Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Creative Commons
Roy A.M. Haast, Jason Kai, Alaa Taha

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Abstract The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Язык: Английский

The expression of transcription factors in the human fetal subthalamic nucleus suggests its origin from the first hypothalamic prosomere DOI Creative Commons
Ema Bokulić, Tila Medenica, Mihaela Bobić‐Rasonja

и другие.

Brain Structure and Function, Год журнала: 2025, Номер 230(2)

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

1
Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress DOI
Si-Hai Chen, Bo Lan, Yingying Zhang

и другие.

World Journal of Psychiatry, Год журнала: 2025, Номер 15(2)

Опубликована: Янв. 14, 2025

BACKGROUND Depression is a prevalent affective disorder, but its pathophysiology remains unclear. Dysfunction in the gamma-aminobutyric acid (GABA)-ergic system may contribute to onset. Recently, antidepressants (e.g., brexanolone, zuranolone) targeting GABA-A receptor were introduced. The zona incerta (ZI), an inhibitory subthalamic region mainly composed of GABAergic neurons, has been implicated emotional regulation. Deep brain stimulation ZI humans affects anxiety and depression symptoms, while activation neurons mice can either worsen or alleviate anxiety. Currently, there no direct evidence linking depression-like behaviors rodents. AIM To explore relationship between mice. METHODS A chronic restraint stress (CRS) model was utilized induce Whole-cell patch-clamp recordings assessed excitability changes ZI. Additionally, chemogenetic techniques employed modulate neurons. performance behavioral tests for observed. RESULTS findings indicated that closely associated with Twenty-eight days after CRS established, anxiety-like observed reduced. Chemogenetic these alleviated CRS-induced behaviors. Conversely, inhibition led emotion-related outcomes CONCLUSION Activity phenotypes mice, suggesting could be potential therapeutic target treating depression.

Язык: Английский

Процитировано

0
Abnormal iron metabolism in the zona incerta in Parkinson’s disease mice DOI

Minxia Xiu,

Yanhong Liu, Zhaobo Wang

и другие.

Journal of Neural Transmission, Год журнала: 2025, Номер unknown

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

0
Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments DOI Creative Commons
Francesco Ceccarelli, Fabrizio Londei,

Giulia Arena

и другие.

Animals, Год журнала: 2025, Номер 15(9), С. 1340 - 1340

Опубликована: Май 6, 2025

Research involving non-human primates remains a cornerstone in fields such as biomedical research and systems neuroscience. However, the daily routines of laboratory work can induce stress these animals, potentially compromising their well-being reliability experimental outcomes. To address this, many laboratories have adopted home-cage training protocols to mitigate caused by routine procedures transport restraint—a factor that impact both macaque physiology validity. This review explores primary methods setups employed training, highlighting potential not only ethical concerns surrounding animal welfare but also reduce time risks for researchers. Furthermore, combining with wireless recordings, it becomes possible expand opportunities behavioral neurophysiology primates. approach enables study various cognitive processes more naturalistic settings, thereby increasing ecological validity scientific findings through innovative designs thoroughly investigate complexity animals’ natural behavior.

Язык: Английский

Процитировано

0
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Open Access
Roy A.M. Haast, Jason Kai, Alaa Taha

и другие.

Опубликована: Фев. 3, 2025

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Язык: Английский

Процитировано

0
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Open Access
Roy A.M. Haast, Jason Kai, Alaa Taha

и другие.

Опубликована: Фев. 3, 2025

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Язык: Английский

Процитировано

0
Zona incerta: from Parkinson's disease to addiction DOI Creative Commons

Marcia A. Wilt,

Robin Magnard, Sébastien Carnicella

и другие.

