Plasma GFAP, NfL and pTau 181 detect preclinical stages of dementia

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Апрель 9, 2024

Background Plasma biomarkers are preferable to invasive and expensive diagnostic tools, such as neuroimaging lumbar puncture that gold standard in the clinical management of Alzheimer’s Disease (AD). Here, we investigated plasma Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light Chain (NfL) Phosphorylated-tau-181 (pTau 181) AD its early stages: Subjective cognitive decline (SCD) Mild impairment (MCI). Material methods This study included 152 patients (42 SCD, 74 MCI 36 AD). All underwent comprehensive neurological assessment. Blood samples were collected for Apolipoprotein E (APOE) genotyping biomarker (GFAP, NfL, pTau measurements. Forty-three (7 27 MCI, 9 AD) a follow-up (FU) visit after 2 years, second sample was collected. levels detected using Simoa SR-X technology (Quanterix Corp.). Statistical analysis performed SPSS software version 28 (IBM Statistics). significance set at p < 0.05. Results GFAP, NfL 181 lower SCD than patients. In particular, GFAP statistically significant different between ( =0.003), =0.032). vs =0.026), <0.001), FU p=0.033 ), p=0.011 =0.002), =0.003) =0.003). concentration significantly =0.001), =0.020). APOE ϵ4 carriers, increase p<0.001 ) found p=0.014). Moreover, an association emerged age disease onset (p = 0.021) pTau181 0.001) levels. Discussion conclusions promising diagnosis prodromic stages prognosis dementia.

Язык: Английский

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Inflammation and aging-related disease: A transdisciplinary inflammaging framework

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee

Journal of the American Geriatrics Society, Год журнала: 2024, Номер 72(9), С. 2942 - 2950

Опубликована: Март 14, 2024

Abstract The International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee aims to improve the use drugs in older adults develop new therapeutic approaches for syndromes diseases old age through advocacy, education, research. In present paper, we propose strategies relevant drug development evaluation, spanning preclinical full range clinical studies. Drugs need consider not only age, but also other characteristics common geriatric patients, such as multimorbidity, polypharmacy, falls, cognitive impairment, frailty. IUPHAR Committee's position statement on ‘Measurement Frailty Drug Development Evaluation’ is included, highlighting 12 key principles that cover spectrum translational We where are likely be major users a drug, frailty measured at baseline an outcome. Preclinical models replicate frailty, duration exposure, comorbidities, co‐medications proposed patients may translation. highlight potential application recent technologies, physiologically based pharmacokinetic–pharmacodynamic modeling informed by biology, Artificial Intelligence, inform personalized medicine patients. Considerations rapidly aging populations low‐ middle‐income countries related health‐care trials outlined. Involving adults, their caregivers providers all phases research should development, outcomes internationally.

Язык: Английский

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Age difference in the connection between systemic inflammatory response and metabolic syndrome

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Abstract Background This research aims to investigate the connection between systemic inflammatory response and metabolic syndrome (MetS) across different age groups, with aim of proposing more targeted recommendations. Methods study enrolled 15 959 adults from 2001-2018 National Health Nutrition Examination Survey whom 6739 were diagnosed MetS. After dividing immune-inflammation index (SII) into 4 quartiles, Kruskal–Wallis test weighted chi-square employed assess statistical differences. Weighted multivariable logistic regression analysis, subgroup sensitivity restricted cubic spline examine relationship SII Results Our revealed that exhibits a quantitative association MetS [odds ratio (OR) = 1.56; 95% confidence interval (CI): 1.37-1.79; P < .001]. Elevated is an independent risk factor for 5 components Different groups alcohol consumption status could modify was statistically significant in 18 65 group but not elderly (OR 1.08; CI, .95-1.23; .248). Multiple imputation confirmed robustness our results. Moreover, inverted U-shaped curve. Conclusion highlights predictive significance forecasting incidence young middle-aged populations. The differences mechanisms various necessitate further exploration.

