Advances of the MAPK pathway in the treatment of spinal cord injury
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(6)
Опубликована: Июнь 1, 2024
Spinal
cord
injury
(SCI)
represents
a
complex
pathology
within
the
central
nervous
system
(CNS),
leading
to
severe
sensory
and
motor
impairments.
It
activates
various
signaling
pathways,
notably
mitogen-activated
protein
kinase
(MAPK)
pathway.
Present
treatment
approaches
primarily
focus
on
symptomatic
relief,
lacking
efficacy
in
addressing
underlying
pathophysiological
mechanisms.
Emerging
research
underscores
significance
of
MAPK
pathway
neuronal
differentiation,
growth,
survival,
axonal
regeneration,
inflammatory
responses
post-SCI.
Modulating
this
post-injury
has
shown
promise
attenuating
inflammation,
minimizing
apoptosis,
alleviating
neuropathic
pain,
fostering
neural
regeneration.
Given
its
pivotal
role,
emerges
as
potential
therapeutic
target
SCI
management.
This
review
synthesizes
current
knowledge
pathology,
delineates
pathway's
characteristics,
explores
dual
roles
interventions.
Furthermore,
it
addresses
existing
challenges
context
SCI,
proposing
solutions
overcome
these
hurdles.
Our
aim
is
offer
comprehensive
reference
for
future
laying
groundwork
targeted
strategies.
Язык: Английский
A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions
Diagnostics,
Год журнала:
2024,
Номер
14(11), С. 1168 - 1168
Опубликована: Май 31, 2024
Long
COVID,
characterized
by
a
persistent
symptom
spectrum
following
SARS-CoV-2
infection,
poses
significant
health,
social,
and
economic
challenges.
This
review
aims
to
consolidate
knowledge
on
its
epidemiology,
clinical
features,
underlying
mechanisms
guide
global
responses;
Язык: Английский
Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Journal of Neuroimmune Pharmacology,
Год журнала:
2025,
Номер
20(1)
Опубликована: Фев. 12, 2025
Язык: Английский
Neurodegenerative diseases and neuroinflammation-induced apoptosis
Open Life Sciences,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Abstract
Neuroinflammation
represents
a
critical
pathway
in
the
brain
for
clearance
of
foreign
bodies
and
maintenance
homeostasis.
When
neuroinflammatory
process
is
dysregulate,
such
as
over-activation
microglia,
which
results
excessive
accumulation
free
oxygen
inflammatory
factors
brain,
among
other
factors,
it
can
lead
to
an
imbalance
homeostasis
development
various
diseases.
Recent
research
has
indicated
that
numerous
neurodegenerative
diseases
closely
associated
with
neuroinflammation.
The
pathogenesis
neuroinflammation
intricate,
involving
alterations
genes
proteins,
well
activation
inhibition
signaling
pathways.
Furthermore,
inflammation
result
neuronal
cell
apoptosis,
further
exacerbate
extent
disease.
This
article
presents
summary
recent
studies
on
relationship
between
apoptosis
caused
by
aim
identify
link
two
provide
new
ideas
targets
exploring
pathogenesis,
prevention
treatment
Язык: Английский
OLFACTORY DYSFUNCTION: AN EARLY INDICATOR OF PARKINSON'S DISEASE
Brain Disorders,
Год журнала:
2025,
Номер
unknown, С. 100209 - 100209
Опубликована: Март 1, 2025
Язык: Английский
Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease
Inflammation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
There
is
increasing
interest
in
developing
therapeutic
interventions
aimed
at
preventing
neuroinflammation
Parkinson's
disease
(PD).
However,
the
specific
characteristics
of
inflammation
across
different
cell
types
and
underlying
mechanisms
PD-related
remain
inadequately
understood.
In
this
study,
we
conducted
an
analysis
single-cell
RNA
sequencing
(scRNA-seq)
microarray
data
derived
from
human
PD
midbrain
tissue,
specifically
focusing
on
substantia
nigra
compacta
(SNc).
These
datasets
were
sourced
(GEO)
database.
We
utilized
GSVA,
GSEA,
as
well
KEGG
GO
analyses
to
explore
transcriptional
variations
associated
with
PD.
Furthermore,
trajectory
SCENIC
uncover
progression.
Subsequent
animal
cellular
experiments
validated
role
regulon
regulating
neuroinflammation.
Results:
Our
revealed
that
microglia
displayed
highest
levels
inflammatory
activity,
characterized
by
increased
abundance
proinflammatory
activated
state
within
SNc
patients.
This
finding
was
further
a
mouse
model
induced
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP).
The
transcription
factor
STAT3
demonstrated
significant
upregulation
implicated
promoting
response
activating
context.
