The
present
white
paper
concerns
the
indications
and
recommendations
of
SciSpacE
Science
Community
to
make
progress
in
filling
gaps
knowledge
that
prevent
us
from
answering
question:
"How
Do
Gravity
Alterations
Affect
Animal
Human
Systems
at
a
Cellular/Tissue
Level?"
This
is
one
five
major
scientific
issues
ESA
roadmap
"Biology
Space
Analogue
Environments".
Despite
many
studies
conducted
so
far
on
spaceflight
adaptation
mechanisms
related
pathophysiological
alterations
observed
astronauts,
we
are
not
yet
able
elaborate
synthetic
integrated
model
changes
occurring
different
system
functional
levels.
Consequently,
it
difficult
develop
credible
models
for
predicting
long-term
consequences
human
space
environment,
as
well
implement
medical
support
plans
missions
strategy
preventing
possible
health
risks
due
prolonged
exposure
beyond
low
Earth
orbit
(LEO).
research
activities
suggested
by
community
have
aim
overcome
these
problems
striving
connect
biological
physiological
aspects
more
holistic
view
effects.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 926 - 926
Опубликована: Янв. 11, 2024
Cancer
is
defined
as
a
group
of
diseases
characterized
by
abnormal
cell
growth,
expansion,
and
progression
with
metastasis.
Various
signaling
pathways
are
involved
in
its
development.
Malignant
tumors
exhibit
high
morbidity
mortality.
research
increased
our
knowledge
about
some
the
underlying
mechanisms,
but
to
this
day,
understanding
disease
unclear.
High
throughput
omics
technology
bioinformatics
were
successful
detecting
unknown
cancer
mechanisms.
However,
novel
groundbreaking
ideas
necessary.
A
stay
orbit
causes
biochemical
molecular
biological
changes
human
cells
which
first,
above
all,
due
microgravity
(µg).
The
µg-environment
provides
conditions
that
not
reachable
on
Earth,
allow
researchers
focus
controlling
growth
space
already
demonstrated
how
cell-exposure
µg
influenced
several
processes
being
cancer.
This
approach
has
potential
fight
develop
future
strategies.
Space
been
shown
impact
like
proliferation,
apoptosis,
survival,
adhesion,
migration,
cytoskeleton,
extracellular
matrix,
focal
factors,
among
others.
concise
review
focuses
publications
related
genetic,
transcriptional,
epigenetic,
proteomic,
metabolomic
studies
tumor
exposed
real
or
simulated
using
simulation
devices.
We
discuss
all
investigating
different
types
from
brain
hematological
system,
sarcomas,
well
thyroid,
prostate,
breast,
gynecologic,
gastrointestinal,
lung
cancers,
order
gain
new
innovative
for
basic
biology
Astrobiology,
Год журнала:
2024,
Номер
24(1), С. 100 - 113
Опубликована: Янв. 1, 2024
The
health
of
astronauts
during
space
travel
to
new
celestial
bodies
in
the
Solar
System
is
a
critical
factor
planning
mission.
Despite
cleaning
and
decontamination
protocols,
microorganisms
from
Earth
have
been
will
be
identified
on
spacecraft.
This
raises
concerns
for
human
safety
planetary
protection,
especially
if
these
can
evolve
adapt
environment.
In
this
study,
we
examined
tolerance
clinically
relevant
nonfastidious
bacterial
species
that
originate
environmental
sources
(Burkholderia
cepacia,
Klebsiella
pneumoniae,
Pseudomonas
aeruginosa,
Serratia
marcescens)
simulated
martian
conditions.
Our
research
showed
changes
growth
survival
presence
perchlorates,
under
desiccating
conditions,
exposure
ultraviolet
radiation,
atmospheric
composition
pressure.
addition,
our
results
demonstrate
was
enhanced
by
addition
regolith
simulant
media.
Additional
future
warranted
examine
potential
infectivity,
pathogenicity,
virulence
with
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 11, 2024
Human
space
exploration
poses
inherent
risks
to
astronauts'
health,
leading
molecular
changes
that
can
significantly
impact
their
well-being.
