Yes, Frailty Matters: Time for Action DOI Creative Commons
George Heckman,

Kari Barnard,

Robert S. McKelvie

и другие.

Canadian Journal of Cardiology, Год журнала: 2024, Номер 40(4), С. 685 - 687

Опубликована: Янв. 4, 2024

The global burden of heart failure (HF) is rising around the world, driven—in large part—by population aging and improved survival persons with cardiovascular risk factors.1Savarese G. Becher P.M. Lund L.H. et al.Global failure: a comprehensive updated review epidemiology.Cardiovasc Res. 2023; 118 (Erratum: Cardiovasc Res 2023;119:1453): 3272-3287Crossref PubMed Scopus (475) Google Scholar,2Roger V.L. Epidemiology contemporary perspective.Circ 2021; 128: 1421-1434Crossref (364) Scholar HF remains substantial greatest among older patients, who are more likely to experience acute care, functional cognitive decline, death.1Savarese This demographic shift has also seen emergence frailty as an important factor for poor outcomes in this population.3Butt J.H. Dewan P. Jhund P.S. al.Sacubitril/valsartan patients preserved ejection fraction.J Am Coll Cardiol. 2022; 80: 1130-1143Crossref (29) Scholar, 4Dewan Jackson A. al.The prevalence importance reduced fraction - analysis PARADIGM-HF ATMOSPHERE.Eur J Heart Fail. 2020; 22: 2123-2133Crossref (73) 5Talha K.M. Pandey Fudim M. Butler J. Anker S.D. Khan M.S. Frailty State-of-the-Art Review.J Cachexia Sarcopenia Muscle. 14: 1959-1972Crossref (5) graded clinical state characterized by heightened vulnerability adverse health when exposed stressor resulting from accumulation age physiological deficits across multiple organ systems.6Dent E. Hanlon Sim al.EPI-FRAIL consortium. Recent developments identification, management, factors prevention: narrative leading journals geriatrics gerontology.Ageing Rev. 91102082Crossref (4) At least one-half living may be frail, underuse guideline directed therapies, associated higher rates hospitalization death.3Butt common prognostically significant comorbid led recognition Frail Phenotype 2023 Focused Clinical Practice Update Canadian Cardiovascular Society Failure Society.7Ducharme Zieroth S. Ahooja V. al.Canadian Society-Canadian focused practice update differing phenotypes.Can 39: 1030-1040Abstract Full Text PDF However, guidance on how implement care processes better support frail lacking. In issue Journal Cardiology, Fujimoto al.8Fujimoto Y. Matsue Maeda D. al.Association prognostic value multidomain defined cumulative deficit phenotype models failure.Can 2024; 40: 677-684Abstract (1) present post hoc prospective cohort study 1027 ambulatory aged 65 years older, hospitalized diagnosis regardless left ventricular fraction, recruited 15 hospitals Japan. Patients assist devices, had undergone cardiac transplantation, were long-term dialysis, or diagnosed myocarditis excluded. was assessed 4 ways: physical based Fried phenotype; social alone, going out less frequently compared previous year, not visiting friends sometimes, feeling helpful family, talking someone every day;cognitive Mini-Cog assessment; index (FI) 34 items, including some first 3 measures well other performance, clinical, diagnostic measures.9Fried L.P. Tangen C.M. Walston al.Cardiovascular Health Study Collaborative Research GroupFrailty adults: evidence phenotype.J Gerontol A Biol Sci Med Sci. 2001; 56: M146-M156Crossref 10Makizako H. Shimada Doi T. al.Social leads development physically non-frail four-year follow-up longitudinal study.Int Environ Public Health. 2018; 15: 490Crossref (141) 11Borson Scanlan J.M. Chen Ganguli screen dementia: validation population-based sample.J Geriatr Soc. 2003; 51: 1451-1454Crossref (891) 12Mitnitski A.B. Graham J.E. Mogilner A.J. Rockwood K. Frailty, fitness late-life mortality relation chronological biological age.BMC Geriatr. 2002; 2: 1Crossref (524) median 81 years; 58.1% men mean fractions 46%. FI 0.44, which much than that recent randomized trials. After 2 years, 20% died. emerged independent death beyond conventional factors, hazard ratio 1.21 (95% confidence interval, 1.07-1.37) each 0.1 increase FI. Adding scores accuracy, although no difference shown between effect measures. All correlated one another. Clearly, matters. what we do information? reiterates presence can complicate treatment emphasizes shared decision making individualizing planning. concerns about polypharmacy falls involving pharmacists conduct medication reviews. Involvement dietician, occupational therapist, physiotherapist recommended. these interventions represent limited subset gold standard intervention person frailty, Comprehensive Geriatric Assessment (CGA) delivered specialized geriatric service. context, CGA multidimensional interdisciplinary process assessing persons' medical, psychological, capacity develop coordinated integrated plan (Table 1).13Ho L. Malden McGill al.Complex improving quality life amongst community-dwelling systematic meta-analysis.Age Ageing. 