International Journal of Biological Sciences,
Год журнала:
2024,
Номер
21(2), С. 595 - 613
Опубликована: Дек. 31, 2024
Cognitive
impairment
caused
by
anesthesia
and
surgery
is
one
of
the
most
common
complications
with
multiple
etiologies
that
occurs
in
elderly
patients.The
underlying
mechanisms
are
not
fully
understood,
there
a
lack
therapeutic
strategies.Increasing
evidence
has
demonstrated
myelin
loss,
abnormal
phosphorylation
tau
protein
neuronal
apoptosis
substantial
driving
factors
cognitive
deficits.However,
key
regulatory
involved
pathology
postoperative
dysfunction
require
further
investigation.Herein,
we
identified
regulator,
Lingo1,
whose
expression
significantly
increased
hippocampal
neurons
after
aged
mice
underwent
unilateral
nephrectomy.Elevated
Lingo1
markedly
activated
RhoA/ROCK1
signaling
pathway
through
interactions
NgR
p75NTR,
subsequently
promoting
loss
protein.Moreover,
upregulation
inhibited
EGFR/PI3K/Akt
pathway,
which
may
increase
apoptosis.These
pathological
changes
ultimately
lead
to
surgery.Notably,
knockdown
reversed
hippocampus
attenuated
decline.In
conclusion,
our
findings
highlight
promotes
occurrence
development
regulating
apoptosis,
suggesting
might
be
potential
target
for
treating
dysfunction.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Март 26, 2024
With
the
aging
of
population,
health
elderly
has
become
increasingly
important.
Postoperative
cognitive
dysfunction
(POCD)
is
a
common
neurological
complication
in
patients
following
general
anesthesia
or
surgery.
It
characterized
by
decline
that
may
persist
for
weeks,
months,
even
longer.
Electroacupuncture
(EA),
novel
therapy
combines
physical
nerve
stimulation
with
acupuncture
treatment
from
traditional
Chinese
medicine,
holds
potential
as
therapeutic
intervention
preventing
and
treating
POCD,
particularly
patients.
Although
beneficial
effects
EA
on
POCD
have
been
explored
preclinical
clinical
studies,
reliability
limited
methodological
shortcomings,
underlying
mechanisms
remain
largely
unexplored.
Therefore,
we
synthesized
existing
evidence
proposed
biological
neuroinflammation,
oxidative
stress,
autophagy,
microbiota-gut-brain
axis,
epigenetic
modification.
This
review
summarizes
recent
advances
provides
theoretical
foundation,
explores
molecular
prevention
offers
basis
conducting
relevant
trials.
Brain and Behavior,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Background
The
occurrence
and
development
of
postoperative
cognitive
dysfunction
(POCD)
are
closely
linked
to
neuroinflammation.
This
bibliometric
analysis
aims
provide
novel
insights
into
the
research
trajectory,
key
topics,
potential
future
trends
in
field
neuroinflammation‐induced
POCD.
Methods
Web
Science
Core
Collection
(WoSCC)
database
was
searched
identify
publications
from
2012
2023
on
Bibliometric
analysis,
involving
both
statistical
visual
analyses,
conducted
using
CiteSpace,
VOSviewer,
R
software.
Results
Research
POCD
has
exhibited
an
increasing
trend
over
past
12
years.
China
had
highest
number
publications,
Nanjing
Medical
University
most
collaboration
with
other
institutions,
Zhiyi
Zuo
published
author,
Journal
Neuroinflammation
served
as
primary
publication
frequent
keyword
Keyword
clustering
indicated
that
predominant
cluster
is
dexmedetomidine.
Burst
detection
revealed
delirium
(POD),
perioperative
neurocognitive
disorders
(PND),
apoptosis,
epigenetic
modifications
were
trends.
Conclusions
Our
identified
following
areas
associated
POCD:
anesthesia,
surgery,
dexmedetomidine,
NLRP3
inflammasome,
mechanism
topics
comprise
POD,
PND,
modifications.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Март 13, 2024
Abstract
Circular
RNAs
(circRNAs)
have
garnered
significant
attention
in
the
field
of
neurodegenerative
diseases
including
Alzheimer’s
due
to
their
covalently
closed
loop
structure.
However,
involvement
circRNAs
postoperative
cognitive
dysfunction
(POCD)
is
still
largely
unexplored.
To
identify
genes
differentially
expressed
between
non-POCD
(NPOCD)
and
POCD
mice,
we
conducted
whole
transcriptome
sequencing
initially
this
study.
