International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13086 - 13086
Опубликована: Дек. 5, 2024
Alzheimer's
disease
imposes
an
increasing
burden
on
aging
Western
societies.
The
disorder
most
frequently
appears
in
its
sporadic
form,
which
can
be
caused
by
environmental
and
polygenic
factors
or
monogenic
conditions
of
incomplete
penetrance.
According
to
the
authors,
majority
cases,
represents
aggravated
form
natural
central
nervous
system.
It
characterized
decreased
elimination
amyloid
β
Ageing and Neurodegenerative Diseases,
Год журнала:
2025,
Номер
5(1)
Опубликована: Март 10, 2025
Aim:
Melatonin
has
been
found
to
inhibit
the
induced
Tau
hyperphosphorylation
in
cellular
and
animal
models.
However,
underlying
mechanisms
are
not
fully
understood,
especially
with
respect
ability
of
melatonin
control
Tau-related
pathologies
neuronal
damage.
Methods:
6-month-old
male
P301S
mice
were
employed
evaluate
effects
intranasally
administered
(10
mg/kg)
on
tauopathy
progression
ferroptosis.
HT22
D1A
cells
also
further
uncover
mechanism
iron
metabolism.
Results:
We
verified
that
intranasal
administration
effectively
improved
via
modulating
activity
several
kinases,
accompanied
by
a
stifling
synaptic
loss,
degeneration,
neuroinflammation,
oxidative
damage
transgenic
mice.
Moreover,
restoration
ferroptosis-related
indicators
such
as
accumulation
hippocampal
neurons,
metabolism,
activating
Nrf2/GPX4
signaling
contributed
which
supplementation
ameliorated
behavioral
deficits
Interestingly,
we
treatment
may
stimulate
astrocytes
secrete
hepcidin
vitro,
turn
helps
alleviate
efflux
stressed
conditions.
Conclusion:
These
findings
provide
compelling
evidence
plays
role
improving
tauopathies
ferroptosis
neurodegenerative
disease.
Rejuvenation Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Emerging
evidence
suggests
that
bioactive
peptides
from
various
foods
have
therapeutic
potentials
in
improving
cognitive
function
Alzheimer's
disease
(AD)
and
mild
impairment
(MCI).
We
aimed
to
explore
the
characteristics
of
these
their
mechanisms
on
AD/MCI
using
a
network
pharmacology
approach.
compiled
dataset
cognition-enhancing
literatures
identified
shared
targets
between
Swiss
Target
Predication,
PharmMapper,
OMIM,
GeneCards,
TTD,
Drugbank
databases.
then
performed
functional
enrichment
analysis
constructed
gene–gene
interaction
identify
key
hub
targets.
Additionally,
we
investigated
transcription
factors
(TFs)
microRNAs
(miRNAs)
regulating
genes.
Molecular
docking
dynamic
simulations
were
AutoDock
Vina
GROMACS.
59
oligopeptides,
typically
short
rich
arginine.
These
predicted
interact
with
222
potential
relevant
AD/MCI,
pathways
mainly
involving
neuroactive
ligand-receptor
interactions
inflammation.
15
targets,
regulated
by
144
TFs
95
miRNAs.
Notably,
containing
"Trp-Tyr"
sequence
demonstrated
strong
binding
affinities
many
especially
matrix
metalloproteinase-9.
The
findings
provided
valuable
insights
into
molecular
through
which
may
act
against
highlight
for
future
exploration
natural
foods.
ABSTRACT
In
this
study,
we
report
for
the
first
time
that
de
novo
sequencing
can
be
combined
with
parallel
peptide
synthesis
to
facilitate
high‐throughput
activity
screening
of
biological
peptides
from
natural
food.
Sea
cucumber
(
Stichopus
japonicus
)
intestine
was
utilized
as
an
example,
undergoing
gastrointestinal
digestion
followed
by
predict
potential
sequences.
These
were
efficiently
synthesized
using
a
readily
accessible
filter
pipette
tip
reaction
vessels,
eliminating
use
any
expensive
equipment.
This
method
enabled
numerous
at
milligram
scale
microfluidic
amino
acid
flowing
through
solid
resin.
After
screening,
LSPGV
shown
exhibit
most
potent
antioxidant
(DPPH
radical
scavenging
[DRSA]:
88.96%)
and
strongest
acetylcholinesterase
(AChE)
inhibition
(IC
50
7.32
μM)
simultaneously.