52: afad132Crossref 14Yen P.C. Lo Y.T. Lai C.C. al.Effectiveness outpatient evaluation management nursing home admission: meta-analysis controlled trials.BMC 23: 414Crossref (2) 15Yip K.F. Wong T.H. Alhamid S.M. al.Integrating advance planning part assessment hospitalised elderly patients: findings cross-sectional study.Singapore 61: 254-259Crossref (11) When appropriately targeted, reduce prevent fractures, improve cognition mood, caregiver use services, delay institutionalization.13Ho Scholar,14Yen provide useful information advanced-care planning.15Yip ScholarTable 1Elements Assessment13Ho ScholarComprehensive following domains:•Medical: Diagnoses, review, prevention (immunization, fractures)•Neuropsychiatric: Cognition, anxiety, behaviours, psychosis•Physical function: Instrumental basic activities daily living•Health indicators: Nutrition, sarcopenia, pain, skin integrity•Mobility: Gait balance problems, gait aids, falls•Senses: Hearing, vision•Sociodemographic: Caregiving, socioeconomic, situation, supportsProcedures•Identify patient wishes goals•Develop tailored patient's needs overall identifies mitigate potential stressors•Implementation Open table new tab binary "to treat treat" indicator nor it absolute contraindication guideline-directed medical therapy. Although at increased side effects suggests that, many, greater stems undertreatment, even frailty.3Butt Evidence does suggest will benefit disease-management setting doses carefully titrated upward, their partners receive ongoing support.16Pulignano Del Sindaco Di Lenarda al.Usefulness profile targeting disease programs: cost-effectiveness, pilot study.J (Hagerstown). 2010; 11: 739-747Crossref (86) Moreover, close integration primary essential requires coordination different providers responsive evolving throughout journey.17Heckman G.A. Integrated elderly.Healthc Pap. 2011; 11 (discussion 86-91): 62-68Crossref (16) Scholar,18Heckman Hillier Manderson B. McKinnon-Wilson Santi Stolee Developing system seniors.Healthc Manage Forum. 2013; 26: 200-208Abstract (21) achieved through "spoke-hub-node" organization whereby services specialties collaborate closely sector resourced community-based multidisciplinary teams.19Huitema A.A. Harkness Heckman McKelvie R.S. Spoke-hub-and-node model care.Can 34: 863-870Abstract (24) By its very nature, complex time-consuming intervention, system-wide strategy efficient approach case-finding resources those most benefit. methods used assess time intensive too unwieldy impractical implementation into routine under-resourced systems. classify differently, would greatly standards.20Heckman Turcotte Hirdes J.P. crying need validated consensus measurement standards: real please stand up?.Can 37: 1702-1704Abstract Scholar,21Rolfson D.B. Bagshaw Robertson Implementing healthcare system.J Aging. 7: 208-216PubMed identified interRAI instruments foundation upon such system.21Rolfson Designed international nonprofit scientific consortium, systems already widespread Canada many countries. They include brief electronic self-report adults, thus minimizing providers. addition facilitating informational sectors, facilitate comparisons characteristics, indicators, provinces, internationally.22Sinn C.J. Poss J.W. Boscart V.M. Implementation stepped using Ontario, Canada.Health Soc Care Community. 30: 2341-2352Crossref (6) 23Heckman Gimbel Morrison al.Preliminary shared-care, care-based interprofessional program community. Abstracts 42nd Annual Scientific Meeting Geriatrics Society: Compassionate all: renewing our passion, recalibrating compass; April 13-15, Vancouver, British Columbia.Can 290-325PubMed 24Heckman Gray L.C. Addressing seniors Canada: role instruments.CGS CME. 3: 8-16Google add body literature HF. It now act data. To best growing HF, imperative able efficiently identify, assess, concurrent frailty. Optimizing both meeting broader reliance acute-care allow successfully home. authors wish thank Chantelle Mensink comments unpublished letter editor similar topic. Dr supported Schlegel Chair Medicine.