These
alterations
encompass
genomic
instability,
mitochondrial
dysfunction,
increased
inflammation,
homeostatic
dysregulation,
and
various
epigenomic
changes.
Remarkably,
these
bear
similarities
those
observed
during
the
aging
process
on
Earth.
However,
our
understanding
of
connection
between
shifts
disease
development
in
remains
limited.
Frailty
syndrome,
a
clinical
syndrome
associated
with
biological
aging,
has
not
been
comprehensively
investigated
spaceflight.
To
bridge
this
knowledge
gap,
we
leveraged
murine
data
obtained
from
NASA's
GeneLab,
along
astronaut
gathered
JAXA
Inspiration4
missions.
Our
objective
was
assess
presence
markers
pathways
related
frailty,
sarcopenia
within
spaceflight
context.
Through
analysis,
identified
notable
gene
expression
patterns
may
be
indicative
frailty-like
condition
findings
suggest
parallels
extend
frailty
as
well.
Consequently,
further
investigations
exploring
utility
index
monitoring
health
appear
warranted.
Microphysiological
systems
provide
the
opportunity
to
model
accelerated
changes
at
human
tissue
level
in
extreme
space
environment.
Spaceflight-induced
muscle
atrophy
experienced
by
astronauts
shares
similar
physiological
wasting
older
adults,
known
as
sarcopenia.
These
shared
attributes
a
rationale
for
investigating
molecular
cells
exposed
spaceflight
that
may
mimic
underlying
pathophysiology
of
We
report
results
from
three-dimensional
myobundles
derived
biopsies
young
and
integrated
into
an
autonomous
CubeLab™,
flown
International
Space
Station
(ISS)
aboard
SpaceX
CRS-21
part
NIH/NASA
funded
Tissue
Chips
program.
Global
transcriptomic
RNA-Seq
analyses
comparing
on
ground
revealed
downregulation
transcripts
related
myoblast
proliferation
differentiation.
The
also
downregulated
differentially
expressed
gene
pathways
metabolism
unique
cohort
environment
compared
controls.
Gene
classes
inflammatory
were
flight
samples
cultured
younger
Our
chip
platform
provides
approach
studying
cell
effects
biology
not
be
appreciated
whole
organ
or
organism
sets
stage
continued
data
collection
experimentation
microgravity.
challenges
opportunities
conducting
tissue-on-chip
CubeLabTM
payloads
ISS.
Ageing Research Reviews,
Год журнала:
2024,
Номер
95, С. 102227 - 102227
Опубликована: Фев. 10, 2024
Astronauts
returning
from
space
missions
often
exhibit
health
issues
mirroring
age-related
conditions,
suggesting
spaceflight
as
a
potential
driver
of
biological
ageing
and
diseases.
To
unravel
the
underlying
mechanisms
these
this
comprehensive
review
explores
impact
"exposome"
on
twelve
hallmarks
ageing.
Through
meticulous
analysis
encompassing
both
environments
terrestrial
analogs,
we
aim
to
decipher
how
different
conditions
influence
hallmarks.
Utilizing
PubMed,
identified
189
studies
60
meet
screening
criteria.
Research
in
has
focused
genomic
instability,
chronic
inflammation,
deregulated
nutrient
sensing.
Spaceflight
consistently
induces
linked
prolonged
exposure
ionizing
radiation,
triggers
pro-inflammatory
immune
alterations,
resembling
isolated
simulations.
Nutrient
sensing
pathways
reveal
increased
systemic
insulin-like
growth-factor-
1.
Microbiome
indicate
imbalances
favoring
opportunistic
species
during
spaceflight.
Telomere
dynamics
present
intriguing
patterns,
with
lengthening
rapid
shortening
upon
return.
Despite
pro-ageing
trend,
some
protective
emerge.
Countermeasures,
dietary
adjustments,
prebiotics,
postbiotics,
symbiotics,
tailored
exercises,
meditation,
anti-inflammatory
supplements,
potential.
Spaceflight's
is
intricate,
diverse
findings
challenging
established
beliefs.
