The Journal of Nutritional Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 109842 - 109842
Опубликована: Янв. 1, 2025
Glutamine
availability
may
be
reduced
in
chronic
diseases,
such
as
type
2
diabetes
mellitus
(T2DM)-induced
by
obesity.
Herein,
the
antioxidant,
anti-inflammatory
and
lipid
metabolism
effects
of
oral
glutamine
supplementation
its
free
dipeptide
form
were
assessed
ob/ob
mice.
Adult
male
C57BL/6J
mice
supplemented
with
L-alanyl-L-glutamine
(DIP)
or
L-glutamine
(GLN)
drinking
water
for
40
days,
whilst
Wild-type
lean
(WT)
control
(CTRL)
received
fresh
only.
Plasma
tissue
(skeletal
muscle
liver)
levels,
insulin
resistance
parameters
(e.g.,
GTT,
ITT,
insulin)
determined.
Oxidative
stress
GSH
system,
Nrf2
translocation),
inflammatory
NFkB
translocation,
TNF-α
gene
expression)
plasma
liver
triglyceride
SRBP-1,
FAS,
ACC,
ChRBP
also
analyzed.
CTRL
showed
lower
levels
tissue,
well
increased
fat
liver.
Conversely,
DIP
restored
tissues,
improved
glucose
homeostasis
levels.
Also,
restoration,
expression
was
observed
group.
Interestingly,
GLN
only
stores
but
overall
resistance,
attenuated
metabolic
biomarkers.
The
results
presented
herein
indicate
that
restoration
body
reduces
oxidative
inflammation
obese
T2DM
This
effect
hepatic
changes
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 13, 2024
Abstract
This
cross-sectional
study
investigated
differences
in
the
plasma
metabolome
two
groups
of
adults
that
were
similar
age
but
varied
markedly
body
composition
and
dietary
physical
activity
patterns.
Study
participants
included
52
lifestyle
group
(LIFE)
(28
males,
24
females)
control
(CON)
(27
25
females).
The
results
using
an
extensive
untargeted
ultra
high-performance
liquid
chromatography-high
resolution
mass
spectrometry
(UHPLC-HRMS)
metabolomics
analysis
with
10,535
metabolite
peaks
identified
486
important
metabolites
(variable
influence
on
projections
scores
VIP
≥
1)
16
significantly
enriched
metabolic
pathways
differentiated
LIFE
CON
groups.
A
novel
signature
positive
habits
emerged
from
this
highlighted
by
lower
levels
numerous
bile
acids,
amino
acid
profile
characterized
higher
histidine
glutamic
acid,
glutamine,
β-alanine,
phenylalanine,
tyrosine,
proline,
elevated
vitamin
D
status,
beneficial
fatty
acids
gut
microbiome
catabolism
plant
substrates,
reduced
N-glycan
degradation
environmental
contaminants.
established
is
strongly
associated
habits.
robust
consistent
improved
life
expectancy
a
risk
for
chronic
disease.
Medicina,
Год журнала:
2024,
Номер
60(10), С. 1647 - 1647
Опубликована: Окт. 8, 2024
The
most
prevalent
reason
for
vision
impairment
in
aging
inhabitants
is
age-related
macular
degeneration
(AMD),
a
posterior
ocular
disease
with
poor
understanding
of
the
anatomic,
genetic,
and
pathophysiological
progression
disease.
Recently,
new
insights
exploring
role
atrophic
changes
retinal
pigment
epithelium,
extracellular
drusen
deposits,
lysosomal
lipofuscin,
various
genes
have
been
investigated
AMD.
Hence,
this
review
explores
incidence
risk
factors
AMD,
such
as
oxidative
stress,
inflammation,
complement
system,
involvement
bioactive
lipids
their
angiogenesis.
In
addition
to
intravitreal
anti-vascular
endothelial
growth
factor
(VEGF)
therapy
other
therapeutic
interventions
oral
kinase
inhibitors,
photodynamic,
gene,
antioxidant
therapy,
well
benefits
drawbacks
AMD
treatment
options,
strategic
drug
delivery
methods,
including
routes
focus
on
pharmacokinetics,
are
investigated.