Язык: Английский

Delirium and frailty in older adults: Clinical overlap and biological underpinnings DOI Creative Commons
Giuseppe Bellelli, Federico Triolo, María Cristina Ferrara

и другие.

Journal of Internal Medicine, Год журнала: 2024, Номер 296(5), С. 382 - 398

Опубликована: Окт. 1, 2024

Frailty and delirium are two common geriatric syndromes sharing several clinical characteristics, risk factors, negative outcomes. Understanding their interdependency is crucial to identify shared mechanisms implement initiatives reduce the associated burden. This literature review summarizes scientific evidence on complex interplay between frailty delirium; clinical, epidemiological, pathophysiological commonalities; current knowledge gaps. We conducted a PubMed systematic search in June 2023, which yielded 118 eligible articles out of 991. The synthesis results-carried by content experts-highlights overlapping phenotypes, outcomes explores influence one syndrome onset other. Common identified include inflammation, neurodegeneration, metabolic insufficiency, vascular suggests that factor for delirium, with some support accelerated frailty. proposed unifying framework supports integration measurement both constructs research practice, identifying geroscience approach as potential avenue develop strategies conditions. In conclusion, we suggest might be alternative-sometimes coexisting-manifestations biological aging. Clinically, concepts addressed this can help older adults either or from different perspective. From standpoint, longitudinal studies needed explore hypothesis specific pathways within biology aging may underlie manifestations delirium. Such will pave way future understanding other well.

Язык: Английский

Процитировано

8

Association between physical activity and frailty transitions in middle-aged and older adults: a nationwide longitudinal study DOI Creative Commons

Li Huang,

Zhenzhen Liang, Huajian Chen

и другие.

International Journal of Behavioral Nutrition and Physical Activity, Год журнала: 2025, Номер 22(1)

Опубликована: Март 10, 2025

Abstract Background Frailty has become an important health problem in the middle-aged and older people population. Physical activity (PA) is a key intervention for frailty prevention management. However, studies of association between COVID-19 pre-pandemic PA worsening or improvement during pandemic remain unclear. Methods This longitudinal cohort study used data from English Longitudinal Study Ageing (ELSA), including participants aged 50 over. Three intensities (vigorous, moderate, mild) were categorized as less than once per week at least week, respectively, based on participant self-report. The index (FI) assessed status, defining FI ≥ 25. Logistic regression was applied to examine frailty, estimating odds ratios (OR) 95% confidence intervals (95% CI). Results Of 4379 non-frail baseline (median age 67, 54.9% female), 8.1% developed mean follow-up 3.5 years. Among 564 frail 71, 66.5% 17.9% regained health. Compared those engaging who engaged vigorous (OR: 0.47 [95% CI: 0.35–0.62]), moderate 0.37 0.29–0.48]), mild 0.38 0.26–0.56]) had lower risk worsening. Additionally, 2.04 1.29–3.21]) 2.93 1.54–5.58]) higher likelihood improvement. Sensitivity analyses comprehensive levels confirmed these findings. Participants maintained one (Vigorous, OR: 0.20 [95%CI: 0.12–0.33]; Moderate, 0.13 0.09–0.19]; Mild, 0.11–0.38]) rates (Moderate, 3.43 1.93–6.11]; 4.65 1.90-11.42]). In addition, individuals 0.35 0.20–0.60]; 0.36 0.22–0.56]) transitioned inactive active also exhibited frailty. Conclusions emphasized critical role preventing improving people, especially pandemic. Our highlighted importance maintaining habits reduce promote its Also, indicated that These findings enriched understanding provided valuable insights addressing impact future pandemics people.

