Transcranial
Photobiomodulation
(tPBM)
offers
significant
potential
for
cognitive
enhancement
and
therapy.
A
critical
gap
remains
in
our
understanding
of
the
differential
impacts
pulsed
versus
continuous
tPBM
on
human
electroencephalogram
(EEG)
patterns.
Treatment
planners
do
not
have
objective
metrics
to
ascertain
optimal
dosage
parameters
which
hampers
development
effective
closed-loop
neuromodulation
systems.
This
study
focuses
key
EEG
markers:
interhemispheric
coherence
frequency
entrainment.
Concurrent
recordings
were
conducted
healthy
participants
single
sessions
with
continuous,
modular
protocols.
Putative
indicators
protocols
are
hypothesized
be
post-intervention
increases
relative
alpha
power
normalization.
The
quantifies
changes
from
baseline
demonstrate
dosimetry
effects.
We
anticipate
that
will
elucidate
distinct
effects
protocols,
an
expected
normalization
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 23, 2024
This
manuscript
outlines
a
model
of
Alzheimer’s
Disease
(AD)
pathophysiology
in
progressive
layers,
from
its
genesis
to
the
development
biomarkers
and
then
symptom
expression.
Genetic
predispositions
are
major
factor
that
leads
mitochondrial
dysfunction
subsequent
amyloid
tau
protein
accumulation,
which
have
been
identified
as
hallmarks
AD.
Extending
beyond
these
accumulations,
we
explore
broader
spectrum
pathophysiological
aspects,
including
blood–brain
barrier,
blood
flow,
vascular
health,
gut-brain
microbiodata,
glymphatic
metabolic
syndrome,
energy
deficit,
oxidative
stress,
calcium
overload,
inflammation,
neuronal
synaptic
loss,
brain
matter
atrophy,
reduced
growth
factors.
Photobiomodulation
(PBM),
delivers
near-infrared
light
selected
regions
using
portable
devices,
is
introduced
therapeutic
approach.
PBM
has
potential
address
each
with
data
provided
by
various
studies.
They
provide
mechanistic
support
for
largely
small
published
clinical
studies
demonstrate
improvements
memory
cognition.
inform
PBM’s
treat
AD
pending
validation
large
randomized
controlled
The
presentation
network
waveform
changes
on
electroencephalography
(EEG)
opportunity
use
guide
application
parameters
improve
outcomes.
These
include
wavelength,
power
density,
treatment
duration,
LED
positioning,
pulse
frequency.
Pulsing
at
specific
frequencies
found
influence
expression
waveforms
modifications
networks.
stems
modulation
cellular
structures
revealed
recent
findings
an
EEG-based
artificial
intelligence
personalize
through
EEG
feedback.
Biomedicines,
Год журнала:
2024,
Номер
12(5), С. 1116 - 1116
Опубликована: Май 17, 2024
Background:
Recent
evidence
has
identified
great
promise
for
the
novel
whole-body
photobiomodulation
therapy
(PBMT)
individuals
with
fibromyalgia
(FM).
However,
currently
no
documented
experiences
of
participants.
The
objective
this
study
was
to
qualitatively
assess
treatment
experience
and
response
in
a
group
participants
FM
undergoing
course
PBMT.
Methods:
An
interpretive
hermeneutic
phenomenological
situated
within
worldview
pragmatism
undertaken.
A
convenience
sample
were
included
if
they
had
undertaken
6-week
trial
Individuals
undertook
semi-structured
interviews
exploring
multidimensional
responses
during
Week
3
6.
Results:
Sixteen
(47.3
±
10.9
years)
took
part
study.
analysis
produced
three
overarching
themes
that
previously
from
baseline
(namely,
‘Body
Structure
&
Function’,
‘Activities
Participation’,
‘Environment’)
an
additional
five
sub-themes
highlighted
intervention
experience.
Subsequently,
four
important
processes
observed
identified:
increased
motivation;
feeling
proud;
improved
confidence;
like
‘old
self’.
This
ultimately
culminated
identification
positive
spiral,
which
we
have
termed
‘recomposition’.
Conclusions:
We
believe
our
is
first
field
chronic
pain
management
utilise
qualitative
methodology
directly
acceptability
efficacy
specific
medical
clinical
trial,
PBMT
findings
are
compelling
warrant
further
work
support
introduction
device
into
National
Health
Service
(NHS).
