2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM),
Год журнала:
2023,
Номер
unknown, С. 2790 - 2797
Опубликована: Дек. 5, 2023
The
landscape
of
cognitive
states
and
their
underlying
neurobiological
mechanisms
has
been
significantly
illuminated
through
advancements
in
neuroimaging
computational
modeling.
This
study
introduces
an
integrated
approach
that
harnesses
network
analysis
machine
learning
techniques
to
characterize
differentiate
groups—Normal
Control
(NC),
Mild
Cognitive
Impairment
(MCI),
Alzheimer's
Disease
(AD).
Structural
networks
are
formulated
analyzed
based
on
diffusion
tensor
data
a
fusion
graph
theory
mass-spring
model
methodologies.
Notably,
features
extracted
from
both
theoretic
computations
drive
two-step
framework.
process
commences
with
random
forest-based
feature
extraction,
followed
by
support
vector-based
classification
approach,
culminating
impressive
accuracy
82.7%
for
classifying
individuals
across
groups,
AUC
0.893.
significance
is
underscored
the
pressing
need
enhanced
impairment
detection
differentiation
strategies.
identified
offer
nuanced
insights
into
intricate
interplay
among
brain
structure,
dynamics,
function,
thereby
bridging
gaps
our
understanding
decline
neurodegeneration.
By
fortifying
diagnostic
repertoire
facilitating
personalized
interventions,
this
research
paves
way
refined
clinical
practices.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(5)
Опубликована: Фев. 17, 2024
Cerebral
organoids
are
three‐dimensional
(3D)
aggregates
with
a
more
advanced
composition,
maturation,
and
architecture.
It
has
emerged
as
novel
sophisticated
model
system
for
studying
neurodevelopment
neurological
disorders,
in
comparison
to
conventional
two‐dimensional
(2D)
cell
cultures.
However,
due
the
extraordinarily
complex
nature
of
brain
development,
current
cerebral
not
functional
mature
brains.
The
development
requires
culture
sufficient
developmental
patterning
factors,
essential
components,
vasculature.
In
this
review,
critical
factors
events
that
contribute
focused
on.
design,
fabrication
techniques,
technologies
also
discussed
enhance
application
potential
organoid
technology.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 1, 2024
Abstract
Alzheimer's
Disease
(AD)
is
a
neurodegenerative
disorder
characterized
primarily
by
cognitive
impairment.
The
motivation
of
this
paper
to
explore
the
features
visual
information
transmission
pathway
(V-H
pathway)
when
AD
occurs.
following
were
observed:
1.
Hemoglobin
expression
on
brain
regions
V-H
becomes
dysregulated
as
2.
more
dysfunctional.
According
features,
conclusion
was
proposed:
As
neurofibrillary
tangles
(NFTs)
increase,
and
abnormal
tau
proteins
penetrate
bloodstream
arrive
at
pathway.
hemoglobin
molecules
have
higher
risk
attacking
or
other
toxic
substances.
Under
attack
substances,
dysregulated,
This
dysfunction
has
an
impact
early
symptoms
AD,
such
spatial
recognition
face
disorder.
Cognitive
impairment
and
Alzheimer's
disease
related
dementias
(ADRD)
pose
significant
challenges
for
Indigenous
populations,
necessitating
urgent
research.
Limited
evidence
suggests
that
high
rates
of
ADRD
among
peoples
are
associated
with
social
determinants
health
(SDOH),
such
as
education,
income,
literacy,
religion,
engagement.
Collaborating
a
Northern
Plains
tribe,
participants
were
recruited
123
self-identified
women
aged
40-70
through
comprehensive
recruitment
strategy.
Employing
the
SDOH
framework,
research
assessed
cognitive
knowledge
(ADK),
utilizing
Ascertain
Dementia
8
scales
(ADK-30).
The
investigation
examined
relationships
between
selected
variables
status.
More
than
half
showed
signs
impairment,
which
correlated
lower
income
education
levels.
Increased
about
disease,
particularly
in
terms
treatment
management
its
life
impact
subscales,
was
odds
impairment.
Conversely,
higher
levels
depressive
symptoms
participation
religious
activities
linked
to
increased
findings
underscore
importance
culturally
grounded
tools
frameworks
tailored
contexts
addressing
disparities.
Future
should
integrate
historical
cultural
factors
advance
equity
within
communities,
ultimately
mitigating
promoting
overall
well-being.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 8, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
characterized
primarily
by
cognitive
impairment.
The
motivation
of
this
paper
to
explore
the
impact
visual
information
transmission
pathway
(V–H
pathway)
on
AD,
and
following
feature
were
observed:
Hemoglobin
expression
V–H
becomes
dysregulated
as
AD
occurs
so
dysfunctional.
According
feature,
conclusion
was
proposed:
As
occurs,
abnormal
tau
proteins
penetrate
bloodstream
arrive
at
brain
regions
pathway.
Then
or
other
toxic
substances
attack
hemoglobin
molecules.
Under
attack,
more
dysregulated.
dysfunction
has
an
early
symptoms
such
spatial
recognition
face
disorder.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
AbstractBackground:
The
research
community
has
historically
failed
to
enroll
diverse
groups
of
participants
in
dementia
clinical
trials.
A
unique
aspect
care
is
the
requirement
a
study
partner,
who
can
attest
recipient’s
and
functional
capacity.
aim
this
assess
racial
ethnic
differences
importance
various
trial
considerations
among
caregivers,
their
decision
participate
as
partners.Method:
We
embedded
vignette
about
hypothetical
nationally
representative
survey
U.S.
oversampling
non-Hispanic
Black
Hispanic
caregivers.
