Transcranial
Photobiomodulation
(tPBM)
offers
significant
potential
for
cognitive
enhancement
and
therapy.
A
critical
gap
remains
in
our
understanding
of
the
differential
impacts
pulsed
versus
continuous
tPBM
on
human
electroencephalogram
(EEG)
patterns.
Treatment
planners
do
not
have
objective
metrics
to
ascertain
optimal
dosage
parameters
which
hampers
development
effective
closed-loop
neuromodulation
systems.
This
study
focuses
key
EEG
markers:
interhemispheric
coherence
frequency
entrainment.
Concurrent
recordings
were
conducted
healthy
participants
single
sessions
with
continuous,
modular
protocols.
Putative
indicators
protocols
are
hypothesized
be
post-intervention
increases
relative
alpha
power
normalization.
The
quantifies
changes
from
baseline
demonstrate
dosimetry
effects.
We
anticipate
that
will
elucidate
distinct
effects
protocols,
an
expected
normalization
Brazilian Journal of Science,
Год журнала:
2023,
Номер
3(1), С. 140 - 158
Опубликована: Авг. 25, 2023
Autism
Spectrum
Disorder
constitutes
a
complex,
elaborate,
and
diverse
condition
at
developmental,
biological,
neurophysiological
level.
It
is
recognized
primarily
by
the
behavioral
manifestations
of
individual
in
communication,
social
interaction,
extension
his
cognitive
development
adaptation
to
society
as
whole.
A
wide
range
studies
have
linked
pathophysiology
autism
dysfunctional
elements
function
mitochondria,
cells,
neurons,
gastrointestinal
microbiome.
Low
Light
Laser
Therapy
(LLLT)
an
innovative,
emerging,
non-invasive
treatment
method.
utilizes
low
levels
red
light/near-infrared
light
positively
affecting
biological
pathological
processes
body
enhancing
cellular,
mitochondrial
stimulation,
neurogenesis,
synaptogenesis,
immune
system
development,
regulating
gut
microbiome's
function.
The
retrospective
literature
review
focuses
on
possibility
effective
use
method
autism.
According
literature,
LLLT
does
not
many
applications
patients
with
ASD
still
early
stages
its
disorder.
However,
results
highlight
therapeutic
effect
several
areas
related
disease,
pointing
out
that
it
promising
approach
for
evolution
future.
Creativity Research Journal,
Год журнала:
2023,
Номер
36(1), С. 1 - 14
Опубликована: Июнь 11, 2023
ABSTRACTABSTRACTTranscranial
photobiomodulation
(tPBM)
has
been
used
for
cognitive
enhancement
in
healthy
people.
However,
its
effect
on
creativity
not
investigated.
The
default
mode
network
(DMN)
is
associated
with
divergent
thinking
(DT;
but
convergent
thinking,
CT),
and
also
anxiety,
which
turn
negatively
related
to
creativity.
We
aimed
use
tPBM
over
the
DMN
assess
DT
compared
sham.
Additionally,
we
assessed
possible
mediating
of
anxiety
between
DT.
In
this
single-blind,
between-subjects
study,
58
participants
were
randomly
assigned
or
sham
group.
was
applied
using
near-infrared
light
(810
nm,
40
Hz;
50%
duty
cycle),
through
light-emitting
diode
devices
combining
transcranial
plus
intranasal
PBM
cortical
nodes
20
min
(240
J/cm2
total).
CT
before
(baseline)
after
Unusual
Uses
(UU),
Picture
Completion
(PC)
Remote
Associates
test
(RAT).
ANCOVA
(post-stimulation
controlling
baseline)
results
showed
that
group
had
significantly
higher
scores
total
UU,
PC,
may
be
effective
enhancement.
lack
reveals
a
specific
link
DT.Keywords:
Transcranial
photobiomodulationcreativitydefault
networkdivergent
AcknowledgmentsWe
would
like
thank
all
their
time
efforts
participating
study.Disclosure
statementNo
potential
conflict
interest
reported
by
authors.Data
availability
statementThe
data
support
findings
study
are
available
from
corresponding
author,
[JP],
upon
reasonable
request.Additional
informationFundingThis
supported
Department
Education
Science
Basque
Government
[IT946‐16].
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
Abstract
This
study
investigated
the
causal
effect
of
transcranial
photobiomodulation
(tPBM)
over
left
prefrontal
cortex
(LPFC)
on
syntactically
complex
Mandarin
Chinese
first
language
(L1)
and
second
(L2)
sentence
processing
performances.
Two
(L1
L2)
groups
participants
(thirty
per
group)
were
recruited
to
receive
double-blind,
sham-controlled
tPBM
intervention,
followed
by
processing,
verbal
working
memory
(WM),
visual
WM
tasks.
Results
revealed
a
consistent
pattern
for
both
groups:
(a)
enhanced
performance
but
not
performance;
(b)
Participants
with
lower
performances
under
sham
benefited
more
from
active
tPBM.
Taken
together,
current
substantiated
that
L1
L2
ability
directly
without
interference,
would
serve
as
promising
cost-effective
noninvasive
brain
stimulation
(NIBS)
tool
future
applications
upregulating
human
faculty.
Highlights
The
applies
(complex)
processing.
enhances
in
&
speakers.
interference
WM.
A
role
LPFC
through
Opening
up
application
prospect
Transcranial
Photobiomodulation
(tPBM)
offers
significant
potential
for
cognitive
enhancement
and
therapy.
A
critical
gap
remains
in
our
understanding
of
the
differential
impacts
pulsed
versus
continuous
tPBM
on
human
electroencephalogram
(EEG)
patterns.
Treatment
planners
do
not
have
objective
metrics
to
ascertain
optimal
dosage
parameters
which
hampers
development
effective
closed-loop
neuromodulation
systems.
This
study
focuses
key
EEG
markers:
interhemispheric
coherence
frequency
entrainment.
Concurrent
recordings
were
conducted
healthy
participants
single
sessions
with
continuous,
modular
protocols.
Putative
indicators
protocols
are
hypothesized
be
post-intervention
increases
relative
alpha
power
normalization.
The
quantifies
changes
from
baseline
demonstrate
dosimetry
effects.
We
anticipate
that
will
elucidate
distinct
effects
protocols,
an
expected
normalization