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 17, 2024
Introduction
Transcranial
photobiomodulation
(tPBM)
is
a
non-invasive
neuromodulation
technology
which
has
become
promising
therapy
for
treating
many
brain
diseases.
Although
it
been
confirmed
in
studies
targeting
neurological
diseases
including
Alzheimer’s
and
Parkinson’s
that
tPBM
can
improve
cognitive
function,
the
effectiveness
of
interventions
TBI
patients
remains
to
be
determined.
This
systematic
review
examines
outcomes
clinical
trials
concerning
treatment
traumatic
injury
(TBI).
Methods
We
conducted
literature
review,
following
PRISMA
guidelines.
The
PubMed,
Web
Science,
Scopus,
EMBASE,
Cochrane
Library
databases
were
searched
before
October
31,
2023.
Results
initial
search
retrieved
131
articles,
total
6
finally
included
full
text-analysis
after
applying
inclusion
exclusion
criteria.
Conclusion
showed
improvements
cognition
with
chronic
intervention.
mechanism
may
increases
volume
cortical
gray
matter
(GM),
subcortical
GM,
thalamic,
improves
cerebral
blood
flow
(CBF),
functional
connectivity
(FC),
oxygenation,
improving
function.
However,
due
significant
heterogeneity
application,
we
cannot
summarize
optimal
parameters
TBI.
In
addition,
there
currently
lack
RCT
this
field.
Therefore,
given
encouraging
but
uncertain
finding,
necessary
conduct
randomized
controlled
further
determine
role
rehabilitation
patients.
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
101(1), С. 321 - 335
Опубликована: Авг. 17, 2024
Background:
Alzheimer’s
disease
has
become
increasingly
prevalent
among
the
older
population,
leading
to
significant
social
and
economic
burdens.
Transcranial
photobiomodulation
(tPBM)
shown
promise
as
a
cognitive
intervention
for
enhancing
efficiency
in
healthy
adults,
individuals
with
mild
impairment
disease.
However,
determining
optimal
tPBM
dosage
is
crucial
ensuring
effective
efficient
intervention.
Objective:
This
study
aimed
compare
effects
of
different
dosages
single
session
on
adults.
Methods:
In
this
randomized
controlled
trial,
88
participants
were
assigned
either
dose
(irradiance
=
30
mW/cm
2
,
fluence
10.8
J/cm
;
n
44)
or
double
21.6
session.
Cognitive
was
assessed
using
functional
near-infrared
spectroscopy
during
visual
working
memory
span
task.
Results:
The
group
exhibited
significantly
greater
enhancement,
indicated
by
more
pronounced
reduction
oxygenated
hemoglobin
challenging
task
level
(span
9)
(
p
0.021,
d
0.50),
better
performance
0.045,
0.31).
Furthermore,
visuospatial
abilities
demonstrated
improvement
after
r
–0.42,
0.004).
contrast,
varying
function
did
not
exhibit
additional
benefits
from
–0.22–0.15,
0.16–0.95).
Conclusions:
These
findings
suggest
that
higher
may
necessarily
result
superior
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(12)
Опубликована: Дек. 1, 2024
ABSTRACT
Photobiomodulation
(PBM),
also
known
as
low‐level
laser
therapy,
employs
red
or
near‐infrared
light
emitted
from
a
light‐emitting
diode
for
the
treatment
of
various
conditions.
Transcranial
PBM
(tPBM)
is
form
that
delivered
to
head
improve
brain
health,
tPBM
enhances
mitochondrial
function,
improves
antioxidant
responses,
reduces
inflammation,
offers
protection
apoptosis,
blood
flow,
increases
cellular
energy
production,
and
promotes
neurogenesis
neuroplasticity.
As
such,
holds
promise
stroke.
This
review
summarizes
recent
findings
on
stroke,
presenting
evidence
both
animal
studies
clinical
trials
demonstrate
its
efficacy.
Additionally,
it
discusses
potential
challenges
encountered
in
translation
process.
Furthermore,
proposes
new
technologies
directions
development
light‐delivery
methods
emphasizes
need
extensive
validate
widen
application
future
treatments
