Arsenic exposure accelerates type 1 diabetes mellitus progression via pyroptosis pathway in mice DOI Creative Commons

L. Lei,

Mengling Chen,

Chuan Qin

и другие.

Chemico-Biological Interactions, Год журнала: 2024, Номер 406, С. 111348 - 111348

Опубликована: Дек. 13, 2024

Язык: Английский

Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases DOI Creative Commons

Yanqiu Ding,

Nanyang Liu,

Dawu Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 17, 2024

Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In 2022, CVDs contributed to 19.8 million deaths globally, accounting for one-third all global deaths. With an aging population and changing lifestyles, pose a major threat human health. Mitochondria-associated endoplasmic reticulum membranes (MAMs) communication platforms between cellular organelles regulate physiological functions, including apoptosis, autophagy, programmed necrosis. Further research has shown that MAMs play critical role in pathogenesis CVDs, myocardial ischemia reperfusion injury, heart failure, pulmonary hypertension, coronary atherosclerosis. This suggests could be important therapeutic target managing CVDs. The goal this study is summarize protein complex MAMs, discuss its pathological mechanisms terms functions such as Ca

Язык: Английский

Процитировано

5
Targeting Pyroptosis: A Novel Strategy of Ginseng for the Treatment of Diabetes and Its Chronic Complications DOI
Ke Li,

Yajun Wang,

Chen Chen

и другие.

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156430 - 156430

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Integrative Bioinformatics Analysis of Pyroptosis-Related Genes and Analysis of Immune Cell Infiltration in Infantile Hemangioma Regression DOI Creative Commons
Lan Liu,

Sheng Lin,

Jianxi Bai

и другие.

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2025, Номер Volume 18, С. 291 - 302

Опубликована: Янв. 1, 2025

Infantile hemangiomas (IHs) are characterized by spontaneous regression, and their pathogenesis involves immune cell infiltration programmed death. The molecular pathways mechanisms involved in pyroptosis IHs still unclear. This study aimed to identify genes related IH regression bioinformatics methods explore the effects of these pyroptosis-related (PRGs) on disease pathology infiltration. microarray dataset GSE127487 was assessed differentially expressed (DEGs) between proliferation-phase (PIHs) involution-phase (IIHs). DEGs that overlapped with PRGs were considered IH-PRGs. IH-PRGs validated subjected functional enrichment analysis Genomes pathway analyses. Gene set (GSEA) also performed analyse biological significance DEGs. NetworkAnalyst database used correlation network miRNAs as well transcription factors. STRING online Cytoscape hub-IH-PRGs. Additionally, a single-sample GSEA algorithm applied assess IHs, hub-IH-PRGs infiltrating cells. Fourteen identified. IL6, EGFR, IRF1 IL32 identified displayed excellent diagnostic performance. Immune revealed notable differences CD8+ T cells, Tgd cells Th17 PIHs IIHs. IL-6 significantly positively correlated negatively infiltration; EGFR Four PRGs, namely, IL32, may play significant role regression. provides insights into underlying pathogenesis, highlighting importance

Язык: Английский

Процитировано

0
Non-coding RNAs modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review DOI

Wenyu Shang,

Xiaofei Geng,

Xitong Sun

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142865 - 142865

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis DOI

Shaocong Wang,

Xinzhe Chen, Kun Wang

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

0
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy DOI
Zhenhao Cai, Fengnan Sun, Qingyan Wang

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114690 - 114690

Опубликована: Апрель 21, 2025

Язык: Английский

Процитировано

0
Functional transformation of macrophage mitochondria in cardiovascular diseases DOI

Jing Wei,

Mingyu Peng,

Hongxiang Lu

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Язык: Английский

Процитировано

2
Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions DOI Creative Commons
Ya Liu,

Danxia Wang,

Xiang Liu

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 5, 2024

Pyroptosis, an inflammatory regulated cell death (RCD) mechanism, is characterized by cellular swelling, membrane rupture, and subsequent discharge of contents, exerting robust proinflammatory effects. Recent studies have significantly advanced our understanding pyroptosis, revealing that it can be triggered through inflammasome- caspase-independent pathways, interacts intricately with other RCD pathways (e.g., necroptosis, ferroptosis, cuproptosis). The pathogenesis pulmonary fibrosis (PF), including idiopathic (IPF) interstitial lung diseases, involves a multifaceted interplay factors such as pathogen infections, environmental pollutants, genetic variations, immune dysfunction. This chronic progressive disease persistent inflammation, extracellular matrix (ECM) accumulation, fibrotic alveolar wall thickening, which potentially contribute to deteriorated function. Despite recent advances in the mechanisms regulates PF are not entirely elucidated, effective strategies improve clinical outcomes remain unclear. review strives deliver comprehensive overview biological functions molecular exploring its roles PF. Furthermore, examines potential biomarkers therapeutic agents for anti-fibrotic treatments.

Язык: Английский

Процитировано

2
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis DOI
Bingqian Zhou,

Qin Qin,

Fang Yue

и другие.

Life Sciences, Год журнала: 2024, Номер 358, С. 123108 - 123108

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

1
Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway DOI Creative Commons

Chenglong Zhou,

Jun Li, Xiaochu Wu

и другие.

Experimental Gerontology, Год журнала: 2024, Номер 198, С. 112626 - 112626

Опубликована: Ноя. 1, 2024

Diabetes mellitus (DM) patients are at increased risk of cognitive impairment. The precise mechanisms underlying the association between DM and impairment remain unclear. Spleen tyrosine kinase (SYK), a crucial regulator signal transduction, has been implicated in microglial pyroptosis experimental ischemic stroke models. present study investigated potential role SYK DM-associated

Язык: Английский

Процитировано

1