Frontiers in Neural Circuits, Год журнала: 2025, Номер 19

Опубликована: Фев. 6, 2025

The zona incerta (ZI), a small and historically overlooked structure located beneath the thalamus, has been increasingly recognized for its role in diverse behavioral processes. Early studies 1970s 1980s explored ingestive behaviors, including drinking feeding (for review, see (Mitrofanis, 2005))(Figure 1a), suggesting involvement motivation survival mechanisms related to food water intake. ZI is now known be heterogeneous nucleus, divided into four major sectors: rostral (ZIr), dorsal (ZId), ventral (ZIv), caudal (ZIc) 2005), each with distinct neurochemical profiles. GABAergic cells, which constitute majority of ZI's neurons, parvalbumin positive neurons are mostly concentrated ZIv, while ZId rich glutamatergic ZIr contains dopaminergic 2005).While motor functions were identified as early 60s (Hyde Toczek, 1962), focus really shifted on those motor-related roles 1990s, became studied context Parkinson's disease (PD) (Shi et al., 2024). introduction deep brain stimulation (DBS) treatment PD patients, subthalamic nucleus (STN) primary target (Benabid 2009), revealed that stimulating nearby also produced significant improvements symptoms (Voges 2002) (Ossowska, 2020). This led renewed interest ZI, placing it spotlight movement disorder therapies. Consequently, non-motor functions, particularly potential reward processes driving behaviors previously characterized, received less attention. However, reports effects following patients-especially mood (Stefurak 2003) , (Tommasi 2008), or emotion (Burrows 2012)-suggested broader ZI. Notably, motivational alterations such apathy (Czernecki, 2005) (Ricciardi 2014) drew attention processes.Today, there link between motivation. contemporary approaches map, monitor manipulate neural circuits improving our understanding contribution different subregions neuronal populations constituting various functions. shares remarkable similarities substantia nigra pars compacta (SNc) tegmental area (VTA), terms their specific involvements behavior (Morales Margolis, 2017). While VTA, more recently SNc, intensively investigated motivation-related pathologies, especially addiction, this aspect remains largely unexamined. Addiction chronic psychiatric defined by loss control over drug intake, despite negative consequences. It involves recurrent periods seeking, withdrawal relapse, leading spiraling addiction cycle (Koob Le Moal, 2008) Volkow, 2010). Recent findings raise new questions about behaviors. short essay examines current evidence disorders akin highlights future research directions.While underexplored, pharmacological support responsiveness drugs abuse. In situ alcohol injection elicits strong responses (Wayner 1975), injections tetrahydropapaveroline, used initiate consumption rats when injected mesocorticolimbic pathway, induces preference (Myers Privette, 1989). Cocaine intake impacts well, increasing Fos expression (Zahm 2010) reducing neurotensin binding, paralleling pathways (Pilotte 1991). Furthermore, morphine tyrosine hydroxylase enhances dopamine (DA) metabolism implicating modulation (Molnar 1994). These indicate abuse directly impact activity, supporting relevance research.The critical features VTA SNc. A first notable parallel 3 structures presence neurons. Dopaminergic transmission from SNc instrumental at core disorders. All trigger DA release striatum, accumbens (NAc) (Di Chiara Imperato, 1988), signaling values valence biologically relevant stimuli (Bromberg-Martin (Schultz, 1998), but encoding prediction errors (RPE) guide learning (Hollerman Schultz, 1998) making mesolimbic nigrostriatal fundamental motivated (Berke, 2018). Alterations these contribute addiction-like excessive seeking taking (Keiflin Janak, 2015) (Goutaudier 2023) (Giuliano 2019) 1997). Very few have focused (ZIDA), recent suggest pivotal (Ye 2023), Specifically, ZIDA overactive during energy deficit, promoting food-seeking maintaining behavior, partly through projections paraventrical thalamus (PVT) 2023). Moreover, seem involved other appetitive self grooming (Jiang Increased observed abstinence, reflecting sociability impairments models (Lalanne 2017) (Homberg stereotypical induced psychostimulants exacerbated drug-sensitization (Kalueff 2016). Excessive marker compulsivity rodent obsessivecompulsive (Mondragón-González consistent connectivity data both human non-human primates highlighted treating obsessive-compulsive (ICDs) (Haber 2023).In addition well-studied contain substantial populations, another feature common Similar (Zhou 2022) (Lowes 2021), (ZIGABA) regulate project NAc (Wang Their optogenetic shown provoke binge-like eating mice, ablation decreases long-term, reduction body weight result (Zhang Van Den Pol, Other types involve ZIGABA, example hunting (Zhao 2019), novelty (Monosov (Ogasawara 2022), trait particular field an endophenotype vulnerability, predicting transition controlled compulsive cocaine use (Belin Deroche-Gamonet, 2012). Optogenetic activation ZIGABA favor exploration objects conspecifics (Ahmadlou 2021). As NAc-projecting undergo activity changes synaptic plasticity exposure (Friend 2021) (Williams 2018), motivation(Ting-A-Kee 2013) (Elum 2024) (Merkel 2024), one can hypothesize neuroadaptations within ZIGABA-NAc circuit may similarly underlie aspects drug-seeking notably disinhibition exploratory toward novel elements environment.Collectively, exposed above highlight point out reinforcement drives phases eventually leads later marked abstinence individuals experience dysphoria, apathy, anxiety, depression pain. likely craving, process whereby sought consumed alleviate affect experienced 1997) (Robbins Beyond motivation, reminiscent state, anxiety (Li pain (Lu implicated aversive connections amygdala thalamic periaqueductal grey (Chou 2018) (Venkataraman Thus, multifaceted posit contributor addiction.Taken together, all withdrawal-related drug-seeking, become evident positioning canonical (Lüscher 2021)(Figure 1b). structural two circuits. bidirectionally connected and, lesser extent, projects NAc, ideally situated modulate midbrain striatum (Arena mentioned above, PVT key player receives inputs prefrontal cortex lateral hypothalamus (Iglesias Flagel, Zhu, 2019). do not provide input 2014), could play modulatory role, linking homeostatic reward-driven processes, modulating indirectly. aligns decrease striatal after electrolytic lesion (Walker Finally, several nuclei cortex, amygdala, habenula (Figure strategically positioned numerous processes.Overall, clear still emerging, addiction-related circuits, pathways, emotion, interoception, theoretical addiction. potentially recapitulating certain extent some VTA/SNc obviously argument underpinning opinion precise discussed, others found no alteration manipulating cell population, limited prehensile (Garau stark contrast place instance. seems widely accepted, distinction GABA must however put perspective, purely co-express neurotransmission markers (Negishi considerations, remain unanswered: Does induce ZI? encode RPE well? Do adaptations drive escalation, symptoms, seeking? Investigating clarify therapeutic relevance. intersection offers intriguing perspectives, only disorders, clinical ICDs, gambling, hypersexuality, eating, prevalent (Houeto 2016) (Leclercq Corvol, resume most psychobiological (Vassileva Conrod, They attributed replacement therapy 2016), pathological underpinnings fully characterized (Prange Thobois, might ZIDA. Interestingly, L-DOPA parkinsonian (Cole 1993) (Bastide hypothesis.ICDs globally well alleviated STN-DBS patients (Scherrer Given anatomical proximity STN suppression ZI-DBS (Mallet 2002), benefit DBS applied neurological (Vorspan (Pelloux Baunez, 2013), considering ICDs (Potenza, emerge avenue addictions. side associated 2020) need investigations delineate sectors optimize strategies.Figure 1: Zona Incerta interest's evolution, function addiction? (A) Evolution topics publications (ZI) 1965 2024. Data obtained bibliometric analysis scientific literature PubMed, articles "zona incerta" title ; primarily tracing, anatomy, cytoarchitecture, neurodevelopment excluded, even if they referenced (n = 213 articles). Bars represent number per decade, main functional thematic categories: (light blue), (medium deep-brain (dark (orange), threat stress-related (green), somatosensory (red), sexual hormones (pink), (yellow), (grey). emphasized started shift 1990s PD, 2010s tremendous increase last years, resurgence (B) Position mediating represented; simplified adapted Luscher 2021. structures, node Amg: Amygdala, DS: Dorsal Striatum, NAc: Nucleus Accumbens, LHb: Lateral Habenula, mPFC: medial Prefrontal Cortex, PVT: ParaVentricular Thalamus, SNc: Substantia Nigra Compacta, vHipp: Hippocampus, VP: Ventral Pallidum, Tegmental Area, ZI: Incerta.

