Cinnamon for Metabolic Diseases and Their Cardiovascular and Hepatic Complications: A Mechanistic Review DOI

Junpeng Wu,

Wenhan Jia,

Dongyu Min

и другие.

The American Journal of Chinese Medicine, Год журнала: 2024, Номер 52(08), С. 2403 - 2421

Опубликована: Янв. 1, 2024

Cinnamon is one of the world’s oldest and most popular spices, derived from inner bark several tree species genus Cinnamomum. During last two decades, cinnamon has demonstrated beneficial metabolic effects not only in animal experiments but also clinical trials. Even recent meta-analyses have shown protective on different components syndrome their complications. In 5 years, experimental studies unraveled intricate molecular mechanisms underlying antihypertensive, antihyperglycemic, lipid-lowering, weight-lowering, cardioprotective properties cinnamon. This review paper will discuss how its active components, particularly cinnamaldehyde, suppress inflammation oxidative stress, modulate mitochondrial dysfunction, regulate glucose uptake, insulin resistance, lipogenesis, beta-oxidation, Ca2+ signaling, other cellar events at level. Specifically, we delve into involved to provide a deeper insight can bring such effects. hopes encourage use settings, guide combination with drugs used treat based mechanism action, support concept complementary medicine for diseases.

Язык: Английский

Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

3
Review on the Role of Polyphenols in Preventing and Treating Type 2 Diabetes: Evidence from In Vitro and In Vivo Studies DOI Open Access
Fereidoon Shahidi, Renan Danielski

Nutrients, Год журнала: 2024, Номер 16(18), С. 3159 - 3159

Опубликована: Сен. 19, 2024

Type 2 diabetes (T2D) is one of the leading causes death globally. There was a 70% increase in diabetes-related deaths between 2000 and 2020, particularly among males. This non-communicable disease characterized by increased insulin resistance, to elevated blood sugar levels and, if untreated, resulting complications such as nerve damage, kidney disease, blindness, poor wound healing. T2D management includes dietary intervention, physical exercise, administration sugar-lowering medication. However, these medications often have side effects related intestinal discomfort. Therefore, natural alternatives standard are being sought improve quality life for individuals with this condition. Polyphenols, which naturally occurring plant metabolites, emerged strong candidates control. Various phenolic acids (e.g., chlorogenic acid), flavonoids quercetin), proanthocyanidins procyanidin B2), gallotannins monogalloyl hexoside), ellagitannins ellagic acid hexoside) can enhance sensitivity tissues, reduce chronic inflammation, scavenge free radicals, secretion, inhibit enzymes involved carbohydrate digestion, regulate glucose transport across cell membranes, modulate gut microbiota. contribution compiles up-to-date evidence from vitro vivo studies on role polyphenols prevention T2D, emphasizing mechanisms action underlying effects.

Язык: Английский

Процитировано

8
HPB@LA@PDA nanoplatform ameliorates osteoarthritis by scavenging reactive oxygen species and remodelling the inflammatory microenvironment: An in vitro and in vivo study DOI

Dongze Ren,

Mingjie Liu,

Min Cao

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160592 - 160592

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health DOI

Ahmet Alperen Palabiyik,

Esra Palabıyık

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

1
Understanding chronic inflammation: couplings between cytokines, ROS, NO, Cai2+, HIF-1α, Nrf2 and autophagy DOI Creative Commons
Katarzyna Michalak,

Alicja Michalak

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 8, 2025

Chronic inflammation is an important component of many diseases, including autoimmune intracellular infections, dysbiosis and degenerative diseases. An element this state the mainly positive feedback between inflammatory cytokines, reactive oxygen species (ROS), nitric oxide (NO), increased calcium, hypoxia-inducible factor 1-alpha (HIF-1α) stabilisation mitochondrial oxidative stress, which, under normal conditions, enhance response against pathogens. Autophagy nuclear erythroid 2-related 2 (Nrf2)-mediated antioxidant are negatively coupled with above-mentioned elements to maintain defence at a level appropriate severity infection. The current review first attempt build multidimensional model cellular self-regulation chronic inflammation. It describes feedbacks involved in explains possible pathways by which becomes chronic. multiplicity suggests that symptomatic treatment should focus on inhibiting multiple effectively suppress all dysregulated inflammation, calcium mito-stress other metabolic disturbances.

Язык: Английский

Процитировано

1
The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions DOI Creative Commons
Xinyu Lin, Wenkai Liu, Xizhuo Hu

и другие.

Pharmacological Research, Год журнала: 2024, Номер 207, С. 107324 - 107324

Опубликована: Июль 24, 2024

This review rigorously assesses the burgeoning research into role of polyphenols in modulating mitophagy, an essential cellular mechanism for targeted removal impaired mitochondria. These natural compounds, known their low toxicity, are underscored potential therapeutic strategies against a diverse array diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply molecular mechanisms whereby promote particularly by influencing crucial signaling pathways transcriptional regulators, including phosphatase tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include neuroprotective properties resveratrol curcumin, which affect both autophagic mitochondrial dynamics, pioneering integration with other substances to amplify effectiveness. Furthermore, confronts issue polyphenol bioavailability emphasizes imperative clinical trials corroborate viability. By delivering exhaustive synthesis contemporary insights recent advancements mitophagy research, this endeavors catalyze additional foster creation innovative modalities that exploit distinctive attributes manage prevent disease.

