Biomedicines,
Год журнала:
2023,
Номер
11(10), С. 2711 - 2711
Опубликована: Окт. 5, 2023
Nonalcoholic
fatty
liver
disease
(NAFLD),
recently
redefined
as
metabolic-dysfunction-associated
(MASLD),
is
liver-metabolism-associated
steatohepatitis
caused
by
nonalcoholic
factors.
NAFLD/MASLD
currently
the
most
prevalent
in
world,
affecting
one-fourth
of
global
population,
and
its
prevalence
increases
with
age.
Current
treatments
are
limited;
one
important
reason
hindering
drug
development
insufficient
understanding
onset
pathogenesis
NAFLD/MASLD.
C-reactive
protein
(CRP),
a
marker
inflammation,
has
been
linked
to
NAFLD
aging
recent
studies.
As
conserved
acute-phase
protein,
CRP
widely
characterized
for
host
defense
functions,
but
link
between
remains
unclear.
Herein,
we
discuss
available
evidence
involvement
MASLD
identify
areas
where
further
research
needed.
We
hope
this
review
can
provide
new
insights
into
aging-associated
biomarkers
suggest
that
modulation
signaling
potential
therapeutic
target.
Cancers,
Год журнала:
2023,
Номер
15(18), С. 4566 - 4566
Опубликована: Сен. 14, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
or
metabolic
dysfunction-associated
steatotic
(MASLD)
and
steatohepatitis
(NASH)
are
chronic
hepatic
conditions
leading
to
hepatocellular
carcinoma
(HCC)
development.
According
the
recent
“multiple-parallel-hits
hypothesis”,
NASH
could
be
caused
by
abnormal
metabolism,
accumulation
of
lipids,
mitochondrial
dysfunction,
oxidative
endoplasmic
reticulum
stresses
is
found
in
obese
non-obese
patients.
Recent
translational
research
studies
have
discovered
new
proteins
signaling
pathways
that
involved
not
only
development
NAFLD
but
also
its
progression
NASH,
cirrhosis,
HCC.
Nevertheless,
mechanisms
HCC
developing
from
precancerous
lesions
yet
been
fully
elucidated.
Now,
it
particular
importance
start
focusing
on
discovery
novel
molecular
mediate
alterations
glucose
lipid
which
leads
steatosis.
The
role
mTOR
has
recently
attracted
attention.
goals
this
review
(1)
highlight
genetic
protein
contributions
NAFLD/NASH;
(2)
investigate
how
scientific
findings
might
outline
process
causes
NASH-associated
HCC;
(3)
explore
reliable
biomarkers/targets
NAFLD/NASH-associated
hepatocarcinogenesis.
Egyptian Liver Journal,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 12, 2024
Abstract
Background
Polyploidization,
a
process
where
cells
acquire
additional
chromosome
sets,
is
unique
characteristic
of
hepatocytes.
This
has
been
increasingly
recognized
as
an
adaptive
mechanism
for
maintaining
liver
function
during
aging,
period
characterized
by
cellular
senescence,
DNA
damage,
and
metabolic
dysregulation.
Purpose
review
explores
the
molecular
mechanisms
underlying
hepatocyte
polyploidization
its
potential
role
in
promoting
resilience
against
aging-related
decline
function.
We
assess
how
polyploid
hepatocytes
contribute
to
genomic
stability,
stress
resistance,
adaptation,
highlighting
their
relevance
aging.
Main
body
Hepatocyte
occurs
through
such
cytokinesis
failure
endoreplication,
leading
binuclear
or
mononuclear
cells.
Polyploid
exhibit
enhanced
repair
capacity,
which
helps
mitigate
accumulation
age-related
damage.
The
increased
gene
dosage
facilitates
better
responses,
particularly
oxidative
genotoxic
insults.
Metabolic
adaptations,
including
xenobiotic
metabolism
lipid
regulation,
further
support
liver’s
ability
maintain
homeostasis
Additionally,
demonstrate
altered
epigenetic
landscapes
proteostasis
mechanisms,
contributing
improved
reduced
susceptibility
senescence.
These
adaptations
collectively
enhance
structural
challenges.
Conclusion
represents
critical
protective
that
safeguard
instability,
dysfunction,
stress.
Understanding
pathways
driving
could
pave
way
novel
therapeutic
strategies
combat
disorders
health
span.
Graphical
Biomedicines,
Год журнала:
2023,
Номер
11(10), С. 2711 - 2711
Опубликована: Окт. 5, 2023
Nonalcoholic
fatty
liver
disease
(NAFLD),
recently
redefined
as
metabolic-dysfunction-associated
(MASLD),
is
liver-metabolism-associated
steatohepatitis
caused
by
nonalcoholic
factors.
NAFLD/MASLD
currently
the
most
prevalent
in
world,
affecting
one-fourth
of
global
population,
and
its
prevalence
increases
with
age.
Current
treatments
are
limited;
one
important
reason
hindering
drug
development
insufficient
understanding
onset
pathogenesis
NAFLD/MASLD.
C-reactive
protein
(CRP),
a
marker
inflammation,
has
been
linked
to
NAFLD
aging
recent
studies.
As
conserved
acute-phase
protein,
CRP
widely
characterized
for
host
defense
functions,
but
link
between
remains
unclear.
Herein,
we
discuss
available
evidence
involvement
MASLD
identify
areas
where
further
research
needed.
We
hope
this
review
can
provide
new
insights
into
aging-associated
biomarkers
suggest
that
modulation
signaling
potential
therapeutic
target.
