
MRI,
gathered
baseline
months;
dose
associated
increased
BDNF
well
grey
matter
volume
PFC
ACC.
Improvement
increase
DLPFC.
Improved
expression
exosomal
miRNA-9.
Interactive
(both
high
low
challenge)
similarly
sMCI
exercisers
over
A
larger
RCT
needed
confirm
these
findings.
Further
innovation
data
are
develop
accessible,
yet
engaging
effective
interventions
combat
decline
growing
population.
A
rapid
increase
in
the
number
of
patients
with
dementia
has
emerged
as
a
global
health
challenge.
Accumulating
evidence
suggests
that
early
diagnosis
and
timely
intervention
can
delay
cognitive
decline.
The
is
commonly
performed
using
neuropsychological
tests,
such
Mini-Mental
State
Examination
(MMSE),
administered
by
trained
examiners.
While
these
traditional
tests
are
valid
reliable,
they
neither
simple
nor
sufficiently
short
routine
screening
tools
for
dementia.
Here,
we
developed
brief
assessment
utilizing
an
eye-tracking
technology.
subject
views
series
(178
s)
task
movies
pictures
displayed
on
monitor
while
their
gaze
points
recorded
device,
scores
determined
from
plots
data.
were
measured
both
eye
tracking-based
80
participants,
including
27
cognitively
healthy
controls
(HC),
26
mild
impairment
(MCI),
correlated
well
showed
good
diagnostic
performance
detecting
MCI
Rapid
technology
enable
quantitative
scoring
sensitive
detection
impairment.
Alzheimer s Research & Therapy,
Год журнала:
2019,
Номер
11(1)
Опубликована: Янв. 5, 2019
Exercise
is
often
proposed
as
a
non-pharmacological
intervention
to
delay
cognitive
decline
in
people
with
dementia,
but
evidence
remains
inconclusive.
Previous
studies
suggest
that
combining
physical
exercise
stimulation
may
be
more
successful
this
respect.
Exergaming
promising
which
combined
cognitively
challenging
tasks
single
session.
The
aim
of
study
was
investigate
the
effect
exergame
training
and
aerobic
on
functioning
older
adults
dementia.
A
three-armed
randomized
controlled
trial
(RCT)
compared
training,
an
active
control
consisting
relaxation
flexibility
exercises.
Individuals
dementia
were
individually
trained
three
times
week
during
12
weeks.
Cognitive
measured
at
baseline,
after
12-week
period
24-week
follow-up
by
neuropsychological
assessment.
domains
executive
function,
episodic
memory,
working
memory
psychomotor
speed
evaluated.
Test
scores
converted
into
standardized
z-scores
averaged
per
domain.
Between-group
differences
analysed
analysis
covariance.
Data
from
115
(mean
(SD)
age
=
79.2
(6.9)
years;
mean
MMSE
score
22.9
(3.4))
analysed.
There
significant
improvement
groups
group
difference
domain
(95%
CI)
versus
0.370
(0.103–0.637),
p
0.007;
0.326
(0.081–0.571),
0.009).
size
moderate
(partial
η2
0.102).
No
between
found
for
functioning,
memory.
To
our
knowledge,
first
RCT
evaluating
effects
We
both
improve
speed,
group.
This
finding
clinically
relevant
important
predictor
functional
decline.
Netherlands
Trial
Register,
NTR5581
.
Registered
7
October
2015.