Язык: Английский

Процитировано

5
Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson’s disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy DOI
Wessam H. Elesawy, Ayman E. El-Sahar,

Rabab H. Sayed

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 138, С. 112640 - 112640

Опубликована: Июль 8, 2024

Язык: Английский

Процитировано

4
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis DOI Creative Commons
Yi Chen,

Hefang Xiao,

Zirui Liu

и другие.

Biomolecules, Год журнала: 2024, Номер 14(8), С. 970 - 970

Опубликована: Авг. 8, 2024

Osteoporosis (OP) is a common metabolic bone disease characterized by low mass, decreased mineral density, and degradation of tissue microarchitecture. However, our understanding the mechanisms remodeling factors affecting mass remains incomplete. Sirtuin1 (SIRT1) nicotinamide adenine dinucleotide-dependent deacetylase that regulates variety cellular metabolisms, including inflammation, tumorigenesis, metabolism. Recent studies have emphasized important role SIRT1 in homeostasis. This article reviews metabolism OP also discusses therapeutic strategies future research directions for targeting SIRT1.

Язык: Английский

Процитировано

4
Propofol Inhibits Oxidative Stress-Induced Neuronal Cell Ferroptosis and Promotes Synaptic Plasticity via the AMPK/ SIRT1/PGC-1α Axis DOI Creative Commons

Rongmin Chen,

Miao Zhang, Le Lv

и другие.

Indian Journal of Pharmaceutical Education and Research, Год журнала: 2025, Номер 59(1), С. 185 - 195

Опубликована: Янв. 6, 2025

Aim/Background Propofol, recognized for its quick and effective action as a hypnotic anesthetic, is frequently utilized in clinical practice. Our research intended to investigate the mechanism by which propofol inhibits neuronal ferroptosis promotes synaptic plasticity via mitochondrial energy regulation. Materials Methods Mouse Hippocampal Neurons (HT22) cells were treated with RAS-Selective Lethal 3 (RSL3) followed Reactive Oxygen species (ROS) detection. Expression levels of regulation analyzed. HT22 Sirtuin 1 (SIRT1) inhibitor before treatment. Level ROS, Fe2+ genes expression measured. Results In RSL3-Low+propofol cohort, exhibiting stark contrast both mock group RSL3-High+propofol group, administration notably attenuated Cyclooxygenase 2 (COX-2) Long-chain-fatty-acid-CoA Ligase 4 (ACSL4), while concurrently enhancing Glutathione Peroxidase (GPX4), Solute Carrier Family 7 Member 11 (SLC7A11), Nuclear Factor-like (NRF2), Ferritin Heavy chain (FTH1), Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase (AMPK), SIRT1 PPARγ Coactivator-1 α (PGC-1α). ROS substantially greater Selisistat+propofol than whereas PGC-1α considerably less comparison groups. Conversely, showed significantly higher AMPK, SIRT1, PGC-1α, Synapsin-1 (SYN1) PSD-95 compared (p <0.05). Conclusion Propofol oxidative stress-induced cell AMPK/ SIRT1/PGC-1α axis.

Язык: Английский

Процитировано

0
Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review DOI Creative Commons
Ana Isabel Beltrán-Velasco

Metabolites, Год журнала: 2025, Номер 15(2), С. 128 - 128

Опубликована: Фев. 13, 2025

Background: Brain glycogen is imperative for neuronal health, as it supports energy demands and metabolic processes. This review examines the pathways involved in storage utilization central nervous system, emphasizing their role both physiology pathology. It explores how alterations metabolism contribute to neurological disorders, including neurodegenerative diseases, epilepsy, conditions while highlighting bidirectional interaction between neurons glia maintaining brain homeostasis. Methods: A comprehensive search of articles published 2015 2025 was conducted using following databases: ScienceDirect, Scopus, Wiley, Web Science, Medline, PubMed. The selection relevant studies based on focus its conditions, with that did not meet inclusion criteria being excluded. Results: processes are subject rigorous regulation by astrocyte-neuron interactions, thereby ensuring homeostasis availability. dysregulation mobilization has been implicated development synaptic dysfunction, excitotoxicity, neurodegeneration a variety disorders. For instance, aberrant accumulation diseases such Lafora disease associated severe neurodegeneration, impaired shown exacerbate deficits Alzheimer's epilepsy. Conclusions: Targeting represents promising approach therapeutic intervention However, translation these strategies human models remains challenging, particularly regard long-term safety specificity glycogen-targeted therapies.

Язык: Английский

Процитировано

0