Medical Hypotheses, Год журнала: 2024, Номер unknown, С. 111555 - 111555
Опубликована: Дек. 1, 2024
Язык: Английский
The journal of nutrition health & aging, Год журнала: 2025, Номер 29(4), С. 100505 - 100505
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
1
GeroScience, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
7
ACS Omega, Год журнала: 2024, Номер 9(12), С. 14316 - 14322
Опубликована: Март 14, 2024
Inflammatory bowel disease (IBD) is a serious public health issue because of its chronic and incurable nature. Common IBD drugs have limited efficacy produce adverse effects, leading to an urgent need develop new drug delivery systems. Curcumin (Cur) natural nontoxic that increasingly used in the treatment owing anti-inflammatory antioxidant effects. Metal–polyphenol networks constructed from metal ions polyphenols exhibit biological functionality while acting as adhesive nanomaterial encapsulate nano-Cur, thereby improving solubility release behavior. In this study, we prepared Cur@Fe&TA nanodrug system by constructing Fe3+/tannic acid (TA) metal–polyphenol network with encapsulated Cur. The exhibited good stability, behavior, biocompatibility. Based on effects Cur@Fe&TA, gastrointestinal cytopathology mouse model was effectively improved. proposed nanomedicine has promising application research value for regulating levels antioxidants inflammatory cytokines.
Язык: Английский
Процитировано
5
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3431 - 3447
Опубликована: Март 1, 2025
Background: Cellular senescence, a hallmark of aging, significantly contributes to the pathology ulcerative colitis (UC). Despite this, role senescence-related genes in UC remains largely undefined. This study seeks clarify impact cellular senescence on by identifying key and developing diagnostic models with potential clinical utility. Methods: Clinical data gene expression profiles were obtained from Gene Expression Omnibus (GEO) database. Senescence-related differentially expressed (sene-DEGs) between patients healthy controls identified using various bioinformatics techniques. Functional enrichment immune infiltration analyses performed understand subtype characteristics derived sene-DEGs through consensus clustering. Machine learning algorithms employed select feature sene-DEGs, their was validated across multiple independent datasets human specimens. A nomogram incorporating these created assessed, its performance evaluated receiver operating characteristic (ROC) analysis datasets. Results: Fourteen differential controls. These enabled classification into molecular subtypes via unsupervised ABCB1 LCN2 emerged as central hub machine importance analysis. ROC verified value Validation specimens supported findings. Furthermore, levels showed significant associations cell profiles. The logistic regression (LR) model based demonstrated accurate prediction, confirmed curve model, constructed genes, exhibited outstanding prediction capabilities, DCA, C index, calibration assessments. Conclusion: integrated approach biomarkers associated senescence. findings enhance understanding pathogenesis propose valuable biomarker. Keywords: colitis, biomarkers,
Язык: Английский
Процитировано
0
Advances in pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142368 - 142368
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nutrition, Год журнала: 2025, Номер unknown, С. 112800 - 112800
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5904 - 5904
Опубликована: Май 28, 2024
For the past 70 years, dopamine hypothesis has been key working model in schizophrenia. This contributed to development of numerous inhibitors dopaminergic signaling and antipsychotic drugs, which led rapid symptom resolution but only marginal outcome improvement. Over decades, there limited research on quantifiable pathological changes schizophrenia, including premature cellular/neuronal senescence, brain volume loss, attenuation gamma oscillations electroencephalograms, oxidation lipids plasma mitochondrial membranes. We surmise that aberrant activation aryl hydrocarbon receptor by toxins derived from gut microbes or environment drives cellular neuronal a hallmark Early aging promotes secondary changes, impairment loss mitochondria, gray matter depletion, decreased oscillations, compensatory metabolic shift lactate lactylation. The aim this narrative review is twofold: (1) summarize what known about senescence schizophrenia schizophrenia-like disorders, (2) discuss novel strategies for improving long-term outcomes severe mental illness with natural senotherapeutics, membrane lipid replacement, transplantation, microbial phenazines, antioxidant phenothiazines, glycogen synthase kinase-3 beta, antagonists.
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Ноя. 15, 2024
Ulcerative Colitis (UC) is an inflammatory disorder characterized by chronic intestinal inflammation and immune dysregulation. Despite a clear association between cellular senescence dysregulation, the mechanisms underlying in UC remain unclear. We screened differentially expressed genes (DEGs) associated with multiple datasets, performed infiltration analysis, constructed clinical diagnostic models. Additionally, we investigated relationship key related to disease remission patients undergoing biologic therapy, validating their expression single-cell dataset. identified six DEGs (TWIST1, IGFBP5, MME, IFNG, ME1, FOS). Immune results indicated strong correlations of four these cells pathways. Through WGCNA, GO, KEGG analyses, found that gene modules strongly hub were enriched inflammation-related In dataset, exhibited similarities results. nomogram using for diagnosing UC, demonstrating good capability efficacy. Kaplan–Meier survival analysis revealed significant changes levels cell therapy. This study utilizes bioinformatic machine learning identify analyze features datasets. It provides insights into role premature onset aging offers new perspectives exploring novel therapeutic targets.
Язык: Английский
Процитировано
2
Опубликована: Март 28, 2024
Abstract For the past 70 years, dopamine hypothesis has been key working model in schizophrenia. This contributed to development of numerous inhibitors dopaminergic signaling, antipsychotic drugs, which led rapid symptom resolution but only marginal outcome improvement. Over decades, there was limited research on quantifiable pathological changes schizophrenia, including premature cellular/neuronal, senescence, brain volume loss, attenuation gamma oscillations electroencephalogram and oxidation lipids plasma mitochondrial membranes. We surmise that aberrant activation aryl hydrocarbon receptor by toxins derived from gut microbes or environment drives cellular, neuronal, a hallmark Early aging promotes secondary changes, impairment loss mitochondria, gray matter depletion, decreased oscillations, compensatory metabolic shift lactate lactylation. The aim this narrative review is twofold: 1. To summarize what known about cellular/neuronal senescence schizophrenia schizophrenia-like disorders. 2. discuss novel strategies for improving long-term severe mental illness with natural senotherapeutics, membrane lipid replacement, transplantation, microbial phenazines, antioxidant phenothiazines, glycogen synthase kinase-3 beta, receptor.
Язык: Английский
Процитировано
0