Translational Neurodegeneration,
Год журнала:
2025,
Номер
14(1)
Опубликована: Фев. 17, 2025
Abstract
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder.
PD
patients
exhibit
varying
degrees
of
abnormal
glucose
metabolism
throughout
stages.
Abnormal
closely
linked
to
pathogenesis
and
progression.
Key
processes
involved
in
include
transport,
glycolysis,
tricarboxylic
acid
cycle,
oxidative
phosphorylation,
pentose
phosphate
pathway,
gluconeogenesis.
Recent
studies
suggest
that
a
potential
therapeutic
target
for
PD.
In
this
review,
we
explore
connection
between
metabolism,
focusing
on
underlying
pathophysiological
mechanisms.
We
also
summarize
drugs
related
based
results
from
current
cellular
animal
model
studies.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 5, 2024
Abstract
Background
Inadequate
nerve
regeneration
and
an
inhibitory
local
microenvironment
are
major
obstacles
to
the
repair
of
spinal
cord
injury
(SCI).
The
activation
differentiation
fate
regulation
endogenous
neural
stem
cells
(NSCs)
represent
one
most
promising
approaches.
Metformin
has
been
extensively
studied
for
its
antioxidative,
anti-inflammatory,
anti-aging,
autophagy-regulating
properties
in
central
nervous
system
diseases.
However,
effects
metformin
on
NSCs
remains
be
elucidated.
Methods
proliferation
abilities
were
evaluated
using
CCK-8
assay,
EdU/Ki67
staining
immunofluorescence
staining.
Changes
expression
key
proteins
related
ferroptosis
detected
Western
Blot
levels
reactive
oxygen
species,
glutathione
tissue
iron
measured
corresponding
assay
kits.
mitochondrial
morphology
membrane
potential
observed
transmission
electron
microscopy
JC-1
fluorescence
probe.
Locomotor
function
recovery
after
SCI
rats
was
assessed
through
BBB
score,
LSS
CatWalk
gait
analysis,
electrophysiological
testing.
AMPK
pathway
examined
Blot.
Results
promoted
neuronal
both
vitro
vivo.
Furthermore,
a
model
erastin
treatment
established
vitro,
could
reverse
changes
ferroptosis-related
proteins,
increase
synthesis,
reduce
species
production
improve
morphology.
Moreover,
administration
improved
locomotor
histological
outcomes
following
rats.
Notably,
all
above
beneficial
completely
abolished
upon
addition
compound
C,
specific
inhibitor
AMP-activated
protein
kinase
(AMPK).
Conclusion
Metformin,
driven
by
canonical
AMPK-dependent
regulation,
promotes
while
inhibiting
ferroptosis,
thereby
facilitating
SCI.
Our
study
further
elucidates
protective
mechanism
SCI,
providing
new
mechanistic
insights
candidacy
as
therapeutic
agent
Translational Neurodegeneration,
Год журнала:
2025,
Номер
14(1)
Опубликована: Фев. 17, 2025
Abstract
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder.
PD
patients
exhibit
varying
degrees
of
abnormal
glucose
metabolism
throughout
stages.
Abnormal
closely
linked
to
pathogenesis
and
progression.
Key
processes
involved
in
include
transport,
glycolysis,
tricarboxylic
acid
cycle,
oxidative
phosphorylation,
pentose
phosphate
pathway,
gluconeogenesis.
Recent
studies
suggest
that
a
potential
therapeutic
target
for
PD.
In
this
review,
we
explore
connection
between
metabolism,
focusing
on
underlying
pathophysiological
mechanisms.
We
also
summarize
drugs
related
based
results
from
current
cellular
animal
model
studies.