Multidisciplinary
provide
guidance
for
future
research
field.
Abstract
As
the
space
industry
grows
exponentially
and
aspirations
for
travel
expand,
we
are
entering
a
new
era
where
will
very
likely
become
an
interplanetary
species.
Although
reproduction
is
essential
human
function
necessary
species
survival,
have
remarkably
little
knowledge
regarding
impact
of
on
female
reproductive
system.
The
effects
spaceflight
potential,
fertility,
implantation
subsequent
pregnancy
resulting
in
healthy
live
birth
must
be
considered
before
planning
prolonged
missions
colonization
planets.
In
this
review,
explore
what
known
remains
to
learned
about
endocrinology.
We
also
delve
deeper
into
endocrinology
discuss
normal
physiologic
mechanisms
at
molecular
level
better
understanding
how
it
may
change
during
spaceflight.
rigors
including
radiation,
gravitational
stressors,
circadian
rhythm
changes
could
potentially
affect
ovulation,
fertilization,
endometrial
receptivity,
preimplantation
embryo
development,
implantation,
placentation,
pregnancy.
Thus,
examine
hypothalamic–pituitary–gonadal
(HPG)
axis,
ovarian
folliculogenesis
steroidogenesis,
early
embryogenesis,
further
recent
advances
future
research
platforms.
Establishing
effect
health,
as
well
developing
countermeasures
mitigate
adverse
effects,
decisive
components
our
species’
successful
transition
one.
Mechanisms of Ageing and Development,
Год журнала:
2025,
Номер
unknown, С. 112028 - 112028
Опубликована: Янв. 1, 2025
The
Linker
of
Nucleoskeleton
and
Cytoskeleton
(LINC)
complex
plays
a
crucial
role
in
connecting
the
nuclear
envelope
to
cytoskeleton,
providing
structural
support
nucleus
facilitating
mechanical
signaling
between
extracellular
environment
nucleus.
Research
mechanobiology
onboard
International
Space
Station
(ISS)
simulated
microgravity
(SMG)
highlight
importance
gravity
functional
mechanotransduction.
Although
altered
research
regarding
has
been
greatly
focused
on
cytoskeleton
matrix
(ECM),
recent
demonstrates
that
SMG
also
induces
changes
mechanics
gene
expression
patterns,
which
have
shown
be
LINC
dependent.
Additionally,
dysregulation
disrupts
integrity
leads
shape
abnormalities
both
Hutchinson-Gilford
Progeria
Syndrome
(HGPS)
aged
cells,
highlights
significance
related
proteins
ageing
age-related
disorders.
Interestingly,
as
effects
spaceflight
closely
resemble
those
found
elderly,
seems
induce
an
accelerated
phenotype
astronauts.
Therefore,
this
review
will
explore
microgravity,
further
elucidate
interplay
loss
gravitational
loading
ageing.
Abstract
Space
travel
is
a
growing
area
of
interest
and
includes
initiatives
such
as
NASA’s
Moon-to-Mars
Mission.
Reports
on
the
cardiovascular
effects
space
reveal
changes
in
morphology,
metabolism,
function
system.
In
this
study,
response
to
immunization
was
studied
mice
which
were
housed
immunized
while
International
Station
(ISS).
Mice
with
tetanus
toxoid
combined
adjuvant
CpG
(TT
+
CpG)
vaccination
using
transcriptomics.
Analysis
mouse
heart
transcriptome
performed
flight
control
flight-immunized
mice.
The
results
show
that
aboard
ISS
stimulates
heightened
inflammation
via
induction
nuclear
factor
kappa
B
(NF-κB)
signaling
pathway
promote
release
pro-inflammatory
cytokines
IFNγ,
IL-17
IL-6.
Additional
transcriptomic
included
alterations
cytoskeleton
expression
transcripts
associated
protection
from
oxidative
stress.
summary,
can
occur
following
space.
This
investigation
explores
impact
immune
challenges
lays
groundwork
for
future
research
into
additional
cardiac
during
spaceflight.