Язык: Английский

Процитировано

1

Association Between Frailty and Subjective Life Expectancy in Sub-Saharan Africa: Evidence from Cote D'Ivoire DOI
Gideon Dzando, Richard K. Moussa

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 131, С. 105757 - 105757

Опубликована: Янв. 10, 2025

Язык: Английский

Процитировано

0

Age Self Care-Resilience, a medical group visit program targeting pre-frailty: A mixed methods pilot clinical trial DOI Creative Commons
Julia Loewenthal, Wren Burton,

SH Kamali

и другие.

The Journal of Frailty & Aging, Год журнала: 2025, Номер 14(1), С. 100005 - 100005

Опубликована: Янв. 22, 2025

Pre-frailty is highly prevalent and multimodal lifestyle interventions are effective for preventing transition to frailty. However, little known about the potential medical group visits (MGV) prevent frailty progression. To assess feasibility acceptability of MGV Age Self Care-Resilience. Single-arm mixed methods pilot clinical trial. Virtual delivered in an ambulatory setting at a U.S. academic center. Community-dwelling older adults (n = 11; age 65+) with pre- mild Care-Resilience, 8-week virtual (90-minute sessions once per week) focused on physical activity, nutrition, social engagement, mind-body practice, home environment modification. Primary outcomes were recruitment, attendance, satisfaction, study measurements, collected via quantitative qualitative approaches. Exploratory included frailty, psychosocial health, function. A priori criteria met 15 (48 %) those screened (31) meeting eligibility criteria, 11 (35 enrolling (mean 74.5 yrs), recruitment completed less than one month. The nine participants who attended mean 7.2 8 100 % baseline follow-up measures; 58 practice log. Themes from participant interviews included: (1) reactions term "pre-frailty;" (2) finding participation as meaningful empowering; (3) perception that program positively changed attitudes behaviors. Care-Resilience feasible acceptable mildly frail adults. Next steps include evaluating efficacy progression fully powered randomized controlled

Язык: Английский

Процитировано

0

The PROAGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department DOI Open Access
Inessa Cohen, Pedro Kallas Curiati, Christian Valle Morinaga

и другие.

Journal of the American Geriatrics Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

ABSTRACT Background Existing risk scores assessing geriatric vulnerability in the emergency department (ED) have shown limited predictive power, especially diverse populations. We investigated relationship of a quick and easy‐to‐administer scoring system with functional decline mortality older patients admitted to multiple hospitals through ED United States (US) Brazil (BR). Method Federated, international, multicenter observational study hospitalized aged ≥ 65 from US BR. The six criteria PRO‐AGE score (Physical impairment, Recent hospitalization, Older age [≥ 90], Acute mental alteration, Getting thinner, Exhaustion; 0–8; higher = greater vulnerability) were assessed on admission. used proportional hazards models investigate relationships between groups 90‐day decline, defined as new dependence activities daily living (ADL) instrumental ADL (IADL), after adjusting for age, sex, race ethnicity, education, Charlson comorbidity score, site. Death was considered competing event outcome. Results A total 1390 included (US 560; 830). death upper compared lower (reference) group both cohorts (US: HR 11.76; 95% confidence interval [CI] 2.56–54.04; BR: 12.29; CI 3.54–42.59), whereas disability (HR 2.08; 1.21–3.56) middle 2.10; 1.35–3.27) but only BR 1.70; 1.02–2.85). Conclusion associated BR, demonstrating its generalizability score.

Язык: Английский

Процитировано

0

Global burden of injury due to low bone mineral density in adults aged 55 years and older, 1990 to 2021: A population-based study DOI
Jiansheng Wang, Shaoting Luo,

Fuxi Wang

и другие.

