Future Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Дек. 10, 2024
Pterostilbene
(PT)
is
a
naturally
occurring
small
molecule
stilbenoid
that
has
garnered
significant
attention
due
to
its
potential
therapeutic
effects
in
tumor
diseases.
In
this
review,
we
conducted
comprehensive
analysis
of
the
antitumor
PT
and
derivatives
on
various
cancer
types,
including
colon,
breast,
liver,
lung,
pancreatic
cancers
recent
20
years.
We
have
succinctly
summarized
exhibit
superior
anti-tumor
efficacy
compared
PT.
Additionally,
reviewed
structure-activity
relationship
(SAR)
rules
clinical
application
methods
establish
foundation
for
chemical
modification
utilization
stilbene
compounds.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
279, С. 116461 - 116461
Опубликована: Май 19, 2024
Polystyrene
nanoplastics
(PS-NPs)
have
been
reported
to
accumulate
in
the
testes
and
constitute
a
new
threat
reproductive
health.
However,
exact
effects
of
PS-NPs
exposure
on
testicular
cells
underlying
mechanisms
remain
largely
unknown.
The
C57BL/6
male
mice
were
orally
administered
with
(80
nm)
at
different
dosages
(0,
10,
40
mg/kg/day)
for
60
days,
GC-1
treated
this
study.
Enlarged
seminiferous
tubule
lumens
loose
vacuolated
layer
spermatogenic
observed
PS-NPs-exposed
mice.
Spermatogenic
which
may
be
one
target
damage,
decreased
from
group.
caused
undergo
senescence,
manifested
as
elevated
SA-β-galactosidase
activity
activated
senescence-related
signaling
p53-p21/Rb-p16
pathways,
induced
cell
cycle
arrest.
Mechanistically,
Gene
Ontology
(GO)
enrichment
suggested
key
role
reactive
oxygen
species
(ROS)
PS-NPs-induced
result
was
confirmed
by
measuring
ROS
levels.
Moreover,
inhibition
partially
attenuated
senescence
phenotype
DNA
damage.
Using
health
atlas
(MHA)
database,
Sirt1
filtrated
critical
molecule
regulation
senescence.
overexpression
main
generator
Nox2,
downregulated
Sirt1,
increased
p53
acetylated
vivo
vitro,
whereas
these
disturbances
restored
pterostilbene.
In
addition,
pterostilbene
intervention
significantly
alleviated
burst.
Collectively,
our
study
reveals
that
can
trigger
mediated
regulating
Sirt1/ROS
axis.
Importantly,
promising
strategy
alleviate
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(9)
Опубликована: Июнь 20, 2024
Abstract
A
series
of
resveratrol
surrogate
molecules
were
designed,
synthesized
and
biologically
evaluated
for
inhibition
acetylcholinesterase
(AChE)
butyrylcholinesterase
(BChE)
along
with
anti‐oxidant
activity
as
potential
novel
multifunctional
agents
against
Alzheimer's
disease
(AD).
Six
compounds
by
reacting
(E)‐4‐(3,5‐Dimethoxystyryl)
aniline
benzaldehyde
some
selected
derivatives
in
the
presence
ethanol
a
few
drops
glacial
acetic
acid
which
followed
general
scheme
involved
formation
Schiff
bases.
The
spectral
analysis
data
including
FT‐IR,
1
H‐NMR,
13
C‐NMR,
Mass
spectroscopy
results
found
to
be
good
agreement
newly
(Resveratrol
Surrogate
Molecules
1–6).
their
dual
cholinesterase
inhibitory
activities,
cytotoxic
effect,
potential.
showed
that
compound
RSM5
potent
AChE
BChE.
In,
addition
cytotoxicity
is
less
within
desirable
limit
indicating
safety
RSM5.
Also,
it
possesses
substantial
qualifies
an
anti‐AD
agent.
Taken
together,
these
findings
demonstrate
molecule
had
most
properties
could
promising
lead
future
development
drugs
treatments.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 7, 2024
This
study
reviews
the
development
of
rhubarb
processing
and
current
status
pharmacological
research.
We
summarized
effects
different
methods
on
active
compounds,
effects,
toxicity
rhubarb,
as
well
clinical
application
concoctions,
providing
reference
for
further
research
rhubarb.
Toxicology Research,
Год журнала:
2024,
Номер
13(3)
Опубликована: Май 1, 2024
Abstract
Introduction:
The
rapid
development
of
nanotechnologies
with
their
widespread
prosperities
has
advanced
concerns
regarding
potential
health
hazards
the
Nanoparticles.
Results:
Nanoparticles
are
currently
present
in
several
consumer
products,
including
medications,
food,
textiles,
sports
equipment,
and
electrical
components.
Despite
advantages
Nanoparticles,
toxicity
negative
impact
on
human
health,
particularly
reproductive
health.
Conclusions:
various
NPs
system
function
is
yet
to
be
determined.
Additional
research
required
study
primary
objective
this
review
unravel
toxic
effects
different
functions
recent
investigations
both
vitro
vivo.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 122 - 122
Опубликована: Дек. 26, 2024
One
of
the
most
pressing
challenges
facing
society
today
is
rising
prevalence
physical
and
cognitive
frailty.
This
geriatric
condition
makes
older
adults
more
vulnerable
to
disability,
illness,
a
heightened
risk
mortality.
In
this
scenario,
Parkinson’s
disease
(PD)
frailty,
which
share
several
common
characteristics,
are
becoming
increasingly
prevalent
worldwide,
underscoring
urgent
need
for
innovative
strategies.
Nutraceuticals
naturally
occurring
bioactive
compounds
contained
in
foods,
offering
health
benefits
over
above
essential
nutrition.
By
examining
literature
from
past
decade,
review
highlights
how
nutraceuticals
can
act
as
complementary
therapies,
addressing
key
processes,
such
oxidative
stress,
inflammation,
neuroprotection.
Notably,
antioxidant
action
appears
particularly
beneficial
regard
PD
For
instance,
antioxidant-rich
may
mitigate
damage
linked
levodopa
therapy
PD,
potentially
reducing
side
effects
enhancing
treatment
sustainability.
Similarly,
amplify
activity,
muscle
function,
health,
resilience,
thereby
proposes
holistic
approach
integrating
with
exercise,
pharmacotherapy,
lifestyle
adjustments.
It
promises
transform
management
ARD,
prolong
life,
improve
quality
life
well-being
people.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 1, 2024
Herbal
medicines
(HMs)
have
long
played
a
pivotal
role
in
preventing
and
treating
various
human
diseases
been
studied
widely.
However,
the
complexities
present
HM
metabolites
their
unclear
mechanisms
of
action
posed
significant
challenges
modernization
traditional
Chinese
medicine
(TCM).
Over
past
two
decades,
mass
spectrometry
imaging
(MSI)
has
garnered
increasing
attention
as
robust
analytical
technique
that
enables
simultaneous
execution
qualitative,
quantitative,
localization
analyses
without
complex
sample
pretreatment.
With
advances
technical
solutions,
MSI
extensively
applied
field
HMs.
MSI,
label-free
ion
can
comprehensively
map
spatial
distribution
plant
native
tissues,
thereby
facilitating
effective
quality
control
Furthermore,
dimension
information
small
molecule
endogenous
within
animal
tissues
provided
by
also
serve
supplement
to
uncover
pharmacological
toxicological
In
review,
we
provide
an
overview
three
most
common
techniques.
addition,
representative
applications
are
highlighted.
Finally,
discuss
current
propose
several
potential
solutions.
We
hope
summary
recent
findings
will
contribute
application
exploring
