
Journal of the International AIDS Society, Год журнала: 2024, Номер 28(1)
Опубликована: Дек. 26, 2024
Abstract Introduction WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. Assessments IC may be useful address evolving, non‐HV care needs ageing people HIV (PWH). However, date, its utility within context has not been assessed. Methods Participants included 200 PWH attending out‐patient (2021−2023) in Universiti Malaya Medical Centre, Malaysia 101 community controls aged 35 years above. The ICOPE framework was adapted derive aggregate scores (ranging 0–6) encompassing five domains cognition, sensory (hearing vision), mobility, mood vitality. Multivariable analyses were used explore association multiple health outcomes including frailty, difficulties performing instrumental activities daily living (IADL) inflammatory markers. Area under receiver operator characteristic (AUC‐ROC) calculated predict frailty IADL deficits current cohort an independent 275 from Hong Kong (HK). Results Median (interquartile range, IQR) age among 50 (42−56) (39−59) years, respectively. There more males (83% vs. 56%, p <0.001). All received antiretroviral therapy (ART) a median duration 11 (8−14) years. Aggregate lower but significantly different compared controls, (5.4 5.6, = 0.093) performed worse than only cognitive domain. independently associated (OR 0.17 95% CI 0.07−0.42, <0.001), 0.25 0.14−0.46, <0.001) all other patient‐reported correlated IL‐6 sCD14 sCD163 levels. well identifying (AUC‐ROC ≥ 0.80) HK Malaysian cohorts modestly 0.64) deficits. Conclusions is good composite non‐HIV, physical social vulnerabilities on ART should complement disease‐based monitoring routine care. validated larger, longitudinal diverse settings.
Язык: Английский