According
expression
profiles,
observed
that
circAKT3
was
associated
with
hippocampal
neuronal
apoptosis
mice.
Moreover,
found
overexpression
reduced
neurons
alleviated
POCD.
Subsequently,
through
bioinformatics
analysis,
our
data
showed
vitro
vivo
elevated
abundance
miR-106a-5p
significantly,
resulting
a
decrease
HDAC4
protein
an
increase
MEF2C
protein.
Additionally,
effect
blocked
by
inhibitor.
Interestingly,
could
activate
transcription
promoter
form
positive
feedback
loop.
Therefore,
findings
revealed
more
potential
modulation
ways
circRNA-miRNA
miRNA-mRNA,
providing
different
directions
targets
for
preclinical
studies
To
investigate
the
impact
of
goal-directed
fluid
therapy
(GDFT)
on
postoperative
cognitive
dysfunction
(POCD)
in
elderly
patients
with
colorectal
cancer,
we
conducted
a
randomized
controlled
trial.
Eighty
who
underwent
elective
laparoscopic
radical
resection
cancer
were
randomly
assigned
to
either
GDFT
group
or
conventional
group.
The
primary
outcome
was
incidence
POCD
during
initial
7
days,
while
secondary
outcomes
included
inflammatory
marker
levels
such
as
interleukin-6
(IL-6)
and
S100β
protein,
hemodynamics,
level
lactic
acid,
functional
recovery,
complications.
Among
88
patients,
80
evaluable
for
outcome.
significantly
lower
(15.0%)
compared
(30.0%),
highest
occurrence
observed
day
3
postoperatively
both
groups
(
Molecular Neurobiology,
Год журнала:
2024,
Номер
61(12), С. 10861 - 10882
Опубликована: Май 27, 2024
The
pathophysiological
regulatory
mechanisms
in
postoperative
neurocognitive
disorders
(PNCDs)
are
intricately
complex.
Currently,
the
pathogenesis
of
PNCDs
has
not
been
fully
elucidated.
mechanism
involved
may
include
a
variety
factors,
such
as
neuroinflammation,
oxidative
stress,
and
neuroendocrine
dysregulation.
Research
into
gut
microbiota-induced
regulations
on
brain
functions
is
increasingly
becoming
focal
point
exploration.
Emerging
evidence
shown
that
intestinal
bacteria
play
an
essential
role
maintaining
homeostasis
various
physiological
systems
regulating
disease
occurrence.
Recent
studies
have
confirmed
association
gut-brain
axis
with
central
nervous
system
diseases.
However,
effects
this
remain
unclear.
Therefore,
paper
intends
to
review
bidirectional
signaling
PNCDs,
summarize
latest
research
progress,
discuss
possible
affecting
This
aimed
at
providing
scientific
reference
for
predicting
clinical
risk
PNCD
patients
identifying
early
diagnostic
markers
prevention
targets.
Brain Research Bulletin,
Год журнала:
2024,
Номер
216, С. 111034 - 111034
Опубликована: Июль 23, 2024
Elderly
individuals
undergoing
surgical
procedures
are
often
confronted
with
the
peril
of
experiencing
postoperative
cognitive
dysfunction
(POCD).
Prior
research
has
demonstrated
exacerbating
effect
sevoflurane
anesthesia
on
neuroinflammation,
which
can
further
deteriorate
condition
POCD
in
elderly
patients.
Intermittent
fasting
(IF)
restricts
food
consumption
to
a
specific
time
window
and
been
ameliorate
induced
by
neuropathic
inflammation.
We
subjected
18-month-old
male
mice
16
hours
8
unrestricted
eating
over
24-hour
period
for
0,
1,
2,
4
weeks,
followed
abdominal
exploration
under
anesthesia.
In
this
study,
we
aim
explore
potential
impact
IF
function
aged
surgery
through
preoperative
implementation
measures.
The
findings
indicate
two
weeks
leads
significant
enhancement
learning
memory
capabilities
following
surgery.
performance,
as
determined
novel
object
recognition
Morris
water
maze
tests,
well
synaptic
plasticity,
measured
vivo
electrophysiological
recordings,
marked
improvements.
Furthermore,
administration
markedly
enhances
expression
synaptic-associated
proteins
hippocampal
neurons,
concomitant
decreasing
pro-inflammatory
factors
reduced
density
microglial
cells
within
brain
region.
To
summarize,
results
study
that
may
mitigate
inflammation
area
brain.
appears
provide
safeguard
against
impairment
plasticity
brought