1-methyl-4-phenylpyridine
(MPP
+)-induced
BV2
model,
inhibition
led
reduced
inflammation,
hindered
phosphorylation,
decreased
production
factors.
downregulation
P-STAT3
alleviated
harmful
effects
SH-SY5Y
cells
cocultured
conditioned
medium.
Conclusions:
study
underscored
pivotal
central
regulator
activation
findings
offer
fresh
insights
into
pathogenesis
suggest
potential
avenues
for
development
novel
strategies.
Язык: Английский
IL‐6 and Olfactory Dysfunction: Focus on Changes, Effects, and Mechanisms
Mediators of Inflammation,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
The
sense
of
smell
is
vital
for
human
life
and
risk
identification.
Many
diseases
can
cause
olfactory
disorders,
early
identification
intervention
disorders
are
crucial.
Currently,
the
diagnosis
in
clinical
practice
mostly
relies
on
subjective
visual
analog
scale
(VAS)
evaluations,
expensive
complex
imaging,
neurophysiological
examinations,
which
lead
to
poor
patient
compliance
low
completion
rates.
Therefore,
there
an
urgent
need
identify
novel,
objective,
easily
detectable
biological
indicators.
Interleukin‐6
(IL‐6)
inflammatory
factor
that
closely
associated
with
dysfunction
various
diseases.
However,
role
IL‐6
occurrence
development
not
yet
clear,
limits
its
application.
This
article
reviews
changes
possible
mechanisms
aim
providing
a
reference
application
as
biomarker
promoting
in‐depth
exploration
mechanism
disorders.
Язык: Английский
A Comprehensive Global Review of Epidemiology, Clinical Management, Socio-Economic Impacts and National Responses of Long COVID with Future Research Directions
Опубликована: Апрель 26, 2024
Background:
Long
COVID,
characterized
by
a
persistent
symptom
spectrum
following
SARS-CoV-2
infection,
poses
significant
health,
social,
and
economic
challenges.
This
review
aims
to
consolidate
knowledge
on
its
epidemiology,
clinical
features,
underlying
mechanisms
guide
global
responses;
Methods:
We
conducted
systematic
literature
review,
analyzing
peer-reviewed
articles
reports
gather
comprehensive
data
long
COVID’s
symptomatology,
management
approaches;
Results:
Our
analysis
revealed
wide
array
of
COVID
symptoms
risk
factors,
with
notable
demographic
variability.
The
current
understanding
pathophysiology
suggests
multifactorial
origin
yet
remains
partially
understood.
Emerging
diagnostic
criteria
potential
therapeutic
strategies
were
identified,
highlighting
advancements
in
management.;
Conclusion:
highlights
the
multifaceted
nature
revealing
broad
symptoms,
diverse
complex
interplay
physiological
underpinning
condition.
disorders
will
continue
weigh
healthcare
systems
years
come.
Ad-dressing
requires
holistic
strategy
that
integrates
care,
social
support,
policy
initiatives.
findings
underscore
need
for
increased
international
cooperation
research
health
planning
address
challenges
COVID.
There
is
call
continued
refinement
treatment
modalities,
emphasizing
multidisciplinary
approach
manage
ongoing
evolving
impacts
Язык: Английский
SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12079 - 12079
Опубликована: Ноя. 10, 2024
Alpha-synuclein
(α-syn)
is
a
140-amino-acid,
intrinsically
disordered,
soluble
protein
that
abundantly
present
in
the
brain.
It
plays
crucial
role
maintaining
cellular
structures
and
organelle
functions,
particularly
supporting
synaptic
plasticity
regulating
neurotransmitter
turnover.
However,
for
reasons
not
yet
fully
understood,
α-syn
can
lose
its
physiological
begin
to
aggregate.
This
altered
disrupts
dopaminergic
transmission
causes
both
presynaptic
postsynaptic
dysfunction,
ultimately
leading
cell
death.
A
group
of
neurodegenerative
diseases
known
as
α-synucleinopathies
characterized
by
intracellular
accumulation
deposits
specific
neuronal
glial
cells
within
certain
brain
regions.
In
addition
Parkinson's
disease
(PD),
these
conditions
include
dementia
with
Lewy
bodies
(DLBs),
multiple
system
atrophy
(MSA),
pure
autonomic
failure
(PAF),
REM
sleep
behavior
disorder
(RBD).
Given
disorders
are
associated
α-syn-related
neuroinflammation-and
considering
SARS-CoV-2
infection
has
been
shown
affect
nervous
system,
COVID-19
patients
experiencing
neurological
symptoms-it
proposed
may
contribute
neurodegeneration
PD
other
promoting
misfolding
aggregation.
this
review,
we
focus
on
whether
could
act
an
environmental
trigger
facilitates
onset
or
progression
α-synucleinopathies.
Specifically,
new
evidence
potential
modulating
function
discuss
causal
relationship
between
development
parkinsonism-like
symptoms.
Язык: Английский