The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process

Biomolecules, Год журнала: 2024, Номер 14(11), С. 1387 - 1387

Опубликована: Окт. 31, 2024

One-carbon (1C) metabolism is a complex network of metabolic reactions closely related to producing 1C units (as methyl groups) and utilizing them for different anabolic processes, including nucleotide synthesis, methylation, protein reductive metabolism. These pathways support the high proliferative rate cancer cells. While drugs that target (like methotrexate) have been used treatment, they often significant side effects. Therefore, developing new with minimal effects necessary effective treatment. Methionine, glycine, serine are main three precursors vital not only cells but also non-proliferative in regulating energy homeostasis aging process. Understanding potential role crucial advancing our knowledge neoplastic progression. This review provides comprehensive understanding molecular complexities context aging, paving way researchers explore avenues advanced therapeutic interventions cancer.

Язык: Английский

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The proximate composition, amino acid profile, fatty acid content, and mineral content of scale flour from three fish species as potential feeds for fish fry

F1000Research, Год журнала: 2023, Номер 12, С. 1144 - 1144

Опубликована: Сен. 13, 2023

Background: Fish scale waste is highly valued both as a food additive and functional ingredient. This study aimed to analyse the chemical composition, fatty acid profile, mineral content in fish flour of Osphronemus (O) goramy, Cyprinus (C) carpio, Oreochromis (O) niloticus potential feed for fry. Methods: scales were cleaned with 10% w/v NaCl solution at ratio of 1:10 (w/w) 24 hours 4 °C. Agitation was used every eight remove excess protein. Fish evenly arranged cooker cooked 121 °C 10 minutes 15 psi pressure. After cooking, 100 grams wet dried 50 four hours. Dried processed into analysis proximatel amino content, content. Results: The examined from three species displayed significant variations components, acids, minerals (p<0.01). Crude protein spanned 49.52% 72.94%, fat ranged 0.11% 0.23%. Magnesium levels varied between 767.82 mg/kg 816.50 mg/kg, calcium 3.54 12.16 iron within 40.46 44.10 zinc 45.80 139.19 mg/kg. Predominantly, glycine emerged main free (FAA), varying 13.70% 16.08%, while histidine had lowest 0.39% 0.71%. Conversely, among species, ranging 6.73% 9.48%. Conclusions: Scale farmed types showed fry due its composition contents. To enhance essential enriching oils containing eicosapentaenoic (EPA), docosahexaenoic (DHA), α-linolenic (ALA) essential

Язык: Английский

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Development of the Composition and Technology of Capsules Containing Peony Evadiant Rhizomes and Roots Dry extract and Glycine

Drug development & registration, Год журнала: 2023, Номер 12(4), С. 53 - 58

Опубликована: Дек. 22, 2023

Introduction. The development of dosage forms sedative action is an urgent task pharmaceutical technology in view the prevalence diseases nervous system. Peony rhizomes and roots dry extract combination with glycine have a anxiolytic effect, which associated improvement psycho-emotional state. Taking into account physicochemical characteristics composition biologically active substances peony roots, it necessary to select auxiliary that improve its technological properties. Aim. Development hard gelatin capsules containing glycine. Materials methods. Objects research – (LLC "Kazan Extract Plant", Russia), (JSC "Biokhimik", Russia). Excipients: apple pectin TD "HIMMED", starch aerosil lactose microcrystalline cellulose basic magnesium carbonate oxide Results discussion. for obtaining glycine, been substantiated. quality indicators developed were determined. Conclusion. has developed, selected ensure satisfactory properties mass filling capsules.

Язык: Английский

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