European Journal of Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Objective:
Ischemia/reperfusion
(I/R)
injury
is
the
period
of
tissue
or
organ
damage
that
develops
after
tissue's
blood
flow
restored.
The
extent
varies
according
to
severity
and
cell
damage.
Thymoquinone
(TQ)
has
a
wide
therapeutic
spectrum.
effect
thymoquinone
on
melatonin
ferritin
in
I/R
can
regulate
renal
function
by
combining
these
two
mechanisms
improve
Therefore,
levels
as
well
its
regulatory
role
functions
have
been
investigated.
Methods:
Thirty-six
male
Sprague
Dawley
rats
were
included
study
(250-300
g,
8-10
weeks).
randomly
assigned
6
groups
with
animals
each
group.
Groups;
1-
Control,
2-
Sham,
3-
Solvent,
4-
Renal
ischemia/reperfusion
(I/R),
5-
I/R+
(5
mg/kg/day),
6-
TQ
mg/kg/day).
dorsal
region
was
surgically
opened,
left
artery
clamped
for
30
minutes
then
reperfused
24
hours.
(i.p)
applied
treatment
15
days.
At
end
experiment,
samples
taken
from
all
groups,
kidney
tests
(Na+,
K+,
Creatinine,
urea,
BUN)
performed.
Melatonin
analyzed
ELISA
method
samples.
Results:
Data
showed
short-term
effective
serum
K+
(P
=
0.010)
tissue.
iron
activity,
which
normal
healthy
decreased
increased
significantly
positively
regulated
dysregulation
molecules
I/R.
Conclusion:
may
contribute
healing
improving
levels,
indicates
insufficiency
ferritin,
interacting
I/R,
are
TQ,
indicating
they
management
IUBMB Life,
Год журнала:
2024,
Номер
76(12), С. 1011 - 1034
Опубликована: Июль 25, 2024
Abstract
Within
the
last
decade,
scientific
community
has
witnessed
importance
of
ferroptosis
as
a
novel
cascade
molecular
events
leading
to
cellular
decisions
death
distinct
from
apoptosis
and
other
known
forms
cell
death.
Notably,
such
non‐
apoptotic
iron‐dependent
regulated
been
found
be
intricately
linked
several
physiological
processes
well
pathogenesis
various
diseases.
To
this
end,
recent
data
support
notion
that
potential
connection
between
inherited
bone
marrow
failure
(IBMF)
in
individuals
with
ribosomopathies
may
exist.
In
review,
we
suggest
ribosome‐related
IBMFs
identified
mutations
ribosomal
proteins
lead
changes
ribosome
composition
hematopoietic
progenitors,
seem
affect
function,
thus
enhancing
expression
some
mRNAs
subgroups
while
reducing
others.
These
an
imbalance
inside
pathways
are
promoted
others
inhibited.
This
disturbance
is
accompanied
by
ROS
production
lipid
peroxidation,
additional
finding
most
them
iron
accumulation.
Once
peroxidation
accumulation
two
main
characteristics
ferroptosis,
it
possible
mechanism
plays
key
role
manifestation
IBMF
type
disease.
If
further
confirmed,
new
pharmacological
targets
inhibitors
already
exploited
for
treatment
diseases,
could
utilized
improve
ribosomopathies.
European Journal of Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Objective:
Ischemia/reperfusion
(I/R)
injury
is
the
period
of
tissue
or
organ
damage
that
develops
after
tissue's
blood
flow
restored.
The
extent
varies
according
to
severity
and
cell
damage.
Thymoquinone
(TQ)
has
a
wide
therapeutic
spectrum.
effect
thymoquinone
on
melatonin
ferritin
in
I/R
can
regulate
renal
function
by
combining
these
two
mechanisms
improve
Therefore,
levels
as
well
its
regulatory
role
functions
have
been
investigated.
Methods:
Thirty-six
male
Sprague
Dawley
rats
were
included
study
(250-300
g,
8-10
weeks).
randomly
assigned
6
groups
with
animals
each
group.
Groups;
1-
Control,
2-
Sham,
3-
Solvent,
4-
Renal
ischemia/reperfusion
(I/R),
5-
I/R+
(5
mg/kg/day),
6-
TQ
mg/kg/day).
dorsal
region
was
surgically
opened,
left
artery
clamped
for
30
minutes
then
reperfused
24
hours.
(i.p)
applied
treatment
15
days.
At
end
experiment,
samples
taken
from
all
groups,
kidney
tests
(Na+,
K+,
Creatinine,
urea,
BUN)
performed.
Melatonin
analyzed
ELISA
method
samples.
Results:
Data
showed
short-term
effective
serum
K+
(P
=
0.010)
tissue.
iron
activity,
which
normal
healthy
decreased
increased
significantly
positively
regulated
dysregulation
molecules
I/R.
Conclusion:
may
contribute
healing
improving
levels,
indicates
insufficiency
ferritin,
interacting
I/R,
are
TQ,
indicating
they
management
