Melatonin and Cytokines Modulate Daily Instrumental Activities of Elderly People with SARS-CoV-2 Infection

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 8647 - 8647

Опубликована: Май 12, 2023

The Comprehensive Geriatric Assessment analyzes the health and quality of life elderly. Basic instrumental daily activities may be compromised due to neuroimmunoendocrine changes, studies suggest that possible immunological changes occur during infections in Thus, this study aimed analyze cytokine melatonin levels serum correlate elderly patients with SARS-CoV-2 infection. sample consisted 73 individuals, 43 whom were without infection 30 had positive diagnoses COVID-19. Blood samples collected quantify cytokines by flow cytometry ELISA. In addition, structured validated questionnaires applied assess basic (Katz) (Lawton Brody) activities. There was an increase IL-6, IL-17, group individuals a correlation observed between IL-6 IL-17 Furthermore, there reduction score Lawton Brody Scale infected These data hormone inflammatory are altered is degree dependence, mainly regarding performance activities, considerable impact on person's ability perform everyday tasks necessary for independent living extremely important result, probably associated alterations these

Язык: Английский

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Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients Using Machine Learning and Immune Cell Infiltration Analysis

Biochemical Genetics, Год журнала: 2024, Номер unknown

Опубликована: Апрель 24, 2024

Язык: Английский

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Impact of the COVID-19 pandemic and vaccination on global, regional, and national burden of Guillain-Barre syndrome: observational study

Опубликована: Июль 10, 2024

Abstract Objectives To estimate the global, regional, and national burden trends of Guillain-Barré Syndrome (GBS), to explore impact COVID-19 pandemic related public health measures on GBS burden. Design Observational study. Setting 204 countries territories. Data sources Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021 Our World in Data. Main outcome All-cause COVID-19-specific age-standardized years lived with disability (YLD) rates estimated annual percentage change (EAPC). Results Globally, significantly increased during pandemic, YLD were 0.86 (95% uncertainty interval (UI): 0.56 1.24) per 100,000 people 2020, rising 1.75 UI: 1.12 2.54) 2021, reflecting an EAPC 70.35% 38.73 109.06) from 2019 2021. Regionally, highest 2020 observed high-income Asia Pacific central Latin America, respectively, while lowest found East for both years. Age-standardized rose 3.7 times faster a low socio-demographic index (SDI) versus high SDI (103.21% year 71.10 141.35%) vs 28.02% (11.46 47.03)). Males generally had higher across all age groups, disparity those aged 80 above. During first two increase was more pronounced females younger populations 15-29 A statistically negative correlation between vaccination coverage burden, increases full 100 leading decreases all-cause by 0.0070 0.0128 people. Conclusion Predominantly driven surge cases, especially lower levels. Greater (15-29 years). Importantly, benefits outweighed risks controlling post-COVID-19 although significant disparities existed countries. These findings offer robust evidence facilitating education transparent communication highlight urgency targeted control manage post-infection complications, such as GBS, future waves or other potential pandemics. WHAT IS ALREADY KNOWN ON THIS TOPIC syndrome (GBS) is autoimmune disease, respiratory gastrointestinal infections are major triggering factors. From 1990 2019, relatively low, negligible changes most The remains not fully understood. STUDY ADDS global 70.30% annually, regions experienced rapid increment (103.21%). severe acute coronavirus 2 (SARS-CoV-2) infection primary factor contributing pandemic. Improving effective measure reduce each additional vaccinated person (per hundred people) decreased population.

Язык: Английский

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Impact of Baseline Patient Characteristics on Short- and Long-Term Overall Mortality in Elderly Patients with COVID-19: A Retrospective Cohort Study

Geriatrik Bilimler Dergisi, Год журнала: 2024, Номер 7(2), С. 83 - 92

Опубликована: Авг. 29, 2024

Aim: Elderly people encounter COVID-19 more frequently due to physiological changes associated with aging and underlying potential health conditions.The study aims evaluate the impact of baseline patient characteristics on short- long-term mortality in elderly patients aged 65 over, classified as youngest-old, middle-aged, or oldest-old, who applied pandemic outpatient clinic had not yet been vaccinated. Materials Methods: Symptomatic attended emergency department were enrolled study. Demographic data, symptoms, comorbidities, thoracic computed tomography (CT), laboratory results recorded at admission. The primary outcomes all-cause short-term (within six months) four years) mortality. Results: consists 393 participants, a mean age 67.4 ± 9.8 years 52.2% male. Considering death rates last years, it was determined that 72 (18.3%) cases died short term, 104 (26.5%) long term. It found chronic renal failure (CRF), coronary artery disease (CAD), middle-old oldest-old-aged compared 50-64 group independent predictors overall following factors independently predicted mortality: male gender, CAD, malignancy, CRF, fever, dyspnea middle-old, oldest-old relative 50–64 group. Conclusion: Advanced age, symptoms shortness breath high D-dimer levels, presence CRF related higher risk from infection elderly.

Язык: Английский

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Critical care in older adults: Research landscape and hotspots from a bibliometric perspective

Medicine, Год журнала: 2024, Номер 103(38), С. e39754 - e39754

Опубликована: Сен. 20, 2024

As the population ages, there will be an increasing demand for health care resources, particularly in intensive care. Therefore, critically ill older adults are receiving attention and have been extensively studied. However, research landscape, dynamic patterns, emerging topics this area scarcely reviewed. This study aimed to delve into current status trends (publication volume topics) critical (including interventions, outcomes, complications) using bibliometric analysis. We retrieved original articles reviews focusing on published between 2013 2022 from Web of Science core database. To examine present trends, we employed VOSviewer CiteSpace software analysis visualization. The cooperative network countries institutions, cocited authorship network, references, cooccurrence keywords were analyzed. Overall, 6356 analyzed, revealing a noticeable upward trend number publications focused adults. In total, 34,654 authors 7989 institutions across 131 collaborated publish papers related 1715 academic journals. United States America China top contributors terms studies, while Bertrand Guidet was most prolific author with highest articles. A dual-map overlay literature revealed that Molecular/Biology/Genetics Health/Nursing/Medicine journals frequently referenced Medicine/Medical/Clinical Older patients coronavirus disease 2019, delirium, frailty new developing areas interest. is first indicate comprehensive geriatric assessment, tailored specific therapeutic algorithms among recommended improve outcomes. Furthermore, provides valuable insights clinical decision-making, guideline development, resource allocation settings.

Язык: Английский

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