Язык: Английский

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Frailty as a Predictor of Net Clinical Benefit in Atrial Fibrillation Patients Over 60 Receiving Anticoagulants: Insights from the Single-Center Prospective REGATTA-2 Registry

Russian Journal of Geriatric Medicine, Год журнала: 2025, Номер 1, С. 49 - 57

Опубликована: Фев. 19, 2025

Studying the frailty in patients with atrial fibrillation (AF) is essential given high prevalence of AF and escalating risk strokes bleeding as individuals age. AIM : to evaluate effect on sum thromboembolic events bleedings aged 60 years older receiving anticoagulants. MATERIALS AND METHODS . This fragment from single-center prospective REGATTA-2 register (Register long-term Antithrombotic therapy -NCT043447187) included 455 ≥ for whom it was possible assess signs three scales Groningen Frailty Index, FRAIL «Age not a hindrance». During follow-up (median 6 years), were taken into. RESULTS according Index detected 29.7% 31.8%, using hindrance» scale — 9.5% patients. The most common syndromes emotional cognitive disorders, fatigue limited mobility. According ROC analysis, all used had predictive value relation bleedings. Independent predictors (Cox proportional risks model) are 4 (HR=1.8) 3 (HR=1.6). CONCLUSION Frail have an increased bleedings; therefore, they need personalized monitoring treatment regimen.

Язык: Английский

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Editorial: Diagnostic, prognostic and treatment efficacy power of biomarkers of aging for frailty, age-related diseases and multimorbidity

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 10, 2025

papers have been previously demonstrated to be formally associated with age, so it is possible that some of them maintain the association observed outcome only in particular condition has reported paper.Fourteen original research are included this Research Topic, describing results from studies dealing different aspects biomarkers. In particular, soluble biomarkers, including metabolites investigated diverse clinical or real-world settings. Genetics and epigenetics, as well functional parameters investigated, too.In far a machine learning- As whole, collection helps shed light on emerging topic biomarkers age useful tools identify people patients at risk for specific conditions or, more general, frailty mortality, evaluate efficacy preventive therapeutic treatments, not mention possibility these per se targets anti-aging treatments. More extended (possibly) longitudinal will needed confirm whether findings could translated into practice diagnostic prognostic purposes. §S.S. receiving funds Next Generation EU, context National Recovery Resilience Plan, Investment PE8 -Project Age-It: "Ageing Well an Ageing Society" CUP: B83C22004800006

Язык: Английский

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Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 1, 2025

Recent evidence from clinical and animal studies with anti-inflammatory agents in depression is conflicting. One possible reason the heterogeneity of baseline inflammation levels. Since older adults are generally associated chronic low-grade one most common mental disorders this population, meta-analysis aimed to evaluate therapeutic preventative effects interventions for among adults. PubMed, Cochrane Library, Embase, PsycINFO were searched randomized controlled trials (RCTs) up November 18, 2024. The primary outcomes mean change scores incidences after treatment. Pooled standard differences (SMDs) odds ratios (ORs) including 95% confidence intervals (95% CI) calculated. Of 3116 screened articles, 31 RCTs met inclusion criteria, 25 investigating efficacy 7 incidence following Anti-inflammatory statistically significantly more effective than placebo reducing depressive (SMD = −0.57, CI −0.98 −0.15, p 0.008). Sub-group analyses supported use omega-3 fatty acids −0.14, −0.27 −0.02, 0.03) botanical drug or dietary intervention −0.86, −1.58 −0.13, 0.02) participants. While limited by substantial included studies, these results reveal moderate beneficial treatment prevention Future high-quality warranted determine which preferential patients depression.

Язык: Английский

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Explainable machine learning framework for biomarker discovery by combining biological age and frailty prediction

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 22, 2025

Язык: Английский

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Exploring the potential of epigenetic clocks in aging research

Methods, Год журнала: 2024, Номер 231, С. 37 - 44

Опубликована: Сен. 7, 2024

Язык: Английский

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The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Дек. 2, 2024

Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, where and death nucleus pulposus cells within intervertebral (IVD) can be obviously revealed. This result in an imbalance extracellular matrix due to loss proteoglycans water content, which further lead catabolic anabolic dysfunction IVD. Recently, cartilage endplate (CEP) during aging has drawn large attention its essential functions contributing nutrient exchange maintaining IVD homeostasis. Furthermore, inflammation disturbed homeostasis CEP not only accelerate degradation matrix, but also exacerbate IVDD by causing cell through other pathological factors. Here this review, we summarized possible factors underlying mechanisms inflammation-induced IVDD, including exosomes degeneration, calcification, ferroptosis, mechanical changes, senescence. Besides, changes miRNAs, pain-related neural reflex arc pathways associated with are reviewed. In addition, new strategies specifically designed for discussed last section. We hope paper offer some insights advancing novel treating serve as a valuable reference researchers field.

Язык: Английский

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