Bone, Год журнала: 2025, Номер unknown, С. 117418 - 117418

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Battling Frailty in Older Adults DOI

Pam LaBorde,

Melodee Harris

Advances in Family Practice Nursing, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Процитировано

0

Referral to Geriatric Rehabilitation in the Netherlands, an Exploratory Study of Patient Characteristics DOI

Aafke J. de Groot,

E. Wattel, Romke van Balen

и другие.

Rehabilitation Nursing, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Purpose Geriatric rehabilitation is intended for older adults with vulnerability, comorbidity, and acute functional impairments. To explore evaluate referral criteria, this study followed hospital patients referred in nursing homes. Design Exploratory, retrospective cohort study. Methods Participants were community living before hospitalization geriatric between January 15 May 15, 2019. Data collected at admission, discharge, discharge from rehabilitation-oriented care. Outcome measure was the final destination. Results Out of 87 (mean age = 76.3 years, SD 10.7), 73 received post-acute care 60 (82.2%) returned home after rehabilitation. Premorbid status regained by 45 (61.6%) participants mobility 40 (54.8%). Independent baseline mobility, no complications during care, fewer cognitive symptoms, multidomain vulnerability associated destination Clinical Relevance to Rehabilitation Nursing A assessment can make applicable decisions induce tailored individual programs. Conclusion This explored case-mix characteristics following trajectories. No frailty measures available; refined into physical, cognitive, social components. Careful support personalized decision-making.

Язык: Английский

Процитировано

0

State of the Art in Measuring Frailty in Patients With Heart Failure: from Diagnosis to Advanced Heart Failure DOI Creative Commons
Izabella Uchmanowicz, Magdalena Lisiak, Katarzyna Lomper

и другие.

Current Heart Failure Reports, Год журнала: 2025, Номер 22(1)

Опубликована: Март 8, 2025

This review aims to present the current state of art in measuring frailty patients with heart failure (HF), covering entire spectrum from diagnosis advanced stages disease. Frailty is a critical factor that significantly impacts outcomes failure, and accurate assessment essential for guiding treatment improving prognosis. increasingly recognized as key determinant morbidity mortality HF patients. Various tools are available assessing frailty, but there no consensus on optimal method. The needs be multidimensional, incorporating physical, cognitive, social domains. Early detection coupled personalized interventions, has potential improve patient outcomes. Integrating routine assessments into clinical care optimizing treatment. Future research should focus standardizing integrating innovative technologies, such artificial intelligence, enhance precision applicability these practice.

Язык: Английский

Процитировано

0

Knowledge, attitude, and practice of frailty management among clinical nurses: a cross-sectional study DOI Creative Commons
Xueyan Huang, Haifang Zhou, Ying Feng

и другие.

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 14, 2025

Frailty is a leading risk factor of falls, incapacitation, functional decline, and even death in aging populations globally. Clinical nurses play pivotal roles screening, prevention, intervention to reverse or slow the progression frailty. The present study aimed (1) understand extent influencing factors knowledge, attitudes, practices clinical for managing frailty, (2) elucidate relationships frailty management. This cross-sectional was conducted from March April 2024 on 524 tertiary hospital Zhejiang Province, China. survey instruments included questionnaire inquiring about terms management, demographic data form, self-designed educational information questionnaire. Data were analyzed by descriptive statistics, univariate analysis, multiple linear regression, structural equation modeling. Of nurses, Only 37.2% rated as good attitude, practice while 55.7% moderate. Among them, proportion with knowledge (10.3%) practical skills (13.4%) much lower than their attitude (65.3%). Structural modeling found that attitudes related management practices, significant associations between practices(β = 0.499, p < 0.001). total effect size (total 0.624, 95% CI: 0.455,0.791), approximately 20.0% mediated (indirect 0.125, 0.076,0.187). Multiple regression analysis showed age, organizational support, familiarity relevant guidelines, familiar term department all had score(adjusted R2 0.264, Despite inadequate limited experience nurses' towards positive, indicating potential improvement. model useful explain thereby providing theoretical basis development targeted training programs. Not applicable.

Язык: Английский

Процитировано

0