The
reduction
in
paralysis,
amyloid‐β
(Aβ)
aggregation,
AChE
vivo
further
confirmed
animal
model,
Caenorhabditis
elegans
.
3D
structure
simulation
molecular
docking
study
also
conducted
illustrate
its
conformation
favorable
binding
interactions
AChE.
As
candidate
Alzheimer's
disease
(AD)
treatment,
significantly
enhances
value
sea
by‐products.
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(9)
Опубликована: Сен. 19, 2024
Spinal
cord
injury
(SCI)
is
a
severe
central
nervous
system
disorder
with
no
currently
available
effective
treatment.
Microglia
are
immune
cells
in
the
that
play
crucial
roles
SCI
occurrence,
development,
and
recovery
stages.
They
exhibit
dynamic
polarization
over
time
can
switch
between
classical
activation
(M1)
alternative
(M2)
phenotypes
to
respond
environmental
stimuli.
The
M1
phenotype
involved
initiating
sustaining
inflammatory
responses,
while
M2
exerts
anti-inflammatory
effects
promotes
tissue
repair
damaged
areas.
Inhibiting
promoting
have
become
hotspots
regulating
neuroinflammation
treating
SCI.
This
article
provides
comprehensive
review
centered
on
modulating
microglial
for
Biology,
Год журнала:
2024,
Номер
13(11), С. 907 - 907
Опубликована: Ноя. 7, 2024
Neurotrophins
(NTs)
constitute
a
family
of
small
protein
messengers
that
play
fundamental
role
in
both
the
central
and
peripheral
nervous
systems.
In
particular,
nerve
growth
factor
(NGF)
brain-derived
neurotrophic
(BDNF)
subtle
survival,
differentiation,
functioning
neuronal
populations,
as
well
fine
regulation
immune
functions.
The
SARS-CoV-2
infection
was
characterized
by
sequela
symptoms
(serious
respiratory
pathology,
inflammatory
storm,
neurological
discomfort,
up
to
less
serious
flu-like
symptoms),
which
caused,
at
end
2023,
more
than
7
million
deaths
worldwide.
Despite
official
pandemic,
physical
psychological
consequences
are
currently
object
scientific
research,
acute
chronic/long-lasting
(Long-COVID-19).
Given
multifactorial
nature
outcomes
adults
children,
several
studies
have
investigated
potential
involvement
NGF
BDNF
systems
pathology.
This
narrative
review
aims
summarize
most
recent
evidence
on
this
crucial
topic.
Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1104 - 1104
Опубликована: Сен. 2, 2024
A
low
level
of
Neurotrophins
(NTs),
their
Tyrosine
Kinase
Receptors
(Trks),
Vascular
Endothelial
Growth
Factors
(VEGFs)
and
receptors,
mainly
VEGFR1
VEGFR2,
characterizes
AD
brains.
The
use
NTs
VEGFs
as
drugs
presents
different
issues
due
to
permeability
the
blood−brain
barrier,
poor
pharmacokinetic
profile,
relevant
side
effects.
To
overcome
these
issues,
functional
structural
NT
mimics
have
been
employed.
Being
aware
that
N-terminus
domain
key
for
binding
selectivity
activation
Trks
need
avoid
or
delay
proteolysis,
we
herein
report
on
mimicking
ability
two
cyclic
peptide
encompassing
Brain
Derived
Factor
(BDNF),
(c-[HSDPARRGELSV-]),
cBDNF(1-12)
Neurotrophin3
(NT3),
(c-[YAEHKSHRGEYSV-]),
cNT3(1-13).
features
were
characterized
by
a
combined
thermodynamic
spectroscopic
approach
(potentiometry,
NMR,
UV-vis
CD)
was
extended
copper(II)
ion
complexes.
SH-SY5Y
cell
assays
show
Cu2+
present
at
sub-micromolar
in
complete
culture
media
affects
treatments
with
peptides.
cNT3(1-13)
act
ionophores,
induce
neuronal
differentiation
promote
CREB
phosphorylation
copper
dependent
manner.
Consistently,
both
stimulate
BDNF
VEGF
expression
well
release;
VEGFRs.
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 5273 - 5284
Опубликована: Ноя. 1, 2024
This
study
aimed
to
examine
the
correlation
and
prognostic
value
of
serum
irisin
levels
in
acute
ischaemic
stroke
(AIS)
subsequent
development
hemiplegia.