Further,
recent
advancements
nanoformulations
polymeric
lipid
nanocarriers,
liposomes,
etc.,
intended
pros
cons
too
summarized.
Therefore,
purpose
give
researchers
an
pathophysiology,
emphasis
angiogenesis,
function
lipids,
options.
Additionally,
options
that
development
system(s)
via
several
can
aid
advancement
choices.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
Animals,
Год журнала:
2025,
Номер
15(2), С. 173 - 173
Опубликована: Янв. 10, 2025
With
the
increasing
demand
for
enhancing
livestock
production
performance
and
optimizing
feed
efficiency,
this
study
aimed
to
investigate
effects
of
fermented
total
mixed
ration
(FTMR)
containing
different
proportions
rice
straw
sheath
leaves
Zizania
latifolia
on
systemic
nutrient
metabolism
oxidative
under
host
genetic
regulation
growth
heifers.
A
157
heifers
aged
7-8
months
were
selected,
their
hair
was
collected
whole-genome
sequencing.
They
randomly
assigned
into
four
groups
18
21
cattle
each
fed
FTMR
varying
levels
(21%
in
LSF,
28%
MSF,
35%
HSF)
or
31%
(ZF)
a
two-month
period.
At
end
trial,
blood
urine
samples
measure
biochemical
indexes
metabolomics.
The
results
showed
that
high
content
ZF
diets
could
increase
glucose
non-protein
nitrogen
heifers,
is,
urea
HSF
higher
than
those
LSF
MSF
(p
<
0.05).
Meanwhile,
two
improve
antioxidant
level
Urine
metabolomics
analysis
between
identified
three
differential
metabolic
pathways,
including
11
metabolites.
Among
them,
l-homoserine
o-acetylserine
had
significant
SNPs
associated
with
which
promoted
glutathione
metabolism.
Although
there
no
effect
diet
heifers'
average
daily
gain
(ADG)
body
weight
>
0.05),
substantial
inter-individual
variation
metabolites
among
all
animals,
as
further
correlation
analyses
illustrated.
Twenty-eight
significantly
ADG
(R
0.3,
p
Four
them
biomarkers,
primarily
regulating
energy
balance.
In
conclusion,
feeding
enhances
capacity
positioning
key
candidates
markers.
This
integrative
omics
approach
underscores
potential
productivity
promoting
sustainable
agricultural
practices.
The Journal of Nutritional Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 109842 - 109842
Опубликована: Янв. 1, 2025
Glutamine
availability
may
be
reduced
in
chronic
diseases,
such
as
type
2
diabetes
mellitus
(T2DM)-induced
by
obesity.
Herein,
the
antioxidant,
anti-inflammatory
and
lipid
metabolism
effects
of
oral
glutamine
supplementation
its
free
dipeptide
form
were
assessed
ob/ob
mice.
Adult
male
C57BL/6J
mice
supplemented
with
L-alanyl-L-glutamine
(DIP)
or
L-glutamine
(GLN)
drinking
water
for
40
days,
whilst
Wild-type
lean
(WT)
control
(CTRL)
received
fresh
only.
Plasma
tissue
(skeletal
muscle
liver)
levels,
insulin
resistance
parameters
(e.g.,
GTT,
ITT,
insulin)
determined.
Oxidative
stress
GSH
system,
Nrf2
translocation),
inflammatory
NFkB
translocation,
TNF-α
gene
expression)
plasma
liver
triglyceride
SRBP-1,
FAS,
ACC,
ChRBP
also
analyzed.
CTRL
showed
lower
levels
tissue,
well
increased
fat
liver.
Conversely,
DIP
restored
tissues,
improved
glucose
homeostasis
levels.
Also,
restoration,
expression
was
observed
group.
Interestingly,
GLN
only
stores
but
overall
resistance,
attenuated
metabolic
biomarkers.
The
results
presented
herein
indicate
that
restoration
body
reduces
oxidative
inflammation
obese
T2DM
This
effect
hepatic
changes
