Case Report: Efficacy of ofatumumab in refractory anti-NMDAR encephalitis: case series and literature review

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 12, 2025

Anti-NMDAR encephalitis is the most common autoimmune encephalitis. When first-line treatments fail, second-line therapies are employed. However, a standardized approach for treatment has yet to be established. We presented three cases of anti-NMDAR with seizures and psychosis as primary symptom. These patients showed inadequate response initial treatments, including intravenous immunoglobulin, methylprednisolone, plasma exchange. their symptoms were effectively controlled following subcutaneous administration ofatumumab. Previous studies have reported that twelve treated In this study, modified Rankin scale (mRS) scores at last follow-up all fifteen (including our cases) significantly lower compared peak disease (p < 0.001). Thirteen achieved full recovery. findings suggest CD20 monoclonal antibodies, particularly ofatumumab, may offer promising option

Язык: Английский

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Exploring the Potential of Precision Medicine in Neuropsychiatry: A Commentary on New Insights for Tailored Treatments Based on Genetic, Environmental, and Lifestyle Factors

Genes, Год журнала: 2025, Номер 16(4), С. 371 - 371

Опубликована: Март 24, 2025

Neuropsychiatric disorders are complex conditions with multifactorial etiologies, in which genetics play a pivotal role. Despite significant advancements psychiatric research, traditional treatment options remain largely symptomatic, focusing on clinical signs without fully addressing the underlying biological causes. However, recent developments precision medicine—an approach that tailors treatments based genetic, environmental, and lifestyle factors—hold great promise for transforming of these disorders. By identifying specific genetic markers understanding gene–environment interactions, medicine can offer more personalized effective treatments, leading to better patient outcomes. Our primary aim was explore how integrating data environmental factors could enhance neuropsychiatric such as schizophrenia, bipolar disorder, depression. The secondary examine potential pharmacogenomics gene therapy improving therapeutic strategies. results indicate while progress has been made, challenges remain, including complexity interactions need granular phenotypic data. In conclusion, revolutionize by providing individualized care considers makeup, influences, factors, paving way therapies improved

Язык: Английский

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Biological mechanisms, pharmacological and pathological activities, and quality optimization of gingerols and shogaols

Journal of Functional Foods, Год журнала: 2025, Номер 127, С. 106773 - 106773

Опубликована: Апрель 1, 2025

Язык: Английский

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Agarwood as a neuroprotective agent: a comprehensive review of existing evidence and potential avenues for future research

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

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Integrated metabolomic analysis and network medicine to investigate the mechanisms of Jingling oral liquid in treating ADHD

Deleted Journal, Год журнала: 2025, Номер unknown, С. 200214 - 200214

Опубликована: Апрель 1, 2025

Язык: Английский

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