Dementia
caregivers
were
asked
willingness
with
recipient
rated
nine
decisions
participate.
Caregiver
demographic
characteristics
analyzed
predictors
participation
base
model.
In
second
reasons
model
caregiver
separately
predictors;
both
models
used
survey-weighted
logistic
regression.Result:
sample
consisted
610
including
156
122
participants.
model,
was
negatively
associated
older
age
(OR
(odds
ratio)
=
0.72,
p
<
0.001).
social
responsibility
help
others
by
participating
significantly
1.56,
0.049),
while
possibility
experiencing
serious
side
effects
0.51,
0.003).
there
no
significant
difference
between
White
or
caregivers.Conclusion:
not
less
likely
than
trial.
Our
suggests
that
failures
recruit
populations
are
attributable
members
underrepresented
but
may
instead
reflect
structural
barriers
historic
exclusion
from
participation.
Clinical Science,
Год журнала:
2024,
Номер
138(21), С. 1329 - 1341
Опубликована: Окт. 2, 2024
Endothelin-1
(ET-1),
the
most
potent
vasoconstrictor
identified
to
date,
contributes
cerebrovascular
dysfunction.
ET-1
levels
in
postmortem
brain
specimens
from
individuals
diagnosed
with
Alzheimer's
disease
(AD)
and
related
dementias
(ADRD)
were
shown
be
cerebral
hypoxia
severity.
ET-1-mediated
vascular
dysfunction
ensuing
cognitive
deficits
have
also
been
reported
experimental
models
of
AD
ADRD.
Moreover,
studies
showed
that
secreted
microvascular
endothelial
cells
(BMVECs)
can
affect
neurovascular
unit
integrity
an
autocrine
paracrine
manner.
Vascular
contributions
impairment
dementia
(VCID)
is
a
leading
ADRD
cause
known
free
neuronal
tau
pathology,
hallmark
AD.
However,
recent
study
cytotoxic
hyperphosphorylated
(p-tau)
accumulation,
which
fails
bind
or
stabilize
microtubules
BMVECs
VCID.
Thus,
aimed
determine
impact
on
microtubule
organization,
barrier
function
BMVECs.
Cells
stimulated
1
μM
for
24
h
presence/absence
ETA
(BQ123;
20
μM)
ETB
(BQ788;
receptor
antagonists.
Cell
lysates
assayed
array
phosphorylation
site-specific
antibodies
organization/stabilization
markers.
stimulation
increased
p-tau
Thr231
but
decreased
Ser199,
Ser262,
Ser396,
Ser214
only
presence
antagonism.
impaired
These
novel
findings
suggest
(1)
dysregulation
may
contribute
(2)
ET
system
early
intervention
target
prevent
tau-mediated
disruption
BMVEC
function.
Jurnal Edukasi Ilmiah Kesehatan,
Год журнала:
2024,
Номер
2(3), С. 86 - 93
Опубликована: Ноя. 22, 2024
Introduction:
Obesity
has
been
identified
as
one
of
the
main
risk
factors
contributing
to
increase
in
hypertension
cases,
particularly
among
elderly.
This
study
aims
analyze
role
obesity
increasing
elderly
by
examining
relationship
between
body
mass
index
(BMI)
and
blood
pressure.
Methods:
research
uses
a
cross-sectional
design,
an
analytical
that
studies
causes
incidents
or
incidents.
Data
collection
questionnaire.
The
sample
this
was
64
hypertensive
patients
working
data
analysis
using
chi-square
test.
Results:
study's
results
indicate
(p=0.000)
incidence
working.
showed
with
obese
status
had
significantly
higher
compared
average
weight.
Conclusions:
These
findings
underscore
importance
preventing
treating
reduce
other
health
complications.
is
expected
contribute
formulating
policies
prevention
programs
through
practical
weight
management
approach
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM),
Год журнала:
2023,
Номер
unknown, С. 2790 - 2797
Опубликована: Дек. 5, 2023
The
landscape
of
cognitive
states
and
their
underlying
neurobiological
mechanisms
has
been
significantly
illuminated
through
advancements
in
neuroimaging
computational
modeling.
This
study
introduces
an
integrated
approach
that
harnesses
network
analysis
machine
learning
techniques
to
characterize
differentiate
groups—Normal
Control
(NC),
Mild
Cognitive
Impairment
(MCI),
Alzheimer's
Disease
(AD).
Structural
networks
are
formulated
analyzed
based
on
diffusion
tensor
data
a
fusion
graph
theory
mass-spring
model
methodologies.
Notably,
features
extracted
from
both
theoretic
computations
drive
two-step
framework.
process
commences
with
random
forest-based
feature
extraction,
followed
by
support
vector-based
classification
approach,
culminating
impressive
accuracy
82.7%
for
classifying
individuals
across
groups,
AUC
0.893.
significance
is
underscored
the
pressing
need
enhanced
impairment
detection
differentiation
strategies.
identified
offer
nuanced
insights
into
intricate
interplay
among
brain
structure,
dynamics,
function,
thereby
bridging
gaps
our
understanding
decline
neurodegeneration.
By
fortifying
diagnostic
repertoire
facilitating
personalized
interventions,
this
research
paves
way
refined
clinical
practices.