Язык: Английский

Процитировано

0
Reward monitoring in the frontopolar cortex of macaques DOI Creative Commons
Lorenzo Ferrucci, Francesco Ceccarelli, Fabrizio Londei

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 12, 2025

Abstract Reward processing involves several prefrontal cortex areas, enabling individuals to learn from behavioral outcomes and shape decisions. However, the role of frontopolar (FPC) in these processes remains unclear due limited single-neuron research. In this study, we recorded neural activity FPC two macaques performing a fast-learning task, object-in-place reward which examined how size affects learning. Results showed that feedback monitoring extends value specific choices. Moreover, once association between scenes had been learned, before choice reflected future animal’s behavior stay or switch on their previous strategy, i.e., choose same target other one. These results suggest neurons integrated information for action later reprocessed it decide best strategy adopt, determining whether maintain change plan.

Язык: Английский

Процитировано

0
GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response DOI
Man Yuan,

Gao Tan,

Danrui Cai

и другие.

Neuroscience Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Язык: Английский

Процитировано

2
The zona incerta system: Involvement in Parkinson's disease DOI

Yaying Shi,

Jing Zhang,

Minxia Xiu

и другие.

Experimental Neurology, Год журнала: 2024, Номер 382, С. 114992 - 114992

Опубликована: Окт. 10, 2024

Язык: Английский

Процитировано

2